M. Li
Improvement in orthopedic outcome score and reduction in IL-1�², CXCL13, and TNF-�± in synovial fluid of osteoarthritis patients following arthroscopic knee surgery
Knee osteoarthritis (KOA) is a common degenerative joint disease and immune system dysregulation has been implicated in its pathogenesis. The effect of arthroscopic knee surgery, an important method for KOA diagnosis and treatment, on the expression of immune regulators remains poorly understood. We aimed to investigate the clinical efficacy of such surgery and its .. Read More»
Genet. Mol. Res. 16(3): gmr16039487
DOI: 10.4238/gmr16039487
Molecular cloning and expression analysis of TRAF3 in chicken
Tumor necrosis factor receptor-associated factor 3 (TRAF3) is a crucial regulator that suppresses c-Jun N-terminal kinase and non-canonical nuclear factor-kB signaling, but facilitates type I interferon production. To determine TRAF3 function in innate immune responses among birds, particularly chicken, we cloned and characterized the chicken TRAF3 gene (chTRAF3) and detected its tissue express.. Read More»
Genet. Mol. Res. 14(2): 2015.April.30.14
DOI: 10.4238/2015.April.30.14
Involvement of ERK1/2 signaling in proliferation of eight liver cell types during hepatic regeneration in rats
It has been well established that ERK1/2 signaling, often subdivided into nine types of pathways, can regulate the hepatocyte proliferative response during liver regeneration. However, the effect of ERK1/2 signaling on the proliferation of other hepatic cell types remains unclear. We isolated and purified 8 liver cell types at 10 time points after 2/3 hepatectomy in adult rats. For each cell ty.. Read More»
Genet. Mol. Res. 12(1): 2013.March.11.14
DOI: 10.4238/2013.March.11.14
A potential indicator of denervated muscle atrophy: the ratio of myostatin to follistatin in peripheral blood
Myostatin is a secreted negative regulator of muscle mass, and follistatin antagonizes the function of several members of the TGF-b family, including myostatin. Previously, myostatin expression was found to be closely associated with atrophy of the gastrocnemius muscle, showing a linear correlation, after sciatic nerve injury. In this study, we investigated the poss.. Read More»
Genet. Mol. Res. 10(4): 2011.October.21.7
DOI: 10.4238/2011.October.21.7
QTLs for rice flag leaf traits in doubled haploid populations in different environments
Two rice doubled haploid (DH) populations derived from the crosses of ZYQ8/JX17 and CJ06/TN1 were used to detect quantitative trait loci (QTLs) for flag leaf length (FLL), width (FLW), and angle (FLA) under long-day conditions in Hangzhou (subtropical zone) and short-day conditions in Hainan (tropical zone), China. The four parents differed significantly in all 3 traits. FLL was found to be pos.. Read More»
Genet. Mol. Res. 14(2): 2015.June.18.21
DOI: 10.4238/2015.June.18.21
Analysis of glutathione peroxidase 1 gene polymorphism and Keshan disease in Heilongjiang Province, China
Keshan disease (KD) is an endemic cardiomyopathy associated with selenium deficiency. Recent studies indicate that glutathione peroxidase 1 (GPx1) mutation decreases GPx activity in myocardial cells and increases the risk of KD. To further clarify the correlation between GPx1 polymorphism and KD, we analyzed GPx1 polymorphism, blood selenium levels and GPx activity .. Read More»
Genet. Mol. Res. 10(4):
Polymorphic microsatellite loci developed from the Hong Kong oyster (Crassostrea hongkongensis)
Forty polymorphic microsatellite loci were developed from Crassostrea hongkongensis using an enriched partial genomic library with magnetic beads. The polymorphism of these loci was assessed in 30 individuals from a wild population. The allele number of the polymorphic markers ranged from 2 to 13, with an average of 5.8 per locus. The polymorphism information conten.. Read More»
Genet. Mol. Res. 15(4): gmr.15048676
DOI: 10.4238/gmr.15048676
Differential expression of dormancy-Associated genes in fastigiata and hypogaea peanut
Seed dormancy is a temporary replacement state observed in some higher plants, which prevents germination under unfavorable conditions. In several species, dormancy process is triggered by hormonal factors, initiated by ABA and precursor enzymes. In this work, we investigated the relationship between dormancy and the expression of ARP, DMR1, and NCED genes in uprigh.. Read More»
Genet. Mol. Res. 16(4): gmr16039820
DOI: 10.4238/gmr16039820
Whole-transcriptome sequencing of Pinellia ternata using the Illumina platform
Pinelliae rhizoma is the dried tuber of Pinellia ternata (Thunb.) Breit., and has been used for thousands of years as a traditional Chinese medicine. However, its genomic background is little known. With the development of high-throughput genomic sequencing, it is now easy and cheap to obtain genomic information. In this study, 193,032,910 high-quality clean reads w.. Read More»
Genet. Mol. Res. 15(2): gmr.15028062
DOI: 10.4238/gmr.15028062
Rapid development of polymorphic microsatellite markers for the Amur sturgeon (Acipenser schrenckii) using next-generation sequencing technology
Anthropogenic activities have seriously impacted wild resources of the Amur sturgeon, Acipenser schrenckii, and more information on local and regional population genetic structure is required to aid the conservation of this species. In this study, we report the development of 12 novel polymorphic microsatellite loci using next-generation sequencing technology, and the genotyping of 24 individua.. Read More»
Genet. Mol. Res. 14(3): 2015.July.14.16
DOI: 10.4238/2015.July.14.16
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