L. Zhang
Polymorphisms of AluI and Hin1I loci of the IGF-1R gene and their genetic effects on growth traits in Bian chickens
Growth traits are important economic traits in broiler chicken production. AluI and Hin1I loci are two restriction sites, which are respectively located in exons 2 and 3 of the IGF-1R gene. These two loci are significantly related to the growth traits in Jinghai Yellow chickens. In this study, a correlation analysis was performed between these two loci and the growt.. Read More»
Genet. Mol. Res. 16(2): gmr16029619
DOI: 10.4238/gmr16029619
MicroRNA-122 is involved in oxidative stress in isoniazid-induced liver injury in mice
Many studies have shown that the pathogenesis of liver injury includes oxidative stress. MicroRNA-122 may be a marker for the early diagnosis of drug-induced liver injury. However, the relationship between microRNA-122 and oxidative stress in anti-tuberculosis drug-induced liver injury remains unknown. We measured changes in tissue microRNA-122 levels and indices of oxidative stress during live.. Read More»
Genet. Mol. Res. 14(4): 2015.October.26.22
DOI: 10.4238/2015.October.26.22
Correlation between methylation of the E-Cadherin gene and malignancy of prostate cancer
Prostate cancer is a common malignant tumor in males with an unclear pathogenic mechanism. As one epigenetic regulation mechanism, DNA methylation of the whole genome and specific gene(s) plays critical roles in pathogenesis, progression, diagnosis, and treatment of prostate cancer. The E-Cadherin gene is involved in cell metabolism and has been suggested to be rela.. Read More»
Genet. Mol. Res. 15(2): gmr.15028046
DOI: 10.4238/gmr.15028046
Prognostic and assessment value of hyperglycemia and glycosylated hemoglobin in critical patients
Hyperglycemia is common in critical patients and high blood glucose levels have a negative effect on their prognosis. The aim of this study was to investigate the effect of hyperglycemia and glycosylated hemoglobin (GHb) in critical patients. A total of 648 critical patients were enrolled in the study and received a random blood glucose test when they entered the em.. Read More»
Genet. Mol. Res. 13(3): 2014.January.24.8
DOI: 10.4238/2014.January.24.8
Molecular cloning and immune response analysis of putative variable lipoproteins from Mycoplasma mycoides subsp capri
Mycoplasma mycoides subsp capri is the cause of goat “MAKePS” (Mastitis, Arthritis, Keratoconjunctivitis, Pneumonia, Septicemia) syndrome. We identified three genes (GL_ 000459; 000461; 000462) as variable lipoprotein genes in the M. mycoides subsp capri str. PG3 genome by genomic information and comparative genomic analyses. To study the role of variabl.. Read More»
Genet. Mol. Res. 13(1): http://dx.doi.org/2014.March.12.5
DOI: http://dx.doi.org/10.4238/2014.March.12.5
Ovine prion protein genotype frequencies in northwestern China
Anti-scrapie breeding programs have been initiated to screen for scrapie-resistant sheep based on ovine prion protein gene (PRNP) genotypes at codons 136, 154 and 171 in many countries, especially European Union member states. However, investigation of sheep PRNP genotypes is limited in China, despite the large number of sheep breeds. We analyzed 432 sheep of five d.. Read More»
Genet. Mol. Res. 11(2): dx.doi.org/2012.June.21.2
DOI: dx.doi.org/10.4238/2012.June.21.2
Cloning and expression analysis of PpSUT2 encoding a sucrose transporter in pear
A 1794-bp cDNA fragment was amplified from mRNA isolated from pear (Pyrus pyrifolia NaKai. Cuiguan) leaves by using primers based on the sequences generated during the analysis of the pear transcriptome. The 597-amino acid sequence encoded by the cDNA was compared with the sequences in GenBank, and it was found to be similar to that of members of the sucrose-proton co-transporter family. The hy.. Read More»
Genet. Mol. Res. 13(4):
Analysis of genetic diversity in Larix gmelinii (Pinaceae) with RAPD and ISSR markers
Dahurian larch (Larix gmelinii), a deciduous conifer, is the northernmost tree, native to eastern Siberia and nearby regions of China. We used growth traits and molecular markers to assess genetic variation in different L. gmelinii growing regions; 105 individual samples were collected from seven regions of the Qingshan Forestry Centre, Heilongjiang Province, China. The greatest genetic regional v.. Read More»
Genet. Mol. Res. 12(1): 2013.January.24.12
DOI: 10.4238/2013.January.24.12
Mechanism of reversal of multidrug resistance by curcumin in human colorectal cancer cell line HCT-8/5-FU
Since there are no studies on the reversal of multidrug resistance by curcumin in the human colorectal cancer cell line HCT-8/5-FU, our aim was to search for highly efficient reversal agents and investigate the underlying mechanisms of this reversal. The cytotoxic effects of curcumin and 5-FU on HCT-8 and HCT-8/5-FU cells and the reversal effects of 5-FU in combinat.. Read More»
Genet. Mol. Res. 16(2): gmr16029414
DOI: 10.4238/gmr16029414
Gene expression patterns of invertase gene families and modulation of the inhibitor gene in tomato sucrose metabolism
Patterns of gene expression in the different types of sucrose metabolism in the tomato are highly variable and heritable. This genetic variation causes considerable functional differences. We examined the patterns of expression of invertase (Inv) gene families and an invertase inhibitor (INH) gene involved in elongating roots, hypocotyls, and fruit of the tomato (Lycopersicon esculentum cv. Mic.. Read More»
Genet. Mol. Res. 12(3): 2013.January.24.1
DOI: 10.4238/2013.January.24.1
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