H. Wang
Role of IL17A rs2275913 and rs3748067 polymorphisms in the risk cervical cancer
Cervical cancer is a serious public health problem and is associated with high cancer-related mortality in females worldwide. The expression of IL17A can increase the migration and invasiveness of cervical cancer cells by activating the NF-κB signal pathway. Single-nucleotide polymorphisms (SNPs) can alter gene function and protein expression. We examined the .. Read More»
Genet. Mol. Res. 16(3): gmr16038826
DOI: 10.4238/gmr16038826
Effects of sodium lactate Ringerâ�?�?s injection on transfection of human protein kinase C-�?± antisense oligonucleotide in A549 lung cancer cells
In the present study, we evaluated the effects of four solutions [Dulbecco’s modified Eagle’s medium (DMEM), sodium lactate Ringer’s injection (SLRI), phosphate-buffered saline (PBS), and NaCl] on the transfection of the human protein kinase C-a antisense oligonucleotide (PKC-a ASO) aprinocarsen in human lung carcinoma A549 cells. Specifically, SLRI, DMEM, PBS, or NaCl were us.. Read More»
Genet. Mol. Res. 15(3): gmr.15037650
DOI: 10.4238/gmr.15037650
Improved protocol for extracting genomic DNA from frozen formalin-fixed tissue resulting in high-quality whole mtDNA
Formalin fixation and paraffin embedding is widely used for convenient and long-term storage of tumor tissue and precious sources to perform genetic studies. However, DNA fragmentation is one of the major flaws of genomic DNA isolation from formalin fixation tissues, which limits its further usage. Here, we present an improved method for isolating high-quality genomic DNA from formalin fixation.. Read More»
Genet. Mol. Res. 15(3): gmr.15037972
DOI: 10.4238/gmr.15037972
Cloning and expression analysis of PpSUT2 encoding a sucrose transporter in pear
A 1794-bp cDNA fragment was amplified from mRNA isolated from pear (Pyrus pyrifolia NaKai. Cuiguan) leaves by using primers based on the sequences generated during the analysis of the pear transcriptome. The 597-amino acid sequence encoded by the cDNA was compared with the sequences in GenBank, and it was found to be similar to that of members of the sucrose-proton co-transporter family. The hy.. Read More»
Genet. Mol. Res. 13(4):
Inhibitory effect of microRNA-24 on fatty acid-binding protein expression on 3T3-L1 adipocyte differentiation
We examined the effect of microRNAs on 3T3-L1 adipocyte differentiation and expression of adipocyte-specific gene fatty acid-binding protein 4 (FABP4). We screened and identified adipo-related microRNAs during 3T3-L1 adipocyte differentiation with a microRNA microarray. High expression plasmids of miR-24 and miR-21 were constructed and transfected into 3T3-L1 preadipocytes by lipofectamine. The.. Read More»
Genet. Mol. Res. 13(4): 2013.November.7.1
DOI: 10.4238/2013.November.7.1
Effects of high intensity exhaustive exercise on SOD, MDA, and NO levels in rats with knee osteoarthritis
The aim of this study was to investigate the impact of high intensity exhaustive exercise on nitric oxide (NO), malondialdehyde (MDA), and superoxide dismutase (SOD) expression in rats with knee osteoarthritis. Sprague Dawley rats were randomly divided into control (N = 5) and model (N = 35) groups; the model group was further divided into quiet (N = 5), low- (N = 1.. Read More»
Genet. Mol. Res. 14(4): 2015.October.16.3
DOI: 10.4238/2015.October.16.3
Genetic variations in the Wnt signaling pathway affect lung function in asthma patients
Identifying genetic determinants for lung function is important in providing insight into the pathophysiology of asthma. The Wnt signal pathway plays a role in lung development and in asthma pathogenesis. However, whether genetic polymorphisms of Wnt signal pathway are associated with lung function in asthma patients remain unclear. We genotyped 2 single nucleotide polymorphisms (SNPs, rs292997.. Read More»
Genet. Mol. Res. 12(2): 2013.January.4.1
DOI: 10.4238/2013.January.4.1
Expression and significance of miR-21 in multiple myeloma patients
The aim of the present study is to examine the expression level of peripheral mir-21 in multiple myeloma (MM) patients and to determine its clinical significance. MM patients (30), monoclonal gammopathy of undetermined significance (MGUS) patients (14), and normal controls (20) were recruited to determine the serum level of β2-MG, IgA and IgM, IgG, λ, κ, TP, ALB, Hb, LDH, and .. Read More»
Genet. Mol. Res. 15(1): gmr.15016892
DOI: 10.4238/gmr.15016892
Temporal and spatial expression of Smads and their correlation with YAP1 expression in sheep
The temporal and spatial patterns of Smad and Yes-associated protein 1 (YAP1) expression were investigated in skeletal muscle (gastrocnemius muscle and extensor digitorum longus) at different growth stages (2 days old, 2 and 6 months old) in Hu sheep. Smads were differentially expressed in sheep skeletal muscle, with high expression in the gastrocnemius muscle and lower expression in the extens.. Read More»
Genet. Mol. Res. 15(3): gmr.15037715
DOI: 10.4238/gmr.15037715
Module function and two-way clustering analysis of Epstein-Barr virus-related nasopharyngeal cancer
This study sought to identify and characterize the function of genes as diagnostic markers for Epstein-Barr virus (EBV)-related nasopharyngeal cancer (NPC). The gene expression profile of GSE13597 was downloaded from the Gene Expression Omnibus database, which included 28 EBV-related NPC gene expression profile data sets, 25 disease samples, and 3 control samples. D.. Read More»
Genet. Mol. Res. 13(1): http://dx.doi.org/2014.March.17.10
DOI: http://dx.doi.org/10.4238/2014.March.17.10
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