D. Zhao
Effect of 1,25(OH)2D3 on the proliferation of human mesangial cells and their expression of Ki67
Previous studies have found that 1,25-dihydroxyvitamin D3 [1,25(OH)2D3 or VD3] exerts many biological effects, including the inhibition of cell proliferation and induction of apoptosis, but its mechanism of action remains unclear. The goal of our investigation was to explore the effects of 1,25(OH)2D3 on the proliferation of cultured human mesangial cells and their .. Read More»
Genet. Mol. Res. 16(2): gmr16029191
DOI: 10.4238/gmr16029191
Genetic polymorphisms of the FATP1 gene and their associations with meat quality traits in Chinese Qinchuan cattle
Fatty acid transport protein 1 (FATP1), an integral membrane protein that facilitates long-chain fatty acid influx, is involved in the genetic network for oleic acid synthesis. The aim of this study was to examine the association of FATP1 polymorphisms with live animal meat quality traits in Chinese Qinchuan cattle. Quantitative real-time PCR analysis demonstrated that FATP1 has a broad tissue .. Read More»
Genet. Mol. Res. 14(4): 2015.December.21.14
DOI: 10.4238/2015.December.21.14
Mating system patterns of natural populations of Pinus koraiensis along its post-glacial colonization route in northeastern China
To understand the genetic mechanisms underlying the endangerment of Pinus koraiensis, we studied the mating system of 49 families of this species in 3 natural populations along its post-glacial colonization route across ~1500 km in northeastern China using the chloroplast simple sequence repeat technique. We analyzed 11 polymorphic loci with clear and repeating bands, and we calculated the mult.. Read More»
Genet. Mol. Res. 14(2): http://dx.doi.org/2015.April.27.26
DOI: http://dx.doi.org/10.4238/2015.April.27.26
Role of inflammatory responses in the pathogenesis of human cerebral aneurysm
We aimed to detect expressional profiles of intracellular cell adhesion molecule-1 (ICAM-1), nuclear factor-kappa B (NF-κB), and monocyte chemoattractant protein-1 (MCP-1) in human cerebral aneurysm, in order to investigate the effect of chronic inflammation on the pathogenesis of cerebral aneurysm. Samples from 40 cases of human cerebral aneurysms diagnosed at our hospital were selected .. Read More»
Genet. Mol. Res. 14(3): 2015.August.7.15
DOI: 10.4238/2015.August.7.15
Molecular cloning and expression analyses of RPS3a gene from mulberry under abiotic stresses and among different mulberry varieties
A full-length cDNA sequence coding ribosomal protein S3a of mulberry tree, which we designated MmRPS3a (GenBank accession No. KR610331), was cloned based on mulberry expressed sequence tags. Sequence analysis showed that the MmRPS3a is 1089 bp long and contains a 80-bp 5'-UTR (untranslated region) and a 220-bp 3'-UTR. Its open reading frame consists of a 789-bp enco.. Read More»
Genet. Mol. Res. 15(2): gmr.15028129
DOI: 10.4238/gmr.15028129
Expression of multidrug resistance 1 and multidrug resistance-related protein 1 in C57BL/6 mice treated with benzene
ATP-binding cassette super family (ABC) proteins are considered key to oncology and pharmacology studies. We examined the effect of benzene on ABC pump protein levels in C57BL/6 mouse bone marrow mononuclear cells. After a 2-week gavage (200 mg/kg, 5 days per week), the number of peripheral leukocytes, lymphocytes and basophils dropped significantly; there was also .. Read More»
Genet. Mol. Res. 12(4): 2013.November.22.11
DOI: 10.4238/2013.November.22.11
Molecular cloning of HSP70 in Mycoplasma ovipneumoniae and comparison with that of other mycoplasmas
Mycoplasma ovipneumoniae, a bacterial species that specifically affects ovine and goat, is the cause of ovine infectious pleuropneumonia. We cloned, sequenced and analyzed heat shock protein 70 (HSP70) (dnaK) gene of M. ovipneumoniae. The full length open reading frame of the M. ovipneumoniae HSP70 gene consists of 1812 nucleotides, with a G+C content of 34.16%, enc.. Read More»
Genet. Mol. Res. 10(2): vol10-2gmr1193
DOI: 10.4238/vol10-2gmr1193
Administration of low-dose cyclosporine alone for the treatment of elderly patients with membranous nephropathy
This study aimed to investigate the effects of administration of low-dose cyclosporine A (CsA) alone and the combination of low-dose CsA and a low-dose hormone for the treatment of elderly patients with membranous nephropathy. We divided 27 patients into two groups as follows: low-dose CsA group (group A) and the group receiving a combination of a low-dose hormone and low-dose CsA (group B). Th.. Read More»
Genet. Mol. Res. 14(1): http://dx.doi.org/2015.March.30.27
DOI: http://dx.doi.org/10.4238/2015.March.30.27
Association of SIRT2 gene polymorphisms with body measurement and growth traits of Qinchuan cattle
Silent information regulator 2 (SIRT2), a member of the Sirtuin family of class III nicotinamide adenine dinucleotide-dependent protein deacetylases, plays an important role in senescence, metabolism, and apoptosis. This study was conducted to detect potential polymorphisms of the bovine SIRT2 gene and explore their relationships with meat quality and body measurement traits (BMTs) in Qinchuan .. Read More»
Genet. Mol. Res. 13(4):
Structural and biochemical characteristics of chitin-binding protein SeCBP66 from Spodoptera exigua (H�¼bner)
Peritrophic membrane proteins are important components of the insect peritrophic membrane. A novel cDNA gene encoding a chitin-binding protein, named secbp66, was identified by immunization screening of the cDNA library of Spodoptera exigua. The full length of secbp66 is 1806 bp, which encodes 602 amino acids. The predicted weight of the protein is 64.2 kDa. Bioinformatic analysis showed that a.. Read More»
Genet. Mol. Res. 15(3): gmr.15038789
DOI: 10.4238/gmr.15038789
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