N. Zhao

Analysis of allopolyploidy-induced rapid genetic and epigenetic changes and their relationship in wheat

• T. Qiu
• Y.Z. Dong
• X.M. Yu
• N. Zhao
• Y.F. Yang

We used the conventional and methylation-sensitive randomly amplified polymorphic DNA (RAPD) and inter-simple sequence repeat (ISSR) analyses to assess genome-wide changes and explore the relationships between genetic and epigenetic variations among individuals of a newly synthesized allohexaploid wheat line whose genomic constitution is identical to that of the nat.. Read More»

Genet. Mol. Res. 16(2): gmr16029303

DOI: 10.4238/gmr16029303

Reduction of galectin-3 expression reduces pituitary tumor cell progression

C.X. Huang, J.N. Zhao, W.H. Zou, J.J. Li, P.C. Wang, C.H. Liu and Y.B. Wang

We investigated the role of galectin 3 in the development and progression of pituitary tumors. We used RNA interference to depress Gal-3 gene expression; MTT and flow cytometry were applied to detect changes in cell proliferation and apoptosis levels in pituitary tumor cells. Expression of apoptosis-associated genes, Bcl-2 and Baxk was analyzed by Western blot. Inhi.. Read More»

Genet. Mol. Res. 13(3): 2014.August.29.11

DOI: 10.4238/2014.August.29.11

Phosphorylation of the GluN1 subunit in dorsal horn neurons by remifentanil: a mechanism for opioid-induced hyperalgesia

C. Zhang, S.S. Li, N. Zhao and C. Yu

Remifentanil (an ultra-short acting μ-opioid receptor agonist) use has been associated with acute opioid tolerance and hyperalgesia. Previous electrophysiological studies have shown that remifentanil elicits rapid and prolonged upregulation of N-methyl-D-aspartate receptor (NMDAR) currents. However, the effect of remifentanil on the levels of the GluN1 subunit of the NMDAR in dorsal horn neu.. Read More»

Genet. Mol. Res. 14(1): 2015.March.13.13

DOI: 10.4238/2015.March.13.13

MicroRNAs as novel biomarkers for the differentiation of malignant versus benign thyroid lesions: a meta-analysis

G.J. Zhou, M. Xiao, L.N. Zhao, J.G. Tang and L. Zhang

The aim of this meta-analysis was to systematically evaluate the diagnostic accuracy of microRNAs (miRNAs) in distinguishing malignant thyroid lesions from benign ones and to determine the potential of miRNAs as diagnostic biomarkers for thyroid cancer. The random-effect model was used to summarize the pooled estimates of diagnostic accuracy, including sensitivity, specificity, positive likelih.. Read More»

Genet. Mol. Res. 14(3): 2015.July.3.3

DOI: 10.4238/2015.July.3.3

Association between B7-H1 expression and bladder cancer: a meta-analysis

Y.U. Wang, A.N.G. Liu and S.H.A.N. Zhao

B7 homolog 1 (B7-H1), which is also known as programmed death-L1, is an important member of the B7/CD28 costimulatory factor superfamily, which are emerging as important mediators of various host immune responses. B7-H1 is differentially expressed in various cell subsets and to different extents in human and murine cells. Human B7-H1 is constitutively expressed at low levels in dendritic cells .. Read More»

Genet. Mol. Res. 14(1): 2015.February.13.6

DOI: 10.4238/2015.February.13.6

Effects and mechanism of cerebroprotein hydrolysate on learning and memory ability in mice

L. An, X. Han, H. Li, Y. Ma, L. Shi, G. Xu, G. Yuan, J. Sun, N. Zhao, Y. Sheng, M. Wang and P. Du

Cerebroprotein hydrolysate is an extract from porcine brain tissue that acts on the central nervous system in various ways to protect neurons and improve memory, attention, and vigilance. This study examined the effect and mechanism of cerebroprotein hydrolysate on learning and memory in mice with scopolamine-induced impairment. Mice were given an intraperitoneal injection of scopolamine hydrob.. Read More»

Genet. Mol. Res. 15(3): gmr.15038804

DOI: 10.4238/gmr.15038804

Hypertension-mediated enhancement of JNK activation in association with endoplasmic reticulum stress in rat model hippocampus with cerebral ischemia-reperfusion

Y.N. Zhao, J.M. Li, C.X. Chen, P. Zhang and S.X. Li

Acute brain ischemia can induce the activation of c-Jun N-terminal kinases (JNKs). Hypertension is a critical etiology for brain ischemia. We identified the effects of hypertension on the activation of JNK as well as its impact on SP600125, a JNK inhibitor, during endoplasmic reticulum stress (ERS) in the hippocampus using a rat model. Transient whole-brain ischemia was induced by 4-vessel occlusi.. Read More»

Genet. Mol. Res. 14(3): http://dx.doi.org/2015.September.21.10

DOI: http://dx.doi.org/10.4238/2015.September.21.10

Role of interleukin-6 polymorphisms in the development of allergic rhinitis

N. Zhao1,2, H.J. Liu2, Y.Y. Sun3 and Y.Z. Li1

The aim of this study was to investigate the role played by the IL-6 rs1800795 (-174G/C) and rs1800796 (-572G>C) polymorphisms in the susceptibility to allergic rhinitis in a Chinese population. A total of 265 patients with allergic rhinitis and 265 controls from our hospital were enrolled in this study. The IL-6 rs1800795 and rs1800796 polymorphisms were genotyped by polymerase chain reacti.. Read More»

Genet. Mol. Res. 15(1): gmr.15016987

DOI: 10.4238/gmr.15016987

A randomized trial to compare pain control using oral analgesia with epidural analgesia after cesarean section following combined spinal-epidural anesthesia

T.D. Zhong, Q. Liu, J.N. Zhao, H.W. Wang and A. Konstantatos

This study aimed to evaluate whether combined oral oxycodone hydrochloride-controlled release tablets plus paracetamol and tramadol hydrochloride tablets are more effective than epidural analgesia for postoperative pain control and side effects after cesarean section. We randomly enrolled 60 patients scheduled for cesarean section into either: patient-controlled epi.. Read More»

Genet. Mol. Res. 13(3): 2014.March.19.4

DOI: 10.4238/2014.March.19.4

Effectiveness of bacterial infection-related cytokine profile (BIRCP) determination for monitoring pathogen infections in children with hemopathy in the bone marrow inhibition phase

X.D. Chen, B. Chen, Y.M. Tang, H. Song, S.W. Shi, S.L. Yang, W.Q. Xu, B.H. Pan, F.Y. Zhao, N. Zhao, L.Y. Zhang and J.Q. Mao

Genet. Mol. Res. 13(4):