Abstract

Effects of ACE polymorphisms and other risk factors on the severity of coronary artery disease

Author(s): A.I. Guney, D. Ergec, D. Kirac, H. Ozturhan, M. Caner, G. Koc, C. Kaspar, K. Ulucan and M. Agirbasli

Coronary artery disease (CAD) is a multifactorial disease influenced by genetic and environmental factors. Major risk factors of CAD are hypertension, hyperlipidemia, smoking, family history and obesity. Also polymorphisms in the angiotensin-I converting enzyme (ACE) gene can associate with CAD. The relationship between ACE polymorphisms and other risk factors is not well understood in CAD, likely due to the complex interrelation of genetic and environmental risk factors. The aim of this study was to investigate the associations of CAD risk factors and ACE polymorphisms in patients with CAD.

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