J. Zhang
Pharmacogenetics-based warfarin dose prediction algorithm for patients with heart valve replacement in Southeast China
This study was designed to analyze the influence of polymorphisms in CYP2C9, VKORC1, CYP4F2, GGCX, and EPHX1 genes on the optimal warfarin dosage in patients who have undergone artificial heart valve replacement and establish an algorithm for use by physicians in Southeast China to predict each patient’s optimal steady-state warfarin dose. One-hundred and nine.. Read More»
Genet. Mol. Res. 16(3): gmr16038881
DOI: 10.4238/gmr16038881
Rapid development of polymorphic microsatellite markers for the Amur sturgeon (Acipenser schrenckii) using next-generation sequencing technology
Anthropogenic activities have seriously impacted wild resources of the Amur sturgeon, Acipenser schrenckii, and more information on local and regional population genetic structure is required to aid the conservation of this species. In this study, we report the development of 12 novel polymorphic microsatellite loci using next-generation sequencing technology, and the genotyping of 24 individua.. Read More»
Genet. Mol. Res. 14(3): 2015.July.14.16
DOI: 10.4238/2015.July.14.16
Gynophore miRNA analysis at different developmental stages in Arachis duranensis
Peanut is one of the most important oilseed crops in the world that provides a significant amount of lipids and protein for many people. The gynophore plays an important role in gynophore development after fertilization of the peanut ovule. MicroRNAs (miRNAs) play an important role in numerous developmental and physiological plant processes. Therefore, it is essenti.. Read More»
Genet. Mol. Res. 15(4): gmr15048691
DOI: 10.4238/gmr15048691
Erlotinib enhances the CIK cell-killing sensitivity of lung adenocarcinoma A549 cells
We examined the effects and molecular mechanism of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor erlotinib on NKG2D ligand expression in human lung adenocarcinoma A549 cells and the cytotoxicity of cytokine-induced killer cells. Flow cytometry was used to detect NKG2D ligand expression in A549 cells under effects of erlotinib and EGFR downstream molecules, including LY29.. Read More»
Genet. Mol. Res. 14(2): http://dx.doi.org/2015.April.10.18
DOI: http://dx.doi.org/10.4238/2015.April.10.18
Evaluation of powdery mildew-resistance of grape germplasm and rapid amplified polymorphic DNA markers associated with the resistant trait in Chinese wild Vitis
The resistance of wild Vitis germplasm, including Chinese and American wild Vitis and Vitis vinifera cultivars, to powdery mildew (Uncinula necator Burr.) was evaluated for two consecutive years under natural conditions. Most of the Chinese and North American species displayed a resistant phenotype, whereas all of the European species were highly susceptible. The Al.. Read More»
Genet. Mol. Res. 13(2): http://dx.doi.org/2014.May.9.3
DOI: http://dx.doi.org/10.4238/2014.May.9.3
Expression and clinical significance of ADAM17 protein in esophageal squamous cell carcinoma
We examined disintegrin and metalloproteinase 17 (ADAM17) protein expression in esophageal squamous cell carcinoma and its clinical and pathological correlated factors. Western blotting and immunohistochemistry were used to detect ADAM17 protein expression in esophageal squamous cell carcinoma and the corresponding normal esophageal mucosa in 50 cases. ADAM17 protein expression in 50 cases with.. Read More»
Genet. Mol. Res. 14(2): 2015.April.30.12
DOI: 10.4238/2015.April.30.12
Association between ADSL, GARS-AIRS-GART, DGAT1, and DECR1 expression levels and pork meat quality traits
In this study, meat quality traits were compared between Chinese lard- and European lean-type pigs. The association between expression of four genes (ADSL, GARS-AIRS-GART, DGAT1, and DECR1) and meat quality traits was also investigated. Meat quality traits were found to differ significantly between pig breeds. Meat color parameter values (a* and b*.. Read More»
Genet. Mol. Res. 14(4): 2015.November.18.47
DOI: 10.4238/2015.November.18.47
Multidrug resistance gene and its relationship to ulcerative colitis and immune status of ulcerative colitis
We examined the relationship among the multidrug resistance (MDR1) gene product P-glycoprotein (P-gp), ulcerative colitis, and immune status under ulcerative colitis. MDR1 P-gp expression and interleukin-8 levels in ulcerative colitis were determined using immunohistochemistry and a double-antibody sandwich avidin-biotin complex-enzyme-linked immunosorbent assay, respectively. Nitric oxide cont.. Read More»
Genet. Mol. Res. 13(4): 2014.December.19.5
DOI: 10.4238/2014.December.19.5
Molecular diversity and population structure of the forage grass Hemarthria compressa (Poaceae) in south China based on SRAP markers
Hemarthria compressa is one of the most important and widely utilized forage crops in south China, owing to its high forage yield and capability of adaptation to hot and humid conditions. We examined the population structure and genetic variation within and among 12 populations of H. compressa in south China using sequence-related amplified polymorphism (SRAP) markers. High genetic diversity wa.. Read More»
Genet. Mol. Res. 11(3): 2012.May.24.3
DOI: 10.4238/2012.May.24.3
Association between dietary intake of folate and MTHFR and MTR genotype with risk of breast cancer
We investigated the association between dietary intake of folate, vitamin B6, and the 5,10-methylenetetrahydrofolate reductase (MTHFR) genotype with breast cancer. A matched case-control study was conducted, and 413 patients with newly diagnosed and histologically confirmed breast cancer and 436 controls were recruited. Folate intake, vitamin B6, and vitamin B12 levels were calculated, and the .. Read More»
Genet. Mol. Res. 13(4):
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