M.A. Ali
Generic relationships among Molluginaceae inferred from a molecular phylogenetic analysis of the matK gene
The family Molluginaceae (order Caryophyllales) is considered polyphyletic based on the photosynthetic pathway, C4 evolution, and phylogeny of the family. This inference was made based on photosynthetic, anatomical, and molecular datasets. The generic circumscription of this family has greatly been changed owing to the placement of several of its genera into the Car.. Read More»
Genet. Mol. Res. 16(2): gmr16029295
DOI: 10.4238/gmr16029295
Molecular docking of the anticancer bioactive compound proceraside with macromolecules involved in the cell cycle and DNA replication
The bioactive compounds proceraside A, frugoside and calotropin, which were extracted from the root bark of Calotropis procera (Aiton) W.T. Aiton (family Asclepiadaceae), were recently reported to inhibit the growth of inhibition against various human cancer cell lines in vitro. However, their modes of action have not been clearly defined. Therefore, we attempted an.. Read More»
Genet. Mol. Res. 15(2): gmr.15027829
DOI: 10.4238/gmr.15027829
Delimiting invasive Myriophyllum aquaticum in Kashmir Himalaya using a molecular phylogenetic approach
Myriophyllum aquaticum (Vell.) Verdc. (family Haloragaceae) is one of the most invasive and destructive South American aquatic plant species and is present in a wide range of geographic regions, including the Kashmir Himalaya. Confusion regarding the taxonomic delimitation of M. aquaticum in the Himalayan region impedes effective and targeted management. Hence, our goal was im.. Read More»
Genet. Mol. Res. 13(3): 2014.September.12.233539
DOI: 10.4238/2014.September.12.233539
Target fishing of glycopentalone using integrated inverse docking and reverse pharmacophore mapping approach
Glycopentalone isolated from Glycosmis pentaphylla (family Rutaceae) has cytotoxic and apoptosis inducing effects in various human cancer cell lines; however, its mode of action is notknown. Therefore, target fishing of glycopentalone using a combined approach of inverse docking and reverse pharmacophore mapping approach was used to identify potential targets of glycopentalone, and gain insight.. Read More»
Genet. Mol. Res. 15(3): gmr.15038544
DOI: 10.4238/gmr.15038544
Unraveling systematic inventory of Echinops (Asteraceae) with special reference to nrDNA ITS sequence-based molecular typing of Echinops abuzinadianus
The present study explored the systematic inventory of Echinops L. (Asteraceae) of Saudi Arabia, with special reference to the molecular typing of Echinops abuzinadianus Chaudhary, an endemic species to Saudi Arabia, based on the internal transcribed spacer (ITS) sequences (ITS1-5.8S-ITS2) of nuclear ribosomal DNA. A sequence similarity search using BLAST and a phyl.. Read More»
Genet. Mol. Res. 14(4): 2015.October.2.9
DOI: 10.4238/2015.October.2.9
Molecular authentication of the medicinal herb Ruta graveolens (Rutaceae) and an adulterant using nuclear and chloroplast DNA markers
Dried parts of different plant species often look alike, especially in powdered form, making them very difficult to identify. Ruta graveolens, sold as a dried medicinal herb, can be adulterated with Euphorbia dracunculoides. The genomic DNA was isolated from the leaf powder (100 mg each) using the modified CTAB method. Internal transcribed spacer sequences of nuclea.. Read More»
Genet. Mol. Res. 10(4): 2011.November.10.3
DOI: 10.4238/2011.November.10.3
Interactome analysis and design of inhibitors against selected protein targets of Ser/Thr protein kinase (STPK) signaling pathways in Mycobacterium tuberculosis H37Rv
Tuberculosis continues to be a major cause of mortality worldwide despite significant advances in chemotherapy and development of the BCG vaccine. Although curable, the tuberculosis treatment period (6-9 months) presents many concerns, including patient noncompliance and the development of drug toxicity and drug resistance. This study aimed to understand the protein-protein interactions of key .. Read More»
Genet. Mol. Res. 14(3): http://dx.doi.org/2015.September.1.6
DOI: http://dx.doi.org/10.4238/2015.September.1.6
Molecular phylogenetic study of Cardamine amaraeformis Nakai using nuclear and chloroplast DNA markers
The internal transcribed spacer regions of nuclear ribosomal DNA, trnL and trnL-F chloroplast genes of Cardamine amaraeformis Nakai (Brassicaceae) were sequenced and analyzed with the sequences of related Cardamine sp available in GenBank to detect the pattern of C. amaraeformis evolutionary differentiation. C. amaraeformis, which is endemic to South Korea, formed a clade with Cardamine pedata (69.. Read More»
Genet. Mol. Res. 11(3): 2012.August.31.6
DOI: 10.4238/2012.August.31.6
Molecular phylogenetic relationships among members of the family Phytolaccaceae sensu lato inferred from internal transcribed spacer sequences of nuclear ribosomal DNA
The phylogeny of a phylogenetically poorly known family, Phytolaccaceae sensu lato (s.l.), was constructed for resolving conflicts concerning taxonomic delimitations. Cladistic analyses were made based on 44 sequences of the internal transcribed spacer of nuclear ribosomal DNA from 11 families (Aizoaceae, Basellaceae, Didiereaceae, Molluginaceae, Nyctaginaceae, Phytolaccaceae s.l., Polygonaceae.. Read More»
Genet. Mol. Res. 12(4): 2013.February.28.15
DOI: 10.4238/2013.February.28.15
In vitro cytotoxicity screening of wild plant extracts from Saudi Arabia on human breast adenocarcinoma cells
This study investigated the in vitro anticancer activities of a total of 14 wild angiosperms collected in Saudi Arabia. The cytotoxic activity of each extract was assessed against human breast adenocarcinoma (MCF-7) cell lines by using the MTT assay. Among the plants screened, the potential cytotoxic activity exhibited by the extract of Lavandula dentata (Lamiaceae).. Read More»
Genet. Mol. Res. 13(2): http://dx.doi.org/2014.May.23.9
DOI: http://dx.doi.org/10.4238/2014.May.23.9
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