H. Li
Association of interleukin-6 gene polymorphisms and circulating levels with keloid scars in a Chinese Han population
The aim of the present study is to explore the effect of IL-6 gene polymorphisms on the development of keloid scar (KS) in the Chinese Han population. Genotyping of IL-6 was performed by the polymerase chain reaction (PCR), followed by restriction fragment length polymorphism assays (PCR-RFLP). Serum level of IL-6 was measured using enzyme-linked immunosorbent assay.. Read More»
Genet. Mol. Res. 16(2):
miR-1 association with cell proliferation inhibition and apoptosis in vestibular schwannoma by targeting VEGFA
A growing body of research has demonstrated the tumor suppressive function of microRNA (miR)-1 in many cancers. Our study aimed to investigate its role in vestibular schwannoma (VS). We examined miR-1 expression in 95 VS specimens and 79 normal vestibular nerves using quantitative real-time polymerase chain reaction. Moreover, miR-1 mimics, miR-1 inhibitors, and neg.. Read More»
Genet. Mol. Res. 15(4): gmr15048923
DOI: 10.4238/gmr15048923
Association between the TRAIL single nucleotide polymorphism rs1131580 and type 2 diabetes mellitus in a Han Chinese population
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is expressed in different tissues and cells, including the pancreas and lymphocytes, and it can selectively induce apoptosis in tumor cells but not in most normal cells. TRAIL plays critical roles in type 1 diabetes mellitus, and is involved in type 2 diabetes mellitus (T2DM). We recently discovered the association of nonalco.. Read More»
Genet. Mol. Res. 12(3): 2013.September.10.2
DOI: 10.4238/2013.September.10.2
A novel FBN1 heterozygous mutation identified in a Chinese family with autosomal dominant Marfan syndrome
The purpose of this study was to identify the clinical features and mutations in the fibrillin-1 gene (FBN1) in a large Chinese family with autosomal dominant Marfan syndrome (MFS). Seventeen members from a Chinese family of 4 generations were included in the study. All members underwent complete ophthalmic examination. Molecular genetic analysis was performed on all subjects. All exons of FBN1.. Read More»
Genet. Mol. Res. 14(2): http://dx.doi.org/2015.April.27.27
DOI: http://dx.doi.org/10.4238/2015.April.27.27
Mating system patterns of natural populations of Pinus koraiensis along its post-glacial colonization route in northeastern China
To understand the genetic mechanisms underlying the endangerment of Pinus koraiensis, we studied the mating system of 49 families of this species in 3 natural populations along its post-glacial colonization route across ~1500 km in northeastern China using the chloroplast simple sequence repeat technique. We analyzed 11 polymorphic loci with clear and repeating bands, and we calculated the mult.. Read More»
Genet. Mol. Res. 14(2): http://dx.doi.org/2015.April.27.26
DOI: http://dx.doi.org/10.4238/2015.April.27.26
Cloning and expression of an APETALA1-like gene from Nelumbo nucifera
The objective of this study was to clone the full-length cDNA of the APETALA1 (AP1) gene from lotus and analyze its sequence and expression pattern. The full-length cDNA sequence of the NnAP1 gene was amplified from the petals of Nelumbo nucifera ‘Hongxia’ using RT-PCR and rapid amplification of cDNA ends. Bioinformatic methods were used to analyze the sequence characteristics of th.. Read More»
Genet. Mol. Res. 14(2): 2015.June.18.24
DOI: 10.4238/2015.June.18.24
Characterization of Chinese eggplant isolates of the fungal pathogen Verticillium dahliae from different geographic origins
Verticillium dahliae is a fungal pathogen that causes wilt disease in a wide range of host plants. Characterization of virulence, morphological, and molecular variations among V. dahliae isolates from different geographic origins is essential for any breeding program aimed at producing plant cultivars resistant to this disease. We characterized virulence variation among V. dahliae isolates from Ch.. Read More»
Genet. Mol. Res. 12(1): 2013.January.24.11
DOI: 10.4238/2013.January.24.11
Development and characterization of microsatellite loci in Brasenia schreberi (Cabombaceae) based on the next-generation sequencing
To understand genetic variability of the endangered aquatic herb Brasenia schreberi (Cabombaceae), we describe 31 microsatellite markers obtained using next-generation sequencing. A total of 24 individuals from the population of Jackson Lake, USA, were genotyped for each marker. Twenty-eight markers were polymorphic. The number of alleles per locus ranged from 1 to .. Read More»
Genet. Mol. Res. 15(2): gmr.15027886
DOI: 10.4238/gmr.15027886
Developmental methylation pattern regulates porcine GPR120 expression
DNA methylation is an important component of the epigenetic machinery and plays a critical role in transcriptional regulation. It mostly occurs in CpG abundant regions, known as CpG islands (CGIs). G protein-coupled receptor 120 (GPR120) functions as an omega-3 fatty acid receptor and is involved in multiple-biological processes, including lipogenesis. Herein, we show that GPR120 is highly expr.. Read More»
Genet. Mol. Res. 15(1): gmr.15014240
DOI: 10.4238/gmr.15014240
Effect of Jianpi Bushen prescription on the expression of SHP-1 and apoptosis-related genes in chemically damaged model mice
We investigated the effect of Jianpi Bushen prescription (JBP) on the expression of the SHP-1 and apoptosis-related genes in chemically damaged model mice and a compound e-jiao slurry (EJS) group (positive control). Kunming mice received an abdominal injection of 100 mg/kg cyclophosphamide once a day for 3 consecutive days to induce chemical damage. The mice underwe.. Read More»
Genet. Mol. Res. 13(3): 2014.August.7.11
DOI: 10.4238/2014.August.7.11
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