E.M. Souza
Interleukin-18 (rs187238) and glucose transporter 4 (rs5435) polymorphisms in Euro-Brazilians with type 1 diabetes
Type 1 diabetes (T1D) is an autoimmune disease with a strong genetic component that has been associated with several genetic loci. Interleukin 18 (IL-18) is a potent proinflammatory cytokine, which is involved in the innate and adaptive immune responses, and in the pathogenesis of various diseases including T1D. Glucose transporter 4 (GLUT4) is known to be an insuli.. Read More»
Genet. Mol. Res. 16(3): gmr16039755
DOI: 10.4238/gmr16039755
Isolation of a novel lipase from a metagenomic library derived from mangrove sediment from the south Brazilian coast
A novel gene coding for a LipA-like lipase with 283 amino acids and a molecular mass of 32 kDa was isolated and characterized from a metagenomic library prepared from mangrove sediment from the south Brazilian coast. LipA was 52% identical to a lipolytic enzyme from an uncultured bacterium and shared only low identities (≤31%) with lipases/esterases from cultivab.. Read More»
Genet. Mol. Res. 9(1): vol9-1gmr738
DOI: 10.4238/vol9-1gmr738
Diversity of endophytic bacteria in Brazilian sugarcane
Endophytic bacteria live inside plant tissues without causing disease. Studies of endophytes in sugarcane have focused on the isolation of diazotrophic bacteria. We examined the diversity of endophytic bacteria in the internal tissues of sugarcane stems and leaves, using molecular and biochemical methods. Potato-agar medium was used to cultivate the endophytes; 32 i.. Read More»
Genet. Mol. Res. 9(1): vol9-1gmr703
DOI: 10.4238/vol9-1gmr703
Proteins differentially expressed by Shiga toxin-producing Escherichia coli strain M03 due to the biliar salt sodium deoxycholate
Shiga toxin-producing Escherichia coli (STEC) can cause conditions ranging from diarrhea to potentially fatal hemolytic uremic syndrome. Enteropathogen adaptation to the intestinal environment is necessary for the development of infection, and response to bile is an essential characteristic. We evaluated the response of STEC strain M03 to the bile salt sodium deoxycholate through proteomic anal.. Read More»
Genet. Mol. Res. 12(4): 2013.October.24.1
DOI: 10.4238/2013.October.24.1
Leptin (rs7799039) and solute carrier family 30 zinc transporter (rs13266634) polymorphisms in Euro-Brazilian pregnant women with gestational diabetes
Leptin (LEP), a protein that plays a fundamental role in the metabolism of energy reserves, and the solute carrier family 30 A8 zinc transporter (SLC30A8) have been consistently associated with diabetes. Women with gestational diabetes are at moderate risk of developing diabetes type 1 and 2 after pregnancy, in addition to complications to the fetus. We investigated.. Read More»
Genet. Mol. Res. 16(1): gmr16019515
DOI: 10.4238/gmr16019515
Virulence characteristics and antimicrobial susceptibility of uropathogenic Escherichia coli strains
Eight virulence factors associated with uropathogenic Escherichia coli (UPEC) were investigated in 204 clinical isolates of E. coli recovered from urine cultures at counts ≥105. The bacteria were classified into two groups according to the number of leukocytes in urine samples from which they were isolated: group I ≤8 leukocytes/hpf, 104 strains; group II >.. Read More»
Genet. Mol. Res. 10(4): 2011.October.31.5
DOI: 10.4238/2011.October.31.5
Matrix-assisted laser desorption ionization-time of flight mass spectrometry analysis of Escherichia coli categories
The mass profiles of cell-free extracts of 180 commensal and pathogenic strains of Escherichia coli were determined by MALDI-TOF mass spectrometry (MS). While some peaks were highly conserved in all E. coli, several peaks occurred only in some strains, showing heterogeneity among them. We did not detect strain-specific peaks for any of the E. coli categories tested... Read More»
Genet. Mol. Res. 13(1): 2014.January.29.2
DOI: 10.4238/2014.January.29.2
Low prevalence of glucokinase gene mutations in gestational diabetic patients with good glycemic control
Glucokinase (GCK) plays a key role in glucose homeostasis. Gestational diabetes mellitus increases the risk of gestational complications in pregnant women and fetuses. We screened for mutations in coding and flanking regions of the GCK gene in pregnant women with or without gestational diabetes in a Brazilian population. A sample of 200 pregnant women classified as .. Read More»
Genet. Mol. Res. 11(2): 2012.May.18.2
DOI: 10.4238/2012.May.18.2
Development and validation of the first SSR markers for Mimosa scabrella Benth
Mimosa scabrella Benth., popularly known as ‘‘bracatinga’’, is a pioneer and endemic species of Brazil, occurring in Mixed Ombrophilous Forest associated with Brazilian Atlantic Rainforest biomes. It is a fast-growing tree of the Fabaceae family that facilitates the dynamics of ecological succession. SSR development, when there is no genome s.. Read More»
Genet. Mol. Res. 16(1): gmr16019571
DOI: 10.4238/gmr16019571
Culture-independent analysis of endophytic bacterial communities associated with Brazilian sugarcane
Sugarcane is an economically important culture in Brazil. Endophytic bacteria live inside plants, and can provide many benefits to the plant host. We analyzed the bacterial diversity of sugarcane cultivar RB-72454 by cultivation-independent techniques. Total DNA from sugarcane stems from a commercial plantation located in Paraná State was extracted. Partial 16S rRNA genes were amplified .. Read More»
Genet. Mol. Res. 12(4): 2013.October.15.3
DOI: 10.4238/2013.October.15.3
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