H. Yan
mRNA and protein expression levels of four candidate genes for ear size in Erhualian and Large White pigs
Porcine ear size is an important characteristic for distinguishing among pig breeds. In a previous genome-wide association study of porcine ear size, LEM domain-containing 3 (LEMD3), methionine sulfoxide reductase B3 (MSRB3), high mobility group AT-hook 2 (HMGA2), and Wnt inhibitory factor 1 (WIF1) were implicated as important candidate genes for ear size. This stud.. Read More»
Genet. Mol. Res. 16(2): gmr16029252
DOI: 10.4238/gmr16029252
Association between ERCC1 and XPF polymorphisms and risk of colorectal cancer
We conducted a hospital-based case-control study to evaluate the association between polymorphisms in excision repair cross-complementing group 1-xeroderma pigmentosum group F (ERCC1-XPF) variants and the risk of colorectal cancer in a Chinese population. Genotyping of the ERCC1 rs2298881 and rs11615 and XPF rs2276466 polymorphisms were detected by polymerase chain reaction-restriction fragment le.. Read More»
Genet. Mol. Res. 14(1): 2015.January.30.13
DOI: 10.4238/2015.January.30.13
Correlation of the TCF7L2 (rs7903146) polymorphism with an enhanced risk of type 2 diabetes mellitus: a meta-analysis
Increasing evidence has demonstrated that a transcription factor 7-like 2 (TCF7L2) polymorphism (rs7903146) is significantly associated with type 2 diabetes mellitus (T2DM); however, limited sample size and variance of ethnicity in the studies investigating this association have led to conflicting reports regarding its role. Therefore, a comprehensive meta-analysis was conducted to quantitative.. Read More»
Genet. Mol. Res. 15(3): gmr.15037969
DOI: 10.4238/gmr.15037969
Molecular analysis and frequency of Staphylococcus aureus virulence genes isolated from bloodstream infections in a teaching hospital in Tianjin, China
Staphylococcus aureus is an important cause of bloodstream infections worldwide. We examined the prevalence of genes that encode erythromycin ribosome methylase and bacterial toxins in S. aureus collected from bloodstream infections. Sixty different S. aureus isolates were obtained from blood cultures of patients who were admitted to a Teaching Hospital in Tianjin from January 2006 to August 20.. Read More»
Genet. Mol. Res. 12(1): 2013.March.11.12
DOI: 10.4238/2013.March.11.12
Wilms' tumor suppressor gene mutations in girls with sporadic isolated steroid-resistant nephrotic syndrome
Mutations in the Wilms' tumor suppressor gene (WT1) can lead to syndromic forms of steroid-resistant nephrotic syndrome (SRNS) such as Denys-Drash or Frasier syndrome and can cause isolated SRNS. A mutation within WT1 is a frequent cause of sporadic isolated SRNS in girls. In a worldwide cohort of girls, the rate of occurrence was 10.8%. Previous reports have indica.. Read More»
Genet. Mol. Res. 13(4): 2013.December.4.5
DOI: 10.4238/2013.December.4.5
Whole-genome duplications contributed to the expansion of cytochrome b5 genes in Paramecium tetraurelia
Cytochrome b5 (cyt b5) genes encode ubiquitous electron transport hemoproteins found in animals, plants, fungi, and purple bacteria. However, little is known about their evolutionary history in genomes so far. Here, we conducted an extensive genome-wide survey of cyt b5 genes in 20 representative model species and identified 310 of these genes. Both the absolute number and relative proportion o.. Read More»
Genet. Mol. Res. 12(2): 2013.January.9.1
DOI: 10.4238/2013.January.9.1
Construction of a primary DNA fingerprint database for cotton cultivars
Forty core primers were used to construct a DNA fingerprint database of 132 cotton species based on multiplex fluorescence detection technology. A high first successful ratio of 99.04% was demonstrated with tetraplex polymerase chain reaction. Forty primer pairs amplified a total of 262 genotypes among 132 species, with an average of 6.55 per primer and values of polymorphism information conten.. Read More»
Genet. Mol. Res. 12(2): 2013.January.30.3
DOI: 10.4238/2013.January.30.3
Effects of rifampicin on osteogenic differentiation and proliferation of human mesenchymal stem cells in the bone marrow
This study was designed to investigate the effect of different concentrations of rifampicin on osteogenic differentiation and proliferation of mesenchymal stem cells (MSCs) in human bone marrow. Rifampicin treatment at 0, 4, 8, 16, 32, 64, and 128 mg/mL was applied throughout the whole process, from stromal cells purified from human bone marrow to differentiated bon.. Read More»
Genet. Mol. Res. 13(3): 2014.August.25.3
DOI: 10.4238/2014.August.25.3
Multifocal central nervous system hemangioblastoma: a case report and review of the literature
An effective therapy for multifocal central nervous system hemangioblastoma (CNS HB) is needed. Here, we report a case of multifocal CNS HB. A 43-year-old man was diagnosed with CNS HB by enhanced computed tomography and magnetic resonance imaging. Six solid tumors and one cystic nodule were detected in his cerebellum. The patient underwent three surgeries followed .. Read More»
Genet. Mol. Res. 13(3): 2014.September.29.3
DOI: 10.4238/2014.September.29.3
Development and characterization of polymorphic microsatellite loci in the sea cucumber Holothuria leucospilota
Holothuria leucospilota is a tropical holothurian species that is widely distributed in the tropical and sub-tropical India-Western Pacific Region. Eight polymorphic microsatellite loci were developed from H. leucospilota by using the protocol fast isolation by amplified fragment length polymorphism of sequences containing repeats and tested in 30 individuals from Hainan Island in China. The nu.. Read More»
Genet. Mol. Res. 14(1): 2015.January.26.8
DOI: 10.4238/2015.January.26.8
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