Abstract
Vasoactive intestinal polypeptide suppresses proliferation of human cord blood-derived hematopoietic progenitor cells by increasing TNF-�± and TGF-�² production in the liver
Author(s): L. Wang1, Q. Xiao1, C.H. Wang3, X. Li3, S.Q. Luo2 and C.W. Tang3The physiology of hepatic hematopoiesis is largely unknown, although studies have indicated that vasoactive intestinal polypeptide (VIP) is involved in this disease. To validate this hypothesis, we assessed the effects of VIP on human cord blood CD34+ cells. We also measured VIP levels and the capacity of vasoactive intestinal polypeptide receptor (VIPR) to bind to VIP in the rat liver during different developmental phases. VIP inhibited the proliferation of cord blood-derived CD34+ cells from concentrations of 10-7-10-12 M. The highest suppression was achieved with 10-8 M VIP at day 10.
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