Abstract

Generation of bovine (Bos indicus) and buffalo (Bubalus bubalis) adipose tissue derived stem cells: isolation, characterization, and multipotentiality

Author(s): R.V. Sampaio, M.R. Chiaratti, D.C.N. Santos, F.F. Bressan, J.R. Sangalli, A.L.A. S�¡, T.V.G. Silva, N.N. Costa, M.S. Cordeiro, S.S.D. Santos, C.E. Ambrosio, P.R. Adona, F.V. Meirelles, M.S. Miranda and O.M. Ohashi

Previous studies have indicated that the protein tyrosine phosphatase nonreceptor type 22 gene (PTPN22) is associated with type 1 diabetes (T1DM) in the Caucasian population. In the present study, we investigated the relationship between PTPN22 genetic polymorphisms and T1DM in Chinese children. A total of 202 children and adolescents with T1DM and 240 healthy control subjects of Chinese Han origin were included in our analysis. Polymerase chain reaction-restriction fragment length polymorphism was used to determine the presence of the C1858T polymorphism in the PTPN22 gene. We found that the TT +TC genotype and the T allele of C1858T were more frequent in T1DM patients (19.40 and 10.0%, respectively) than in healthy subjects (7.51 and 4.0%, respectively), and the difference was significant (both P PTPN22 gene may increase the risk of T1DM in Chinese children and adolescents.

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