F.F. Perazzo
First cytotoxic, genotoxic, and antigenotoxic assessment of Euterpe oleracea fruit oil (aÃ?§aÃ?Â) in cultured human cells
Euterpe oleracea Mart., popularly known as “açaí”, is a tropical fruit from the Amazon region where it has considerable economic importance. Açaí has been used as food and for several medicinal purposes. Despite the widespread use of this fruit, there is a lack of data regarding the safety of using this fruit oil exclusively. .. Read More»
Genet. Mol. Res. 16(3): gmr16039700
DOI: 10.4238/gmr16039700
Genotoxic evaluation of the antimalarial drugs artemisinin and artesunate in human HepG2 cells and effects on CASP3 and SOD1 gene expressions
The malaria treatment recommended by the World Health Organization involves medicines derived from artemisinin, an active compound extracted from the plant Artemisia annua, and some of its derivatives, such as artesunate. Considering the lack of data regarding the genotoxic effects of these compounds in human cells, the objective of this study was to evaluate the cytotoxicity and genotoxicity, .. Read More»
Genet. Mol. Res. 12(3): 2013.July.24.6
DOI: 10.4238/2013.July.24.6
Mutagenicity of the Musa paradisiaca (Musaceae) fruit peel extract in mouse peripheral blood cells in vivo
Plants are a source of many biologically active products and nowadays they are of great interest to the pharmaceutical industry. In the present study, the mutagenic potential of the Musa paradisiaca fruit peel extract was assessed by the single-cell gel electrophoresis (SCGE) and micronucleus assays. Animals were treated orally with three different concentrations of.. Read More»
Genet. Mol. Res. 7(3): vol7-3gmr462
DOI: 10.4238/vol7-3gmr462
Genotoxicity testing of Ambelania occidentalis (Apocynaceae) leaf extract in vivo
Ambelania occidentalis is routinely used in folk medicine for treating gastrointestinal disorders, even though there have been no safety trials. We evaluated the genotoxic potential of hydro-alcoholic extracts of this plant in mice; induced DNA damage was assessed in peripheral blood leukocytes and micronucleus induction was assessed in polychromatic erythrocytes fr.. Read More»
Genet. Mol. Res. 8(2): vol8-2gmr588
DOI: 10.4238/vol8-2gmr588
Lack of clastogenic/genotoxic effects of Baccharis dracunculifolia extract on Swiss mouse peripheral blood cells
Baccharis dracunculifolia De Candole (DC) (Asteraceae) is indigenous throughout southeastern Latin America and is used by local people in traditional medicine. This plant is known to be the source of resin for the highly valued Brazilian green propolis. As no information is available on the safety of high doses of B. dracunculifolia extract, we evaluated the mutagenic potential of high doses of.. Read More»
Genet. Mol. Res. 7(4): vol7-4gmr546
DOI: 10.4238/vol7-4gmr546
The mutagenic potential of Clusia alata (Clusiaceae) extract based on two short-term in vivo assays
We examined the genotoxic and mutagenic effects of a crude extract of Clusia alata (a potential medicinal plant) on peripheral leukocyte and bone marrow cells of mice, using the comet and chromosome aberration assays. Extracts at doses of 1000, 1500 and 2000 mg/kg were administered by gavage, and a positive control, N-nitroso-N-ethylurea (50 mg/kg) was injected intraperitoneally. Peripheral blo.. Read More»
Genet. Mol. Res. 7(4): vol7-4gmr523
DOI: 10.4238/vol7-4gmr523
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