J. Liu

Association of interleukin-6 gene polymorphisms and circulating levels with keloid scars in a Chinese Han population

• X.J. Zhu
• W.Z. Li
• H. Li
• C.Q. Fu
• J. Liu

The aim of the present study is to explore the effect of IL-6 gene polymorphisms on the development of keloid scar (KS) in the Chinese Han population. Genotyping of IL-6 was performed by the polymerase chain reaction (PCR), followed by restriction fragment length polymorphism assays (PCR-RFLP). Serum level of IL-6 was measured using enzyme-linked immunosorbent assay.. Read More»

Genet. Mol. Res. 16(2):

Association of tumor necrosis factor-�± gene polymorphism with osteoarticular tuberculosis prognosis in a Hebei population

Y.J. Lv, S.J. Liu, W.N. Hu, G.P. Zhang, Q.Y. Ren, L.D. Zheng, Y.C. Zhang, R.Q. Li and Z.K. Zhang

This study investigated the association of tumor necrosis factor-α (TNF-α)-308, -238, and -863 polymorphisms with osteoarticular tuberculosis (OA-TB) prognosis in a Hebei population. Genomic DNA was extracted from venous blood samples of 120 OA-TB patients and 100 healthy volunteers. TNF-α-308, -238, and -863 were analyzed by PCR-restriction fragme.. Read More»

Genet. Mol. Res. 15(4): gmr15048937

DOI: 10.4238/gmr15048937

Genetic characteristics of non-Hodgkin lymphoma in ethnic Uighur people, and their clinical significance

L. Xu, X.G. Zou, X. Wang, A.B.L.M.T. Hairesa and J.J. Liu

The incidence of non-Hodgkin lymphoma (NHL) in China is increasing and is attracting attention as a topic of research. The percentage of NHL cases in ethnic Uighur people is also gradually increasing. We therefore recruited Uighur people with NHL to investigate the correlation between genetic alternations and clinical/pathological features in an attempt to determine.. Read More»

Genet. Mol. Res. 15(4): gmr15048960

DOI: 10.4238/gmr15048960

Whole-transcriptome sequencing of Pinellia ternata using the Illumina platform

X. Huang, Y. Jing, D.J. Liu, B.Y. Yang, H. Chen and M. Li

Pinelliae rhizoma is the dried tuber of Pinellia ternata (Thunb.) Breit., and has been used for thousands of years as a traditional Chinese medicine. However, its genomic background is little known. With the development of high-throughput genomic sequencing, it is now easy and cheap to obtain genomic information. In this study, 193,032,910 high-quality clean reads w.. Read More»

Genet. Mol. Res. 15(2): gmr.15028062

DOI: 10.4238/gmr.15028062

Genome-wide identification, phylogenetic relationships, and expression analysis of the carotenoid cleavage oxygenase gene family in pepper

X.H. Zhang, H.Q. Liu, Q.W. Guo, C.F. Zheng, C.S. Li, X.M. Xiang, D.F. Zhao, J. Liu, J. Luo, D.K. Zhao, J.Q. Zheng and H.J. Wan

Carotenoid cleavage oxygenases (CCOs) are a family of dioxygenases, which specifically catalyze the cleavage of conjugated double bonds in carotenoids and apocarotenoids in plants. In this study, genome-wide analysis of CCO genes in pepper plants was performed using bioinformatic methods. At least 11 members of the CCO gene family were identified in the pepper genom.. Read More»

Genet. Mol. Res. 15(4): gmr.15048695

DOI: 10.4238/gmr.15048695

Multifocal central nervous system hemangioblastoma: a case report and review of the literature

L.Z. Chu, Z.Z. Guan, J. Liu, H. Yang, X.L. Qi, M.G. Dong, Y.M. Chen, Y.N. Xiang and Y. Li

An effective therapy for multifocal central nervous system hemangioblastoma (CNS HB) is needed. Here, we report a case of multifocal CNS HB. A 43-year-old man was diagnosed with CNS HB by enhanced computed tomography and magnetic resonance imaging. Six solid tumors and one cystic nodule were detected in his cerebellum. The patient underwent three surgeries followed .. Read More»

Genet. Mol. Res. 13(3): 2014.September.29.3

DOI: 10.4238/2014.September.29.3

Comparison of EGFR mutation rates in lung adenocarcinoma tissue and pleural effusion samples

Y. Guan, Z.J. Wang, L.Q. Wang, D.F. Hua and J. Liu

The goal of the current study was to investigate the differences in epidermal growth factor receptor (EGFR) mutation rates in tumor tissue and pleural effusion specimens from patients with lung adenocarcinoma. PCR amplification and gene sequencing were used to detect EGFR mutations in exons 18, 19, 20, and 21 in tumor tissue and pleural effusion samples from 50 pati.. Read More»

Genet. Mol. Res. 15(2): gmr.15027001

DOI: 10.4238/gmr.15027001

Promoter methylation and histone modifications affect the expression of the exogenous DsRed gene in transgenic goats

M.T. Nuo, J.L. Yuan, W.L. Yang, X.Y. Gao, N. He, H. Liang, M. Cang and D.J. Liu

Transgene silencing, which is common in transgenic plants and animals, limits the generation and application of genetically modified organisms, and is associated with the exogenous gene copy number, the methylation status of its promoters, and histone modification abnormalities. Here, we analyzed the expression of the exogenous gene DsRed and the methylation status .. Read More»

Genet. Mol. Res. 15(3): gmr.15038560

DOI: 10.4238/gmr.15038560

Reason and treatment of failure of proximal femoral nail antirotation internal fixation for femoral intertrochanteric fractures of senile patients

J.J. Liu, L.C. Shan, B.Y. Deng, J.G. Wang, W. Zhu and Z.D. Cai

The cause of postoperative failure after the treatment of femoral intertrochanteric fracture with proximal femoral nail antirotation (PFNA) was analyzed, and the reoperative methods were examined. Nine failures of 308 femoral intertrochanteric fracture patients with PFNA were treated with femoral prosthesis total hip replacement (THR) and reoperative internal fixati.. Read More»

Genet. Mol. Res. 13(3): 2014.August.7.10

DOI: 10.4238/2014.August.7.10

Identifying differentially expressed genes and pathways in two types of non-small cell lung cancer: adenocarcinoma and squamous cell carcinoma

J. Liu, X.Y. Yang and W.J. Shi

Non-small cell lung carcinoma, NSCLC, accounts for 80-85% of lung cancers. NSCLC can be mainly divided into two types: adenocarcinoma (ADC) and squamous cell carcinoma (SCC). The purpose of our study was to identify and differentiate the pathogenesis of ADC and SCC at the molecular level. The gene expression profiles of ADC and SCC were downloaded from Gene Expressi.. Read More»

Genet. Mol. Res. 13(1): 2014.January.8.8

DOI: 10.4238/2014.January.8.8