A. Badawy
Interleukin-27ΓΆΒ?Β?924A/G gene polymorphism is associated with Rheumatoid Arthritis in Egyptian population
Rheumatoid arthritis (RA) is an autoimmune disease with increasing activity of T lymphocytes and abnormal production of inflammatory cytokines. Interleukin-27 (IL-27), a multifunction cytokine with contradictory inflammatory effect. Polymorphism of IL-27 was reported to be predisposed to many inflammatory diseases and autoimmune diseases. We aimed to assess the role.. Read More»
Genet. Mol. Res. 17(2): gmr16039915
DOI: 10.4238/gmr16039915
Matrix metalloproteinase-9 gene polymorphism in hepatocellular carcinoma patients with hepatitis B and C viruses
Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide. In Egypt, the incidence of HCC has doubled over the last decade. Matrix metalloproteinase-9 (MMP-9) plays a key role in cancer invasion and metastasis by degrading the extracellular matrix and basement membrane barriers. A cytosine (C)/thymidine (T) single nucleotide polymorphism at positi.. Read More»
Genet. Mol. Res. 13(3): 2014.September.29.15
DOI: 10.4238/2014.September.29.15
Relationship between NRAMP1 gene polymorphism and efficacy of BCG vaccine in a helminth-infected population
Infection of mothers with schistosomiasis and filariasis has been shown to influence infant responses to neonatal Bacille Calmette-Guérin (BCG) immunization. The genetic makeup of infants is also considered an important determinant for the activity of BCG vaccine. The effect of natural resistance-associated macrophage protein 1 (NRAMP1) gene polymorphism on the efficacy of BCG vaccine wa.. Read More»
Genet. Mol. Res. 12(3): 2013.January.30.4
DOI: 10.4238/2013.January.30.4
Correlation of SPECT imaging, biochemical parameters and mutation with systolic dysfunction
We investigated systolic dysfunction by the use of biochemical laboratory tests and perfusion single-photon emission computed tomography imaging in 32 Pakistani subjects exhibiting symptoms of this disorder. To investigate underlying genetic causes, such as familial hypercholesterolemia, DNA samples from these subjects were screened by PCR-SSCP and DNA sequencing to.. Read More»
Genet. Mol. Res. 12(4): 2013.November.26.6
DOI: 10.4238/2013.November.26.6
Factor V Leiden G1691A and Prothrombin G20210A mutations are associated with repeated spontaneous miscarriage in Northern area of Saudi Arabia
Maternally inherited thrombophilia could be one of the causes of recurrent spontaneous miscarriage (RSM). We aimed to investigate the frequency of three thrombotic gene variants; factor V Leiden (FVL; G1691A), prothrombin (PTH; G20210A), and methylenetetrahydrofolate reductase (MTHFR; C677T) in Saudi patients diagnosed with RSM. A case control study was conducted on.. Read More»
Genet. Mol. Res. 16(4): gmr16039810
DOI: 10.4238/gmr16039810
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