H.Y. Zhang

Characterization and development of 56 EST-SSR markers derived from the transcriptome of Odontobutis potamophila

• P.P. Wang
• M. Ren
• S.Q. Chen
• S.W. Yin
• C. Zhao
• H.Y. Zhang
• X.R. Li
• Q.Q. Cao
• G.Q. Zhou

Expressed sequence tags (ETSs) are the sources of microsatellite development. In this study, we isolated and characterized microsatellite markers for Odontobutis potamophila by using Illumina RNA-sequencing. We sequenced a large number of ESTs and screened 200 potential microsatellites. Consequently, a total of 56 novel polymorphic mic.. Read More»

Genet. Mol. Res. 16(2): gmr16029129

DOI: 10.4238/gmr16029129

De novo interstitial deletion in the long arm of chromosome 11: a case report

L.L. Li, H.G. Zhang, X.G. Shao, J.C. Gao, H.Y. Zhang and R.Z. Liu

The 11q terminal deletion disorder is a rare genetic disorder associated with numerous clinical features. A few case reports have been made about de novo interstitial deletion of chromosome 11q. However, due to the heterogeneity in size and position of the deletions, a clear genotype-phenotype correlation is not easily made. Here we report a case interstitial 20.5-M.. Read More»

Genet. Mol. Res. 15(2):

Male carriers of balanced reciprocal translocations in Northeast China: sperm count, reproductive performance, and genetic counseling

H.G. Zhang, R.X. Wang, L.L. Li, W.T. Sun, H.Y. Zhang and R.Z. Liu

Balanced chromosomal translocations in men can cause failure of spermatogenesis owing to meiotic impairment. Male carriers may exhibit normozoospermia, although clinical manifestations can include oligozoospermia or azoospermia, oligozoospermia or normozoospermia. Here, we reported the characteristics of balanced reciprocal translocations in men from northeastern China, and explored the relatio.. Read More»

Genet. Mol. Res. 14(4): 2015.December.28.28

DOI: 10.4238/2015.December.28.28

Elevated TrkA receptor expression is associated with all-trans retinoic acid-induced neuroblastoma differentiation

Q. Gao, C.F. Chen, Q. Dong, L. Hou, X. Chen, Y.L. Zhi, X. Li, H.T. Lu and H.Y. Zhang

Neuroblastoma is the most common and one of the deadliest among pediatric tumors; however, a subset of infants with neuroblastoma display spontaneous regression. The mechanism of spontaneous regression remains to be elucidated. TrkA plays an essential role in the differentiation and functionality of neurons; abundant TrkA expression is associated with favorable prognosis of neuroblastoma. All-t.. Read More»

Genet. Mol. Res. 14(4): 2015.October.26.15

DOI: 10.4238/2015.October.26.15

Hypoxia enhances periodontal ligament stem cell proliferation via the MAPK signaling pathway

Y. He, C.X. Jian, H.Y. Zhang, Y. Zhou, X. Wu, G. Zhang and Y.H. Tan

There is high incidence of periodontal disease in high-altitude environments; hypoxia may influence the proliferation and clone-forming ability of periodontal ligament stem cells (PDLSCs). The MAPK signaling pathway is closely correlated with cell proliferation, differentiation, and apoptosis. Thus, we isolated and cultured PDLSCs under hypoxic conditions to clarify.. Read More»

Genet. Mol. Res. 15(4): gmr15048965

DOI: 10.4238/gmr15048965

miR-146a and miR-196a2 polymorphisms in ovarian cancer risk

X.C. Sun, A.C. Zhang, L.L. Tong, K. Wang, X. Wang, Z.Q. Sun and H.Y. Zhang

We investigated the relationship between miR-146a and miR-196a2 genetic polymorphisms and development of ovarian cancer in a Chinese population. A total of 134 patients and 227 control subjects were involved in our study between January 2012 and October 2014 from China-Japan Union Hospital of Jilin University. Genotyping of miR-146a and miR-196a2 was accomplished by.. Read More»

Genet. Mol. Res. 15(3): gmr.15038468

DOI: 10.4238/gmr.15038468

Effect of everolimus on the expression of Ki-67 and caspase-3 in patients with neuroendocrine tumors

H.Y. Zhang, X.B. Cheng, Y. Li, L.D. Jin, H.P. Yin

Tumors, especially neuroendocrine tumors (NETs), can cause adverse effects on human health. The expression and significance of Ki-67 and caspase-3 in NET remain to be further explored. Everolimus is an important drug used for the treatment of NETs. In this study, we aimed to investigate whether everolimus exerts anti-tumor effects by suppressing the expression of Ki.. Read More»

Genet. Mol. Res. 16(1): gmr16019486

DOI: 10.4238/gmr16019486

Association of the genes for tumor necrosis factor-�?± and myelin basic protein with delayed encephalopathy after acute carbon monoxide poisoning

S.G. Li W.Q. Li J.K. Wang H.Y. Zhang W. Li P. Zhang X.H. Wang H.X. Zhang J.P. Gu R.J. Gu

There is structural damage to myelin and secondary immune injury in the development of delayed encephalopathy after acute carbon monoxide (CO) poisoning (DEACMP). In order to assess the role of genetic factors in this mechanism, we studied the association between tumor necrosis factor-α308 (TNF-α308) and myelin basic protein (MBP) 5ê�?�?-side tetranucleotide repetitive sequence (TG.. Read More»

Genet. Mol. Res. 11(4): 2012.December.19.1

DOI: 10.4238/2012.December.19.1

Balanced reciprocal translocation at amniocentesis: cytogenetic detection and implications for genetic counseling

H.G. Zhang, X.Y. Zhang, H.Y. Zhang, T. Tian, S.B. Xu and R.Z. Liu

Balanced translocation is a common structural chromosomal rearrangement in humans. Carriers can be phenotypically normal but have an increased risk of pregnancy loss, fetal death, and the transmission of chromosomal abnormalities to their offspring. Existing prenatal screening technologies and diagnostic procedures fail to detect balanced translocation, so genetic counseling for carriers remain.. Read More»

Genet. Mol. Res. 15(3): gmr.15038556

DOI: 10.4238/gmr.15038556

Analysis of microbial diversity and niche in rhizosphere soil of healthy and diseased cotton at the flowering stage in southern Xinjiang

F.G. Luan, L.L. Zhang, Y.Y. Lou, L. Wang, Y.N. Liu and H.Y. Zhang

Understanding how microbial community composition and diversity respond to continuous cropping obstacle is not well understood. However, determining the community composition vs assessing the diversity of molecular operational taxonomic units is often difficult. In this study, we focused on the microbial diversity and niche differentiation in rhizosphere soils between healthy and diseased cotto.. Read More»

Genet. Mol. Res. 14(1): 2015.March.6.7

DOI: 10.4238/2015.March.6.7