H. Ren
Comparison of physical and chemical characteristics of collagen from the skin of cod (Gadus macrocephaius)
Acid and pepsin-soluble collagen (ASC and PSC, respectively) were extracted from cod (Gadus macrocephaius) skin, and yields of 37.36 and 55.96% were obtained for ASC and PSC, respectively. The total yield of ASC and PSC was 93.92%, based on the lyophilized dry weight, which is higher than that obtained from other sources. Electrophoresis revealed that both ASC and P.. Read More»
Genet. Mol. Res. 16(2): gmr16027940
DOI: 10.4238/gmr16027940
Circulating miR-125b as a biomarker of Ewing�s sarcoma in Chinese children
Previous studies indicated that microRNA-125b (miR-125b) has an important role in the progression of Ewing’s sarcoma (ES). The purpose of the current study was to examine expression changes of miR-125b in the serum of ES patients and evaluate if the expression level of miR-125b could serve as a new biomarker for ES. This study was performed on patients who underwent surgical resection at .. Read More»
Genet. Mol. Res. 14(4): 2015.December.29.12
DOI: 10.4238/2015.December.29.12
Effect of lipoic acid combined with paclitaxel on breast cancer cells
Breast cancer is the most common gynecologic tumor globally that threatens women’s health. Lipoic acid is a type of antioxidant that can alleviate oxidative stress damage. Studies showed that lipoic acid could inhibit the proliferation of tumor cells in cervical cancer and colon cancer. This paper intends to explore the combined effect of lipoic acid and paclitaxel on breast cancer cells... Read More»
Genet. Mol. Res. 14(4): 2015.December.22.18
DOI: 10.4238/2015.December.22.18
Dysregulation of TFDP1 and of the cell cycle pathway in high-grade glioblastoma multiforme: a bioinformatic analysis
Despite extensive research, the prognosis of high-grade glioblastoma multiforme (GBM) has improved only slightly because of the limited response to standard treatments. Recent advances (discoveries of molecular biomarkers) provide new opportunities for the treatment of GBM. The aim of the present study was to identify diagnostic biomarkers of high-grade GBM. First, .. Read More»
Genet. Mol. Res. 15(2): gmr.15027646
DOI: 10.4238/gmr.15027646
Hypolipidemic effect of safflower yellow and primary mechanism analysis
We examined the hypolipidemic effect of safflower yellow (SY) on hyperlipidemic mice and its influence on the biological synthesis of cholesterol in cells. Over 4 weeks, the levels of total cholesterol, triglyceride, low-density lipoprotein cholesterol, and highdensity lipoprotein cholesterol in serum were detected using a kit; mouse liver samples were acquired for paraffin sections, and mouse .. Read More»
Genet. Mol. Res. 14(2): 2015.June.9.14
DOI: 10.4238/2015.June.9.14
Single nucleotide polymorphisms of Ã?Â?6-desaturase and Elovl5 segments and their associations with common carp (Cyprinus carpio) growth traits
Highly unsaturated fatty acids (HUFAs) are crucial for the nutritional health, physiology, and reproduction of vertebrates. The Δ6-desaturase and Elovl5 elongase genes produce essential enzymes in the biosynthetic pathway of HUFAs. Single nucleotide polymorphism (SNP) analysis of genes functionally related to the growth traits of the common carp (Cyprinus carpio var. Jian) can provide use.. Read More»
Genet. Mol. Res. 14(4): 2015.October.21.4
DOI: 10.4238/2015.October.21.4
Efficacy of Artemisia annua polysaccharides as an adjuvant to hepatitis C vaccination
The traditional Chinese medicine Artemisia annua can prevent and treat hepatitis following an unclear mechanism. The aim of this study was to evaluate the effects of A. annua polysaccharides (AAP) on hepatitis C virus (HCV). A pcDNA3.1/NS3 expression vector was constructed. Ninety female BALB/c mice were randomly divided into six groups: high-dose AAP (1 mg/mL) + HCV/NS3 plasmid; middle-dose AA.. Read More»
Genet. Mol. Res. 14(2): 2015.May.11.29
DOI: 10.4238/2015.May.11.29
Diversity resistance to Puccinia striiformis f. sp Tritici in rye chromosome arm 1RS expressed in wheat
The 1BL.1RS wheat-rye translocation contained in the Russian cultivar Aurora has been the most widespread alien translocation in wheat-breeding programs all over the world. However, following the prevalence of new biotypes of the pathogens, disease-resistance genes in this translocation chromosome have been overcome and consequently they have been eliminated in modern wheat-breeding programs. I.. Read More»
Genet. Mol. Res. 13(4):
Integrated microRNA-mRNA analysis of pancreatic ductal adenocarcinoma
The main aim of this study was to explore the underlying molecular mechanisms and potential target molecules of pancreatic adenocarcinoma. The miRNA (GSE32678) and mRNA (GSE32676) expression profiles of patients with pancreatic ductal adenocarcinoma and healthy controls were downloaded from the Gene Expression Omnibus database. Differentially expressed miRNA and differentially expressed genes w.. Read More»
Genet. Mol. Res. 14(3): http://dx.doi.org/2015.August.28.14
DOI: http://dx.doi.org/10.4238/2015.August.28.14
Lenalidomide affect expression level of cereblon protein in multiple myeloma cell line RPMI8226
We investigated the mechanisms of action of immunomodulatory drug (lenalidomide) on the protein expression of cereblon (CRBN) and their therapeutic targets in the multiple myeloma cell line RPMI8226. The multiple myeloma cell line RPMI8226 was cultured and treated with different concentrations of lenalidomide and bortezomib to determine the proliferation inhibition rate, apoptosis rate, and pro.. Read More»
Genet. Mol. Res. 14(4): 2015.October.28.19
DOI: 10.4238/2015.October.28.19
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