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Association between the -77T>C polymorphism in the DNA repair gene XRCC1 and lung cancer risk

Author(s): B.B. Sun, J.Z. Wu, Y.G. Li and L.J. Ma

Numerous studies have evaluated the association between the X-ray repair cross-complementing group 1 (XRCC1) DNA repair gene polymorphism -77T>C and lung cancer risk. However, this association is controversial. We used PubMed and Embase to identify 5 case-control studies, which included 2488 lung cancer cases and 2576 controls, for inclusion in a comprehensive meta-analysis in order to assess this association.