K.S.F. Silva
Atherosclerosis: analysis of the eNOS (T786C) gene polymorphism
The coronary arteriosclerotic disease is the most common cardiovascular disease. Atherosclerosis affects large- and medium-sized arteries leading to severe thrombosis or artery stenosis that could evolve to myocardial infarction, ischemic stroke, ischemic injury of kidneys and intestines, and several other life-threatening clinical manifestations. Nitric oxide has b.. Read More»
Genet. Mol. Res. 16(3): gmr16039708
DOI: 10.4238/gmr16039708
Genetic polymorphisms in patients with endometriosis: an analytical study in Goi�¢nia (Central West of Brazil)
In healthy women, intra- and extracellular controls prevent the attachment and proliferation of ectopic endometrial cells. During endometriosis, abnormalities in these control mechanisms permit the survival of endometrial cells, their subsequent attachment to the peritoneal cavity, and disease progression. These abnormal cells cause invasion of tissues and induce an.. Read More»
Genet. Mol. Res. 15(2): gmr.15028135
DOI: 10.4238/gmr.15028135
Association between primary open angle glaucoma and genetic polymorphisms GSTM1/GSTT1 in patients from Goi�¢nia Central-West Region of Brazil
In this study, we evaluated the genotype profile of GSTM1 and GSTT1 polymorphisms in patient carriers of primary open-angle glaucoma in the population of Goiânia, GO, Brazil. This case-control study included 100 Brazilian patients with glaucoma and 53 patients without glaucoma. Blood samples were genotyped for polymorphisms in GST genes using polymerase chain reaction-based methods. Polym.. Read More»
Genet. Mol. Res. 13(4):
Characterization of molecular hemoglobin c and beta thalassemia
The hemoglobinopathies are a group of hereditary alterations prevalent in many parts of the world, but significantly affect the Brazilian population for its abundant miscegenation. These alterations in structural genes that cause the formation of hemoglobin variants, and/or regulatory genes, causing thalassemias. Currently, the number of identified abnormal hemoglob.. Read More»
Genet. Mol. Res. 16(4): gmr16039851
DOI: 10.4238/gmr16039851
Analysis of p53 gene polymorphism (codon 72) in symptomatic patients with atherosclerosis
Atherosclerosis is a multifactorial pathological disease that alters the morphology and function of arterial walls. The atheroma growth leads to vessel hardening and lumen narrowing, limiting the blood flow. The atheroma plaque can eventually break, expose highly thrombogenic material and lead to platelet activation and subsequent formation of a thrombus that may bl.. Read More»
Genet. Mol. Res. 16(3): gmr16039721
DOI: 10.4238/gmr16039721
Molecular analysis of the GSTT1 gene polymorphism in patients with clinical manifestation of atherosclerosis
Atherosclerosis is a chronic inflammatory disease formed by the accumulation of lipids in the innermost layer and large-caliber artery (tunica intima). This accumulation, along with platelet factors, stimulates the proliferation of muscle cells in this region. Over than 400 genes may be related to the pathology since they regulate endothelial function, coagulation, .. Read More»
Genet. Mol. Res. 16(3): gmr16039620
DOI: 10.4238/gmr16039620
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