Abstract
Association of paraoxonase polymorphisms with carotid artery atherosclerosis in essential hypertension patients
Author(s): L. Han1,2, X.J. Xu1,2, X.H. Liang1,2 and J. Ma1,2We investigated the relationships between paraoxonase genetic polymorphisms and essential hypertension in carotid artery atherosclerotic patients. The study included 353 Han participants and 240 Uighur participants from Xinjiang; they were further divided into two groups: essential hypertension with carotid artery atherosclerosis (CAAD group) and essential hypertension without carotid artery atherosclerosis (control group). Genotypes were detected by PCR, followed by restriction analyses with specific endonucleases. In Han people, the M allele frequency was significantly higher in the CAAD group than in the control group.
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