I.D.C.G. Silva

Publications of : I.D.C.G. Silva

Animal Genetics Research Article

Identification of differentially expressed genes in pathways of cerebral neurotransmission of anovulatory mice

Polycystic ovary syndrome is the classic example of loss of functional cyclicity and anomalous feedback. In this case, the excessive extra-glandular production and conversion of androgens to estrogens are the pathophysiological basis of the chronic anovulation. The literature describes an experimental model of the polymicrocystic ovary in obese diabetic mice with in.. Read More»

Genet. Mol. Res. 16(3): gmr16039622

DOI: 10.4238/gmr16039622

Human Genetics Research Article

Analysis of CYP1A1 and COMT polymorphisms in women with cervical cancer

J.P. Kleine, C.M. Camargo-Kosugi, C.V. Carvalho, F.C. Silva and I.D.C.G. Silva

The aim of this case-control study was to obtain a comprehensive panel of genetic polymorphisms present only in genes (cytochrome P-450 1A1 - CYP1A1 and catechol-O-methyl transferase - COMT) within the metabolic pathway of sex steroids and determine their possible associations with the presence or absence of cervical cancer. Genotypes of 222 women were analyzed: a) 81 with cancer of the cervix .. Read More»

Genet. Mol. Res. 14(4): 2015.December.29.3

DOI: 10.4238/2015.December.29.3

Human Genetics Research Article

Human papillomavirus infection in Brazilian women with normal cervical cytology

P.M. Miranda, B.C.V. Pitol, M.S. Moran, N.N.T. Silva, P.M. Felix, J.L. Lima-Filho, C.M. Carneiro, I.D.C.G. Silva, R.F. Carvalho, A.A. Lima, W. BeÃÆÃÂ§ak and R.C. Stocco

We examined the prevalence of human papillomavirus (HPV) infection in a sample of Brazilian women presenting normal cervical cytology. Possible interactions between patient characteristics and HPV infection were analyzed in order to provide background data to improve cervical cancer screening and prophylaxis. Cervical samples of 399 women, received for routine evalu.. Read More»

Genet. Mol. Res. 11(2): http://dx.doi.org/2012.June.29.8

DOI: http://dx.doi.org/10.4238/2012.June.29.8

Human Genetics Research Article

Polymorphisms in CYP17, COMT, and ESR1 genes in women after menopause and association with bone mineral density

C.G. GonÃÆÃÂ§alves, B.C. Almeida, C.M. Camargo-Kosugi, A.M.M. Costa, I.D.C.G. Silva, M.A. Haidar

In this study, we evaluated genetic factors related to the mineral density during post-menopause. We evaluated 110 women in the first 5 years post-menopause, without previous hormone replacement therapy. Cytochrome P450 17 (CYP17) (rs743572), catechol-O-methyl transferase (COMT) (rs4680), and estrogen receptor 1 (ESR1) (rs9322331) were examined for the presence of p.. Read More»

Genet. Mol. Res. 14(4): 2015.December.1.32

DOI: 10.4238/2015.December.1.32

Human Genetics Research Article

Analysis of polymorphisms in codons 11, 72 and 248 of TP53 in Brazilian women with breast cancer

B.C. Almeida1, J.P.F.O. Kleine1, C.M. Camargo-Kosugi1,2, M.R. Lisboa1,C.N. FranÃÆÃÂ§a3, J.P. FranÃÆÃÂ§a4 and I.D.C.G. Silva1

The association between TP53 gene polymorphisms and breast cancer (BC) in Brazilian women is a controversial topic. In this cross-sectional study, we evaluated the association between clinical pathological variables and three polymorphisms (TP53*11, TP53*72, and TP53*248) in BC patients and controls. Genomic DNA was extracted from the blood cells of 393 participants; the cancer-free control sub.. Read More»

Genet. Mol. Res. 15(1): gmr.15017055

DOI: 10.4238/gmr.15017055

Human Genetics Research Article

TP53 gene polymorphisms at codons 11, 72, and 248 and association with endometriosis in a Brazilian population

C.M. Camargo-Kosugi, P. DÃÂ¢Ãâ¬Ãâ¢Amora, J.P.F.O. Kleine, C.V. Carvalho, H. Sato, E. Schor and I.D.C.G. Silva

We evaluated the association between TP53 gene polymorphisms and endometriosis in Brazilian women. Genomic DNA was extracted from swabs of buccal cells collected from hospital patients. TP53 gene polymorphisms were investigated at three codons: TP53*11 Glu/Gln or Lys (GAG->CAG or AAG), TP53*72 Arg/Pro (CCG->CCC), and TP5.. Read More»

Genet. Mol. Res. 13(3): 2014.August.26.1

DOI: 10.4238/2014.August.26.1