M.P. Gallegos-Arreola
Clinical features of Mexican patients with Mucopolysaccharidosis type I
Mucopolysaccharidosis type I (MPS-I) is an autosomal recessive lysosomal storage disorder caused by a deficiency or absence of α-l-iduronidase, which is involved in the catabolism of glycosaminoglycans (GAGs). This deficiency leads to the accumulation of GAGs in several organs. Given the wide spectrum of the disease, MPS-I has historically been classified into.. Read More»
Genet. Mol. Res. 16(3): gmr16032602
DOI: 10.4238/gmr16032602
Association between TNF-�± -308G>A and -238G>A gene polymorphisms and TNF-�± serum levels in Mexican colorectal cancer patients
The objective of this study was to examine the association between TNF-α serum levels and -308G>A and -238G>A polymorphisms in the corresponding gene by comparing healthy subjects to colorectal cancer (CRC) patients from a Mexican population. Serum levels of TNF-α were found to significantly differ between CRC patients and controls (P = 0.001), but.. Read More»
Genet. Mol. Res. 15(2): gmr.15028199
DOI: 10.4238/gmr.15028199
Association of the C677T polymorphism in the methylenetetrahydrofolate reductase gene with breast cancer in a Mexican population
The methylenetetrahydrofolate reductase (MTHFR) gene plays an important role in the steps involved in the processing of amino acids. The analysis of polymorphisms in the MTHFR gene has revealed associations with cancer; in particular the C677T polymorphism, which has been suggested to affect folate metabolism, DNA methylation, synthesis, and repair, and to contribute to tumor promotion in the m.. Read More»
Genet. Mol. Res. 14(2): http://dx.doi.org/2015.April.27.16
DOI: http://dx.doi.org/10.4238/2015.April.27.16
eNOS gene Glu298Asp and 4b/a polymorphisms are associated with renal function parameters in Mexican patients with Fabry disease
Fabry disease (FD) is an inherited X-linked lysosomal disease that causes renal failure in a high percentage of affected individuals. The eNOS gene encodes for endothelial nitric oxide synthase, which plays an important role in glomerular hemodynamics. This gene has two main polymorphisms (Glu298Asp and 4b/a) that have been studied in the context of many different d.. Read More»
Genet. Mol. Res. 15(4): gmr15047802
DOI: 10.4238/gmr15047802
Protective role of +294 T/C (rs2016520) polymorphism of PPARD in Mexican patients with colorectal cancer
PPARD encodes for peroxisome proliferator-activated receptor delta, which plays a significant role in controlling lipid metabolism, atherosclerosis, inflammation, cancer growth, progression, and apoptosis. Accumulated evidence suggests that the polymorphism rs2016520 in PPARD is associated with lipid metabolism, obesity, metabolic syndrome, and type 2 diabetes melli.. Read More»
Genet. Mol. Res. 16(1): gmr16019324
DOI: 10.4238/gmr16019324
Association of TP53 gene codon 72 polymorphism with endometriosis in Mexican women
The TP53 tumor suppressor gene plays an important role in cell cycle regulation; polymorphisms of this gene have been associated with endometriosis. We examined the role of TP53 codon 72 polymorphism by comparing genotypes of 235 healthy Mexican women (controls with surgically excluded endometriosis) with the genotypes of 151 Mexican women with endometriosis. The ob.. Read More»
Genet. Mol. Res. 11(2): 2012.May.15.10
DOI: 10.4238/2012.May.15.10
Association of the GSTM1 null polymorphism with breast cancer in a Mexican population
The glutathione S transferase (GST) family plays an important role in the processing of carcinogens. Data on the null GSTM1 genotype has revealed associations with cancer, and has been suggested to affect carcinogen metabolism and to contribute to tumor promotion inthe mammary gland. We examined the role of the null GSTM1 genotype by comparing the genotypes of 276 healthy Mexican women with tho.. Read More»
Genet. Mol. Res. 14(4): 2015.October.26.2
DOI: 10.4238/2015.October.26.2
Association of the tumor necrosis factor-alpha -308G>A polymorphism with breast cancer in Mexican women
The tumor necrosis factor-alpha (TNF-α) gene plays an important role in cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, insulin resistance, and endothelial function. Polymorphisms of TNF-α have been associated with cancer. We examined the role of the -308G>A polymorphism in this gene by comparing the genotypes of 294 healthy Mexican women with those.. Read More»
Genet. Mol. Res. 12(4): 2013.November.18.17
DOI: 10.4238/2013.November.18.17
Genetic contribution of CYP2C9, CYP2C19, and APOE variants in acenocoumarol response
Oral anticoagulants of the coumarin type have an inconveniently narrow therapeutic window, making their use difficult. In Mexico, genetic variables that participate in the heterogeneity of the therapeutic response remain poorly investigated. With the focus on warfarin, extensive pharmacogenomic studies have been performed, including those on the CYP450 family and APOE. The objective of this stu.. Read More»
Genet. Mol. Res. 12(4): 2013.October.10.7
DOI: 10.4238/2013.October.10.7
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