E.L. Maistro
Cytotoxic and genotoxic potential of geraniol in peripheral blood mononuclear cells and human hepatoma cell line (HepG2)
Geraniol is an acyclic monoterpene alcohol present in the essential oil of many aromatic plants and is one of the most frequently used molecules by the flavor and fragrance industries. The literature also reports its therapeutic potential, highlighting itself especially as a likely molecule for the development of drugs against cancer. In view of these considerations.. Read More»
Genet. Mol. Res. 16(3): gmr16039777
DOI: 10.4238/gmr16039777
In vitro genotoxicity assessment of caffeic, cinnamic and ferulic acids
Phenols are a large and diverse class of compounds, many of which occur naturally in a variety of food plants; they exhibit a wide range of biological effects, including antibacterial, anti-inflammatory, antiallergic, hepatoprotective, antithrombotic, antiviral, anticarcinogenic, and vasodilatory actions. We examined the genotoxic and clastogenic potential of three phenolic compounds: caffeic, .. Read More»
Genet. Mol. Res. 10(2): vol10-2gmr1278
DOI: 10.4238/vol10-2gmr1278
Genotoxic evaluation of the antimalarial drugs artemisinin and artesunate in human HepG2 cells and effects on CASP3 and SOD1 gene expressions
The malaria treatment recommended by the World Health Organization involves medicines derived from artemisinin, an active compound extracted from the plant Artemisia annua, and some of its derivatives, such as artesunate. Considering the lack of data regarding the genotoxic effects of these compounds in human cells, the objective of this study was to evaluate the cytotoxicity and genotoxicity, .. Read More»
Genet. Mol. Res. 12(3): 2013.July.24.6
DOI: 10.4238/2013.July.24.6
Genotoxicity and mutagenicity of Rosmarinus officinalis (Labiatae) essential oil in mammalian cells in vivo
Genet. Mol. Res. 10(2): vol10-2gmr1481
DOI: 10.4238/vol10-2gmr1481
Absence of mutagenicity effects of Psidium cattleyanum Sabine (Myrtaceae) extract on peripheral blood and bone marrow cells of mice
Cattley guava (Psidium cattleyanum Sabine) is a native fruit of Brazil that is popular both as a sweet food and for its reputed therapeutic properties. We examined whether it could damage DNA using the alkaline single-cell gel electrophoresis (comet assay) and the micronucleus test in leukocytes and in bone marrow cells of mice. P. cattleyanum .. Read More»
Genet. Mol. Res. 7(3): vol7-3gmr475
DOI: 10.4238/vol7-3gmr475
Mutagenicity of the Musa paradisiaca (Musaceae) fruit peel extract in mouse peripheral blood cells in vivo
Plants are a source of many biologically active products and nowadays they are of great interest to the pharmaceutical industry. In the present study, the mutagenic potential of the Musa paradisiaca fruit peel extract was assessed by the single-cell gel electrophoresis (SCGE) and micronucleus assays. Animals were treated orally with three different concentrations of.. Read More»
Genet. Mol. Res. 7(3): vol7-3gmr462
DOI: 10.4238/vol7-3gmr462
In vitro study of the cytotoxic and genotoxic effects of indomethacin-loaded Eudragit�?® L 100 nanocapsules
Indomethacin is a non-steroidal anti-inflammatory agent included in one of the most commonly used drug classes worldwide. The use of this drug results in certain side effects, including gastrointestinal complications. Therefore, there exists a need to develop better methods for the delivery of such drugs into the body, such as those employing nanoparticles. The aim of the present study was to e.. Read More»
Genet. Mol. Res. 15(3): gmr.15038727
DOI: 10.4238/gmr.15038727
Assessment of the potential genotoxic risk of medicinal Tamarindus indica fruit pulp extract using in vivo assays
Tamarindus indica has been used in folk medicine as an antidiabetic, a digestive aid, and a carminative, among other uses. Currently, there is no information in the toxicology literature concerning the safety of T. indica extract. We evaluated the clastogenic and/or genotoxic potential of fruit pulp extract of this plant in vivo in peripheral blood and liver cells of Wistar rats, using the come.. Read More»
Genet. Mol. Res. 8(3): vol8-3gmr630
DOI: 10.4238/vol8-3gmr630
Genotoxicity of the medicinal plant Maytenus robusta in mammalian cells in vivo
Plants belonging to the Celastraceae family have been used in traditional medicine for their analgesic, anti-inflammatory and anti-ulcerogenic properties, among others. Maytenus ilicifolia is the principal species of this family, and is used in the treatment of gastric ulcers. However, owing to its inadequate management in Brazil, the species is becoming extinct and is being substituted with Mayte.. Read More»
Genet. Mol. Res. 11(3): 2012.August.24.9
DOI: 10.4238/2012.August.24.9
Genotoxicity testing of Ambelania occidentalis (Apocynaceae) leaf extract in vivo
Ambelania occidentalis is routinely used in folk medicine for treating gastrointestinal disorders, even though there have been no safety trials. We evaluated the genotoxic potential of hydro-alcoholic extracts of this plant in mice; induced DNA damage was assessed in peripheral blood leukocytes and micronucleus induction was assessed in polychromatic erythrocytes fr.. Read More»
Genet. Mol. Res. 8(2): vol8-2gmr588
DOI: 10.4238/vol8-2gmr588
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