Q. Chen

Mechanism of pingyangmycin-induced apoptosis of cultured human umbilical vein endothelial cells

• Y.D. Huang
• X. Tong
• Q. Chen
• S.W. Xia
• Y. Zhuo
• Z.H. Kang
• X.Y. Xue

In this study, we investigated the effects of pingyangmycin (PYM) on the growth inhibition and apoptosis of human umbilical vein endothelial cells (HUVEC). In this study, we aimed to explore the optimal concentration of PYM to induce the apoptosis of HUVEC and to determine its mechanism of action. After treatment of HUVEC with different concentrations of PYM for 24 .. Read More»

Genet. Mol. Res. 16(2): gmr16029298

DOI: 10.4238/gmr16029298

Genetic characterization of red-colored heartwood genotypes of Chinese fir using simple sequence repeat (SSR) markers

H.J. Duan, R.Y. Hu, B. Wu, D.X. Chen, K.Y. Huang, J. Dai, Q. Chen, Z.C. Wei, S. Cao, Y.H. Sun and Y. Li

The present study investigated the genetic characterization of red-colored heartwood Chinese fir [Cunninghamia lanceolata (Lamb.) Hook.] in Guangxi using 21 simple sequence repeat (SSR) markers and analyzes of the genetic variation (N = 149) in samples obtained from five sites in Guangxi Province, China. The number of different alleles and the Shannon’s information index per locus ranged .. Read More»

Genet. Mol. Res. 14(4): 2015.December.28.2

DOI: 10.4238/2015.December.28.2

P2X7 receptor in the hippocampus is involved in gp120-induced cognitive dysfunction

Y. Liu, G.Q. Chen, B.Y. Liu, Q. Chen, Y.M. Qian, S.S. Qin, C.L. Liu and C.S. Xu

To investigate the role of the P2X7 receptor in learning and memory dysfunction induced by HIV-1 envelope glycoprotein gp120 (gp120), we established HIV-1-associated dementia (HAD) animal models by intracerebroventricular (ICV) infusion of gp120 in rats. We observed gp120-induced cognitive dysfunction in the radial arm water maze test. Results showed that rats in th.. Read More»

Genet. Mol. Res. 16(1): gmr16019356

DOI: 10.4238/gmr16019356

Gene expression characteristics of growth-inhibited rice seedlings induced by low-energy N+-beam implantation

H. Ya, Q. Chen, W. Wang and Y. Cheng

Using the RNA sequencing, transcriptomes of growth-inhibited rice seedlings induced by low-energy N+-beam implantation were analyzed. The results showed that rice genes related to binding, electron carrier activity, transcription factor, auxin signal transduction, photosynthesis, and oxidoreductase activity were involved in the response to ion-beam implantation. Mor.. Read More»

Genet. Mol. Res. 13(3): 2014.August.15.9

DOI: 10.4238/2014.August.15.9

Screening and prevention of neonatal glucose 6-phosphate dehydrogenase deficiency in Guangzhou, China

J. Jiang, B. Li, W. Cao, X. Jiang, X. Jia, Q. Chen and J. Wu

We aimed to summarize the results of screening protocol and prevention of neonatal glucose 6-phosphate dehydrogenase (G6PD) deficiency during a 22-year-long period to provide a basis of reference for the screening of this disease. About 1,705,569 newborn subjects in Guangzhou City were screened for this deficiency. Specimens were collected according to the conventio.. Read More»

Genet. Mol. Res. 13(2): http://dx.doi.org/2014.June.9.13

DOI: http://dx.doi.org/10.4238/2014.June.9.13

Genome-wide analysis of TCP family in tobacco

L. Chen, Y.Q. Chen, A.M. Ding, H. Chen, F. Xia, W.F. Wang and Y.H. Sun

The TCP family is a transcription factor family, members of which are extensively involved in plant growth and development as well as in signal transduction in the response against many physiological and biochemical stimuli. In the present study, 61 TCP genes were identified in tobacco (Nicotiana tabacum) genome. Bioinformatic methods were employed for predicting an.. Read More»

Genet. Mol. Res. 15(2): gmr.15027728

DOI: 10.4238/gmr.15027728

Effects of mycophenolate mofetil on the expression of monocyte chemoattractant protein-1 and fibronectin in high glucose cultured human mesangial cells

F.Q. Chen, Q.Y. Wang, G.Z. Wei, X.Y. Ma, D.W. Ma, W.W. Deng and W.B. Sun

The effects of high glucose on the expression of monocyte chemoattractant protein-1 (MCP-1) and the main component of the extracellular matrix, fibronectin (FN), were explored in human mesangial cells (HMCs), along with the intervention effects of mycophenolate mofetil (MMF) on these indicators. Cultured HMCs were divided into five groups: 1) normal control group (5.. Read More»

Genet. Mol. Res. 13(2): 2014.April.17.11

DOI: 10.4238/2014.April.17.11

Association between the interleukin-1�² gene -511C/T polymorphism and ischemic stroke: an updated meta-analysis

W. Yan, Z.Y. Chen, J.Q. Chen and H.M. Chen

Numerous studies have investigated the relationship between the interleukin-1β gene (IL1B) -511C/T polymorphism and ischemic stroke (IS) risk. However, the results are inconsistent. We performed this meta-analysis of all available case-control studies that evaluated the relationship between the IL1B -511C/T polymorphism and IS. Studies were retrieved from the P.. Read More»

Genet. Mol. Res. 15(2): gmr.15027580

DOI: 10.4238/gmr.15027580

Clinical application of carbon nanoparticle lymph node tracer in the VI region lymph node dissection of differentiated thyroid cancer

S.P. Sun, Y. Zhang, Z.Q. Cui, Q. Chen, W. Zhang, C.X. Zhou, P.P. Xie and B.G. Liu

The application and clinical significance of carbon nanoparticle lymph tracer in the VI region (central region) lymph node dissection of differentiated thyroid cancer was investigated. Eighty patients with differentiated thyroid cancer were equally divided into the carbon nanoparticle-marked group (ipsilateral thyroid injection) and the control group (no injection)... Read More»

Genet. Mol. Res. 13(2): http://dx.doi.org/2014.April.30.4

DOI: http://dx.doi.org/10.4238/2014.April.30.4

Molecular characterization of a cytosolic manganese superoxide dismutase from the Chinese mitten crab, Eriocheir sinensis

D.X. Zhao1,2, L.Q. Chen1, J.G. Qin3, C.J. Qin1, H. Zhang1, P. Wu1 and E.C. Li

A cytosolic manganese superoxide dismutase gene (Es-cMnSOD) was cloned from the Chinese mitten crab Eriocheir sinensis, using reverse transcription-polymerase chain reaction and the rapid amplification of cDNA ends. The open reading frame of Es-cMnSOD is 867 bp in length and encodes a 288-amino acid protein without a signal peptide. The calculated molecular mass of the translated protein of Es-.. Read More»

Genet. Mol. Res. 13(4):