Abstract
Cytotoxicity of 1-dodecyl-3-methylimidazolium bromide on HepG2 cells
Author(s): T.H. Li, C.Q. Jing, K.L. Gao, W.Y. Yue and S.F. LiWe evaluated the cytotoxicity of 1-dodecyl-3-methylimidazolium bromide ([C12mim][Br]) on HepG2 cells and its influence on plasma membrane permeability. The results showed that [C12mim][Br] inhibited HepG2 cell growth and decreased cell viability in a concentration-dependent manner. The results also revealed that [C12mim][Br] exposure induced apoptosis in [C12mim][Br]-treated HepG2 cells. In addition, the results showed that [C12mim][Br] increased membrane permeability in HepG2 cells. These results suggest that plasma membrane permeability may be responsible for apoptosis induced by [C12mim][Br] in HepG2 cells.
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