D. Wang
Polymorphisms of AluI and Hin1I loci of the IGF-1R gene and their genetic effects on growth traits in Bian chickens
Growth traits are important economic traits in broiler chicken production. AluI and Hin1I loci are two restriction sites, which are respectively located in exons 2 and 3 of the IGF-1R gene. These two loci are significantly related to the growth traits in Jinghai Yellow chickens. In this study, a correlation analysis was performed between these two loci and the growt.. Read More»
Genet. Mol. Res. 16(2): gmr16029619
DOI: 10.4238/gmr16029619
Alpaca fiber growth is mediated by microRNA let-7b via down-regulation of target gene FGF5
MicroRNAs are very small endogenous RNA molecules that play a crucial role in an array of biological processes, including regulation of skin morphogenesis. The microRNA let-7b is thought to modulate animal hair growth, by binding target genes that encode growth factors. Fibroblast growth factor 5 (FGF5) has been previously reported to be involved in the initiation of the catagen phase of hair g.. Read More»
Genet. Mol. Res. 14(4): 2015.October.28.38
DOI: 10.4238/2015.October.28.38
Transcriptional regulation of CD4 gene expression in porcine kidney epithelial cells by virus-like double-stranded RNA and DNA methyltransferase inhibitor
The effects of virus-like double-stranded RNA (dsRNA, PolyI:C) and DNA methyltransferase inhibitor (Aza-CdR) on CD4 gene expression were investigated in a porcine kidney cell line (PK15). We found that expression levels of TLR3 and IFNα were significantly upregulated by PolyI:C, compared to the untreated PK15 cells, which shows that PolyI:C successfully mimics.. Read More»
Genet. Mol. Res. 13(2): http://dx.doi.org/2014.April.29.13
DOI: http://dx.doi.org/10.4238/2014.April.29.13
Aberrant promoter methylation of the CD4 gene in peripheral blood cells of mastitic dairy cows
Bovine mastitis is the most common and costly disease of dairy cattle. Cluster of differentiation 4 (CD4) is closely related to the immune response in mastitis. We quantified promoter CpG methylation levels of the CD4 gene in Chinese Holsteins with clinical mastitis (CM) and in healthy controls; these levels were quantitatively detected with bisulfite pyrosequencing assays and confirmed by clon.. Read More»
Genet. Mol. Res. 12(4): 2013.December.4.10
DOI: 10.4238/2013.December.4.10
Anti-nociceptive effects of Paecilomyces hepiali via multiple pathways in mouse models
Paecilomyces hepiali (PH), a well-known medicinal fungus, has various pharmacological efficacies. In our study, the antinociceptive effects of PH and underlying mechanisms were evaluated using various mouse models. An acetic acid-induced writhing test, hot plate test, and formalin test were employed to evaluate the antinociceptive activities of PH. The levels of neuronal nitric oxide synthase (.. Read More»
Genet. Mol. Res. 15(3): gmr.15038996
DOI: 10.4238/gmr.15038996
G�?±q gene promoter polymorphisms and rheumatoid arthritis in the Han Chinese population are not associated
Mice that lose Gαq from their immune system can spontaneously develop inflammatory arthritis. Gαq expression in the peripheral blood lymphocytes of rheumatoid arthritis (RA) patients is significantly decreased in comparison to that in healthy individuals, and reduced Gαq expression is closely correlated with RA disease activity. These indicate that Gαq plays critical rol.. Read More»
Genet. Mol. Res. 12(2): 2013.January.4.6
DOI: 10.4238/2013.January.4.6
Whole-genome duplications contributed to the expansion of cytochrome b5 genes in Paramecium tetraurelia
Cytochrome b5 (cyt b5) genes encode ubiquitous electron transport hemoproteins found in animals, plants, fungi, and purple bacteria. However, little is known about their evolutionary history in genomes so far. Here, we conducted an extensive genome-wide survey of cyt b5 genes in 20 representative model species and identified 310 of these genes. Both the absolute number and relative proportion o.. Read More»
Genet. Mol. Res. 12(2): 2013.January.9.1
DOI: 10.4238/2013.January.9.1
Pivotal role of microRNA-9 in osteosarcoma tumorigenesis and tumor progression
MicroRNA-9 (miR-9) has a well-established role in various tumors; the clinical significance and potential mechanism of miR-9 in human osteosarcoma (OS) has not been elucidated. The aim of this study was to investigate the mechanism and role of miR-9 expression in osteosarcoma cells. miR-9 expression in the OS cell line MG-63 and OS tissues was compared to that in a human osteoblastic cell line .. Read More»
Genet. Mol. Res. 15(1): gmr.15017318
DOI: 10.4238/gmr.15017318
Proton pump inhibitor use and risk of spontaneous bacterial peritonitis in cirrhotic patients: a systematic review and meta-analysis
We used a meta-analysis approach to investigate the association between proton pump inhibitor (PPI) use and risk of spontaneous bacterial peritonitis (SBP) in cirrhotic patients. We searched Ovid Medline, Embase, and the Cochrane Library to identify eligible studies. We included studies that compared cirrhotic patients who did or did not use PPIs. The primary outcome was SBP, and the secondary .. Read More»
Genet. Mol. Res. 14(3): 2015.July.3.25
DOI: 10.4238/2015.July.3.25
Novel single nucleotide polymorphisms in the 5' regulatory region of the duck SCD1 gene and their associations with serum biochemical levels and fatty acid composition
Stearoyl-coenzyme A desaturase 1 (SCD1) is the key limiting enzyme in the synthesis of monounsaturated fatty acids, and plays a crucial role in the regulation of oleic acid. In this study, 165 ten-week-old Cherry Valley ducks were used to investigate single nucleotide polymorphisms (SNPs) in the 5' regulatory region of the SCD1 gene, and their associations with duck.. Read More»
Genet. Mol. Res. 15(3): gmr.15039007
DOI: 10.4238/gmr.15039007
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