J.B. Liu

Publications of : J.B. Liu

Human Genetics Research Article

MiR-200c inhibits metastasis of breast tumor via the downregulation of Foxf2

The forkhead box F2 (Foxf2) gene suppresses epithelial-mesenchymal transition via the modulation of transcription of zinc finger E-box-binding homeobox 1 (Zeb1) and epithelial (E)-cadherin, thereby inhibiting tumor metastasis. Additionally, the specific binding of microRNA (miR)-200c to Foxf2 mRNA impedes metastatic pulmonary cancer. However, the role of miR-200c in.. Read More»

Genet. Mol. Res. 16(3): gmr16038971

DOI: 10.4238/gmr16038971

Human Genetics Research Article

Multivariate analysis of molecular markers in peripheral blood associated with recurrence and metastasis of hepatocellular carcinoma

X.J. Liu, B. Wang, W.G. Jiang, Y.J. Li, J.B. Liu and M. Zhang

Invasion, metastasis, and recurrence are the most common causes of death in patients with hepatocellular carcinoma (HCC) and are therefore critical factors for both therapy and prognosis. Current methods for diagnosis of HCC rely mainly on serological markers such as alpha-fetoprotein and liver enzymes, together with physical assessment and imaging techniques. The availability of more accurate .. Read More»

Genet. Mol. Res. 14(1): 2015.February.20.5

DOI: 10.4238/2015.February.20.5

Animal Genetics Research Article

De novo assembly and characterization of skin transcriptome using RNAseq in sheep (Ovis aries)

Y.J. Yue, J.B. Liu, M. Yang, J.L. Han, T.T. Guo, J. Guo, R.L. Feng and B.H. Yang

Wool is produced via synthetic processes of wool follicles, which are embedded in the skin of sheep. The development of new-generation sequencing and RNA sequencing provides new approaches that may elucidate the molecular regulation mechanism of wool follicle development and facilitate enhanced selection for wool traits through gene-assisted selection or targeted gene manipulation. We performed.. Read More»

Genet. Mol. Res. 14(1): 2015.February.13.16

DOI: 10.4238/2015.February.13.16

Animal Genetics Research Article

Analysis of agouti signaling protein (ASIP) gene polymorphisms and association with coat color in Tibetan sheep (Ovis aries)

J.L. Han, M. Yang, Y.J. Yue, T.T. Guo, J.B. Liu, C.E. Niu and B.H. Yang

Tibetan sheep, an indigenous breed, have a wide variety of phenotypes and a colorful coat, which make this breed an interesting model for evaluating the effects of coat-color gene mutations on this phenotypic trait. The agouti signaling protein (ASIP) gene is a positional candidate gene, as was inferred based on previous study. In our research, ASIP gene copy numbers in genomic DNA were detecte.. Read More»

Genet. Mol. Res. 14(1): 2015.February.6.22

DOI: 10.4238/2015.February.6.22

Animal Genetics Research Article

Limitation of high-resolution melting curve analysis for genotyping simple sequence repeats in sheep

M. Yang, Y.J. Yue, T.T. Guo, J.L. Han, J.B. Liu, J. Guo, X.P. Sun, R.L. Feng, Y.Y. Wu, C.F. Wang, L.P. Wang and B.H. Yang

Variation in microsatellite or simple sequence repeat (SSR) loci has, until recently, relied heavily on the use of gel-based methods that can be both time consuming and difficult to genotype. Non gel-based systems are therefore important to increase simplicity and improve turn-around time without compromising assay sensitivity and accuracy. In this report, we assess.. Read More»

Genet. Mol. Res. 13(2): 2014.April.8.7

DOI: 10.4238/2014.April.8.7

Animal Genetics Research Article

Analysis of geographic and pairwise distances among sheep populations

J.B. Liu, Y.J. Yue, X. Lang, F. Wang, X. Zha, J. Guo, R.L. Feng, T.T. Guo, B.H. Yang and X.P. Sun

This study investigated geographic and pairwise distances among seven Chinese local and four introduced sheep populations via analysis of 26 microsatellite DNA markers. Genetic polymorphism was rich, and the following was discovered: 348 alleles in total were detected, the average allele number was 13.38, the polymorphism information content (PIC) of loci ranged fro.. Read More»

Genet. Mol. Res. 13(2): http://dx.doi.org/2014.June.9.4

DOI: http://dx.doi.org/10.4238/2014.June.9.4