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Association between TNF-�± -308G>A and -238G>A gene polymorphisms and TNF-�± serum levels in Mexican colorectal cancer patients

Author(s): I.A. Guti�©rrez-Hurtado, A.M. Puebla-P�©rez, J.I. Delgado-Saucedo, L.E. Figuera, G.M. Z�º�±iga-Gonz�¡lez, K. Gomez-Mariscal,C.A. Ronquillo-Carre�³n and M.P. Gallegos-Arreola

The objective of this study was to examine the association between TNF-α serum levels and -308G>A and -238G>A polymorphisms in the corresponding gene by comparing healthy subjects to colorectal cancer (CRC) patients from a Mexican population. Serum levels of TNF-α were found to significantly differ between CRC patients and controls (P = 0.001), but no relationship between the -308G>A and -238G>A polymorphisms and increased CRC risk was established (P > 0.05). However, an association between the -308G>A variant and disease became evident when the distribution of AA-GA genotypes was examined in patients with hematologic toxicity (neutropenia) and those without (odds ratio = 3.356, 95% confidence interval = 1.295- 8.698, P = 0.013). The GG haplotype was more common in controls than CRC patients, with a frequency of 0.85 among the former, but this difference was not significant (P > 0.05). In conclusion, TNF-α serum levels and AA-AG genotypes of the TNF-α-308G>A polymorphism may significantly contribute to CRC susceptibility in the population examined in this investigation.