Abstract

Inactivation of Rab23 inhibits the invasion and motility of pancreatic duct adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is charac­terized by a poor prognosis and high mortality rate. In this study, we investigated the expression of Rab23 in non-tumor pancreatic tissues and PDACs via immunohistochemistry. Rab23 was found in 39 of 58 (67.2%) and in 11 of 30 (36.7%) of the PDAC and non-tumor pan­creatic tissue samples (P = 0.0073), respectively. There were signifi­cant correlations between Rab23 expression and unfavorable variables, including cancer differentiation level (P = 0.0089), lymph nodal (P = 0.0099), and distant metastases (P = 0.0173). Inactivation with small interfering RNA against Rab23 in the human pancreatic cancer cell line Panc-1 inhibited the migration and invasive potential of the cells. Our data provide new insight into the essential role of Rab23 in PDAC inva­sion and metastasis and suggest that Rab23 expression is a useful indi­cator of metastatic potential; hence, it may be a new therapeutic target for this common malignancy.

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