D.L. Zanette

Publications of : D.L. Zanette

Human Genetics Research Article

Mutational screening in the LDLR gene among patients presenting familial hypercholesterolemia in the Southeast of Brazil

Familial hypercholesterolemia (FH) is a dominant, autosomal disease characterized by high LDL levels in blood plasma, and is caused by a defect in the gene encoding the LDL receptor (LDLR). The clinical diagnosis is based on personal and familial history, physical examination findings, and measures of high LDL cholesterol concentrations. LDLR is a cell-surface glyco.. Read More»

Genet. Mol. Res. 16(3): gmr16039226

DOI: 10.4238/gmr16039226

Plant Genetics Research Article

Microarray profiles of ex vivo expanded hematopoietic stem cells show induction of genes involved in noncanonical Wnt signaling

D.L. Zanette, J.C.C. Lorenzi, R.A. Panepucci, A.R.D. Santos, G.A. Molfetta, A.G. Araujo, W.A. Silva Junior and M.A. Zago

The low number of hematopoietic stem cells (HSC) in umbilical cord blood (UCB) is directly related to increased risk of transplant failure. Effective ex vivo expansion of HSC has been tried for many years, with conflicting results because of the inability to reproduce in vitro HSC proliferation in the same way it occurs in vivo. We compared freshly isolated HSC with their expanded counterparts .. Read More»

Genet. Mol. Res. 12(2): 2013.May.15.1

DOI: 10.4238/2013.May.15.1

Medical Genetics Research Article

Gene expression study related with the intrinsic pathway of apoptosis in bladder cancer by real-time PCR technique

D.F. Barione, F.S.N. Lizarte, P.C. Novais, C.A.M. de Carvalho, F.C.B. Valeri, F.M. Peria, H.F. de Oliveira, D.L. Zanette, W.A. Silva Jr., A.J. Cologna, R.B. Reis, S. Tucci Jr., A.C.P. Martins, D.P.C. Tirapelli and L.F. Tirapelli

We examined the expression of anti-apoptotic genes (XIAP and Bcl-2) and apoptotic genes (cytochrome c, caspase-9, Apaf-1) in tissue samples of patients with superficial bladder cancer. Thirty-two bladder cancer tissue samples (8 papillary urothelial neoplasm of low malignant potential, 10 low-grade, and 14 high-grade) and 8 normal bladder tissue samples from necropsy were used for the study of .. Read More»

Genet. Mol. Res. 12(2): 2013.April.2.4

DOI: 10.4238/2013.April.2.4