Abstract

Study of polymorphic variants of the serotonin 2A receptor gene (5-HT2A) and its possible effects on smoking habits of a population from northeastern Brazil

Author(s): E.S. Ramos Neto1,2, J.O. M�¡gulas1,2, J.J.S. Sousa 1, A.C.M. Moura1, G.R. Pinto1,2, F.K.N. Yoshioka1,2, R. Canalle1,2 and F.J.N. Motta1,2

Previous studies have revealed a genetic component, including genetic polymorphisms in the serotonergic pathway, particularly in the serotonin receptor gene (5-HT2A). The aim of this study was to investigate associations of the T102C (rs6313) and A-1438G (rs6311) polymorphisms with tobacco use in a population from northeastern Brazil. We evaluated these polymorphisms in 135 nonsmokers and 135 smokers using polymerase chain reaction-restricted fragment length polymorphism. The distribution of allele and genotype frequencies and associations of polymorphisms with smoking were assessed with the chi-squared (χ2) test, the Fisher exact test, and odds ratio (OR) with a 95% confidence interval (CI).

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