K.S.F. e Silva
Infertility caused by an association between Arg72Pro polymorphism of the p53 gene and Glu298Asp of the eNOS gene in patients with endometriosis
Endometriosis is characterized by ectopic endometrial tissue and affects millions of women worldwide. The disease leads to various symptoms such as chronic pelvic pain and infertility and does not yet have a well-defined etiology. The pathology is similar to cancer, since endometrial cells are highly proliferative, invade tissues and may be associated with tumor sup.. Read More»
Genet. Mol. Res. 17(3): http://dx.doi.org/gmr18046
DOI: http://dx.doi.org/10.4238/gmr18046
Polymorphisms of GSTM1, GSTT1, and p53 in Goi�?¢nia, Goi�?¡s
Genetic polymorphisms are defined as changes within the DNA sequences of genes that have frequencies in the population higher than 1%. The glutathione S-transferases play an important role in the cellular detoxification systems involved in oxidative stress that can lead to accumulation of reactive oxygen species. Epidemiological studies have suggested that individuals with homozygous deletion o.. Read More»
Genet. Mol. Res. 14(4): 2015.December.21.4
DOI: 10.4238/2015.December.21.4
Pterygium in patients from Goi�?¢nia, Goi�?¡s, Brazi
Pterygium is an inflammatory and degenerative ocular surface disease in which the conjunctiva on the cornea grows to form a fibrous tissue in the shape of a triangle. The disorder may be characterized by cell proliferation, inflammatory processes, fibrosis, angiogenesis, and destruction of the extracellular matrix. The anomaly is considered a degenerative eye disease and is erroneously confused.. Read More»
Genet. Mol. Res. 14(2): 2015.June.9.4
DOI: 10.4238/2015.June.9.4
Analysis of the GSTM1-null polymorphism in patients with pterygium from Goi�?¢nia, Goi�?¡s Brazil
The first reports about pterygium date back to Hippocrates, and this disease still threatens vision health around the world. Pterygium is a formation of fibrous tissue consisting of highly vascularized epithelial and subepithelial tissue that grows excessively and with an abnormal shape on the cornea. Many physical and biological factors are associated with the pathogenesis of pterygium, includ.. Read More»
Genet. Mol. Res. 14(2): 2015.June.9.3
DOI: 10.4238/2015.June.9.3
Analysis of the prevalence of polymorphisms in the glutathione S transferase gene (GST) in cataract patients from Goi�?¢nia
The aim of this study was to determine the prevalence of polymorphisms in the glutathione S-transferase genes GSTM1 and GSTT1 in patients with lens opacity (cataract). Peripheral blood samples were obtained from male and female patients (N = 23) with cataract. The GSTM1 and GSTT1 polymorphic regions were amplified by polymerase chain reaction, and the amplification products were electrophoresed.. Read More»
Genet. Mol. Res. 15(3): gmr.15038050
DOI: 10.4238/gmr.15038050
Male idiopathic infertility and the TP53 polymorphism in codon 72
Many environmental agents affect the development of male germ cells at different stages. Apoptosis is common during normal spermatogenesis; it plays an important role in controlling the number of germ cells and the disposal of defective stem cells to produce functional sperm. The presence of p53 in primary spermatocytes suggests that it plays a role in the prophase .. Read More»
Genet. Mol. Res. 15(4): gmr15048882
DOI: 10.4238/gmr15048882
GSTM1 polymorphism in patients with clinical manifestations of atherosclerosis
Atherosclerosis is characterized by lesions, called atheroma or atheromatous plaques, in the inner layer of blood vessels, which block the vascular lumen and weaken the underlying tunica media. Several modifiable and non-modifiable risk factors for the development of atherosclerosis exist. The modifiable risk factors include hypertension, smoking, obesity, high LDL .. Read More»
Genet. Mol. Res. 16(1): gmr16019101
DOI: 10.4238/gmr16019101
Polymorphisms of GSTM1 and GSTT1 genes in symptomatic atherosclerotic patients with hypertension and/or type 2 diabetes mellitus
Atherosclerosis is a chronic inflammatory condition and originates due to the accumulation of lipids in the innermost layer of the arteries. It is often related due to other underlying diseases, such as systemic arterial hypertension and type 2 diabetes mellitus, which may be the cause or may contribute to a worse prognosis of atherosclerosis. Such diseases also hav.. Read More»
Genet. Mol. Res. 16(4): gmr16039836
DOI: 10.4238/gmr16039836
Polymorphism of the gene eNOS G894T (Glu298Asp) in symptomatic patients with aterosclerosis
Atherosclerotic and its cardiovascular complications are responsible for 17.5 million deaths a year, according to the World Health Organization. There is consensus that atherosclerosis involves multiple pathogenic processes initiated by endothelial dysfunction, with inflammation and vascular proliferation determining alterations in the matrix, with consequent format.. Read More»
Genet. Mol. Res. 16(2): gmr16029550
DOI: 10.4238/gmr16029550
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