J. Liang
mRNA and protein expression levels of four candidate genes for ear size in Erhualian and Large White pigs
Porcine ear size is an important characteristic for distinguishing among pig breeds. In a previous genome-wide association study of porcine ear size, LEM domain-containing 3 (LEMD3), methionine sulfoxide reductase B3 (MSRB3), high mobility group AT-hook 2 (HMGA2), and Wnt inhibitory factor 1 (WIF1) were implicated as important candidate genes for ear size. This stud.. Read More»
Genet. Mol. Res. 16(2): gmr16029252
DOI: 10.4238/gmr16029252
Screening and identification of peritoneal metastasis-related genes of gastric adenocarcinoma using a cDNA microarray
With the aim of identifying peritoneal metastasis-related genes in gastric cancer, we performed a broad analysis of differential gene expression between the parental cell line GC9811 and its highly metastatic peritoneal counterpart, cell line GC9811-P. Two fluorescent cDNA probes, labeled with Cy3 and Cy5 dyes, were prepared from GC9811 and GC9811-P mRNA samples by .. Read More»
Genet. Mol. Res. 11(2): 2012.June.25.1
DOI: 10.4238/2012.June.25.1
Keloid microRNA expression analysis and the influence of miR-199a-5p on the proliferation of keloid fibroblasts
The purpose of this study was to identify microRNAs (miRNAs) involved in keloid formation and determine their influence on the proliferation of keloid fibroblasts (KFs). Eight specimens each of resected keloid tissue and normal skin tissue were collected. miRNAs that are differentially expressed in keloid tissue and normal skin were detected using an miRNA microarra.. Read More»
Genet. Mol. Res. 13(2): 2014.April.14.2
DOI: 10.4238/2014.April.14.2
Serotonin receptor 2C gene polymorphism associated with post-stroke depression in Chinese patients
The serotonin receptor 2C (HTR2C) gene has been shown to play a pivotal role in major depression. We examined the association between post-stroke depression (PSD) and polymorphism in HTR2C. A cohort of 223 patients with acute lacunar stroke admitted to the stroke unit of a university-affiliated regional hospital in Hong Kong was recruited. Three months after the onset of the index stroke, a res.. Read More»
Genet. Mol. Res. 12(2): 2013.May.13.8
DOI: 10.4238/2013.May.13.8
Association of NT-proBNP and interleukin-17 levels with heart failure in elderly patients
Pro-B-type natriuretic peptide (NT-proBNP) and interleukin-17 (IL-17) are involved in the pathophysiological processes of heart failure; however, the exact role of IL-17 is not clear. We explored the relationship between IL-17 and NT-proBNP, as a clinical parameter, in heart failure. The whole blood IL-17 and NT-proBNP levels and the readmission rates in 70 patients.. Read More»
Genet. Mol. Res. 15(2): gmr.15028014
DOI: 10.4238/gmr.15028014
Analysis of interleukin 19 serum levels and single nucleotide polymorphisms in systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disease that affects multiple organs and diminishes a patients’ quality of life. It has been suggested that interleukin 19 (IL-19) is engaged in intercellular signal transduction, which is related to the immune response and the local inflammatory reaction. Single nucleotide polymorphisms (SN.. Read More»
Genet. Mol. Res. 15(2): gmr.15028007
DOI: 10.4238/gmr.15028007
Clinical analysis of penehyclidine hydrochloride combined with hemoperfusion in the treatment of acute severe organophosphorus pesticide poisoning
This study aimed to observe the clinical curative effect of penehyclidine hydrochloride (PHC) combined with hemoperfusion in treating acute severe organophosphorus pesticide poisoning. We randomly divided 61 patients with severe organophosphorus pesticide poisoning into an experimental group (N = 31) and a control group (N = 30), and we compared the coma-recovery time, mechanical ventilation ti.. Read More»
Genet. Mol. Res. 14(2): 2015.May.11.24
DOI: 10.4238/2015.May.11.24
Association between MYC rs9642880[T] allele and bladder cancer risk: a meta-analysis
A single nucleotide polymorphism of MYC rs9642880 (G>T) at the 8q24.1 locus is thought to be associated with bladder cancer risk based on the results of genome-wide association studies, but the results remain inconclusive. To assess the association between rs9642880[T] allele and bladder cancer risk, we performed this meta-analysis including 18 case-control studies and involving 23,084 cases.. Read More»
Genet. Mol. Res. 14(4): 2015.November.18.39
DOI: 10.4238/2015.November.18.39
Porcine MAP3K5 analysis: molecular cloning, characterization, tissue expression pattern, and copy number variations associated with residual feed intake
Mitogen-activated protein kinase kinase kinase 5 (MAP3K5) is essential for apoptosis, proliferation, differentiation, and immune responses, and is a candidate marker for residual feed intake (RFI) in pig. We cloned the full-length cDNA sequence of porcine MAP3K5 by rapid-amplification of cDNA ends. The 5451-bp gene contains a 5'-untranslated region (UTR) (718 bp), a coding region (3738 bp), and.. Read More»
Genet. Mol. Res. 15(3): gmr.15037998
DOI: 10.4238/gmr.15037998
Key pathways involved in prostate cancer based on gene set enrichment analysis and meta analysis
Prostate cancer is one of the most common male malignant neoplasms; however, its causes are not completely understood. A few recent studies have used gene expression profiling of prostate cancer to identify differentially expressed genes and possible relevant pathways. However, few studies have examined the genetic mechanics of prostate cancer at the pathway level t.. Read More»
Genet. Mol. Res. 10(4): 2011.December.14.10
DOI: 10.4238/2011.December.14.10
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