Abstract
�²3-adrenergic receptor polymorphism is related to cardiometabolic risk factors in obese Brazilian subjects
Author(s): V.A. Genelhu, E.A. Francischetti, S.F.P. Duarte, B.M.J. Celoria, R.C. Oliveira, P.H. Cabello and M.M.G. PimentelWe determined whether ADRβ3 polymorphism is associated with obesity-related traits in 140 obese patients. Molecular analysis was performed by PCR and RFLP. Individuals carrying the Arg64 allele had a lower waist-to-hip ratio, higher adiponectin and high-density lipoprotein cholesterol levels, and a tendency towards lower blood pressure. In contrast, Trp64/Trp64 carriers were at greater risk for dysmetabolic phenotypes (odds ratio = 2.88, P = 0.03).
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