Q. Xu
Differential gene expression in the peripheral blood of Chinese Sanhe cattle exposed to severe cold stress
Livestock is an important food resource for the inhabitants of cold regions, such as northern Asia and alpine regions, where agriculture is limited. In these regions, cold stress largely affects livestock production, thereby reducing the productivity and survival of animals. Despite the importance of breeding cold-tolerant animals, few studies have investigated the .. Read More»
Genet. Mol. Res. 16(2): gmr16029593
DOI: 10.4238/gmr16029593
Correlation of UGT1A1 and ERCC1 gene polymorphisms with the outcome of combined irinotecan plus cisplatin treatment in recurrent ovarian cancer
The aim of this study was to define the genotypes of UGT1A1 and ERCC1 and to examine their relationship with the efficacy and toxicity of a combination therapy of irinotecan and cisplatin in patients with advanced ovarian cancer. The allelic frequencies of the UGT1A1 and ERCC1 variants in a group of 89 patients with advanced ovarian cancer were determined. The relationship between the adverse e.. Read More»
Genet. Mol. Res. 14(2): 2015.June.29.17
DOI: 10.4238/2015.June.29.17
Genetic polymorphisms of CCND1 and PTEN in progression of esophageal squamous carcinoma
Cyclin D1 (CCND1) plays a significant role in G1-S transition of cell cycle, and phosphatase and a tensin homologue (PTEN) negatively regulate cell cycle through phosphatidylinositol 3-kinase (PI3K)/AKT signaling. CCND1 and PTEN genetic polymorphisms might induce susceptibility to the occurrence of esophageal squamous cell carcinoma (ESCC). Three hundred and four ESCC patients and 413 healthy c.. Read More»
Genet. Mol. Res. 12(4): 2013.December.13.2
DOI: 10.4238/2013.December.13.2
Differential expression and effect of the porcine ANGPTL4 gene on intramuscular fat
In a previous study, we investigated differences in gene expression in backfat between Meishan and Large White pigs and their F1 hybrids, Large White x Meishan, and Meishan x Large White pigs. One potential differentially expressed sequence tag from the mRNA differential display was a homolog of the human angiopoietin-like 4 (ANGPTL4) gene, which encodes a protein t.. Read More»
Genet. Mol. Res. 13(2): 2014.April.16.3
DOI: 10.4238/2014.April.16.3
Identification of differently expressed genes in leukemia using multiple microarray datasets
The purpose of this study was to identify differentially expressed genes and analyze biological processes related to leukemia. A meta-analysis was performed using the Rank Product package of Gene Expression Omnibus datasets for leukemia. Next, Gene Ontology-enrichment analysis and pathway analysis were performed using the Gene Ontology website and Kyoto Encyclopedia of Genes and Genomes. A prot.. Read More»
Genet. Mol. Res. 13(4): 2014.December.12.9
DOI: 10.4238/2014.December.12.9
Pivotal role of microRNA-9 in osteosarcoma tumorigenesis and tumor progression
MicroRNA-9 (miR-9) has a well-established role in various tumors; the clinical significance and potential mechanism of miR-9 in human osteosarcoma (OS) has not been elucidated. The aim of this study was to investigate the mechanism and role of miR-9 expression in osteosarcoma cells. miR-9 expression in the OS cell line MG-63 and OS tissues was compared to that in a human osteoblastic cell line .. Read More»
Genet. Mol. Res. 15(1): gmr.15017318
DOI: 10.4238/gmr.15017318
Polymorphisms in interleukin-6 and interleukin-10 may be associated with risk of preeclampsia
Preeclampsia is a common condition unique to pregnant women. Previous studies have suggested that several cytokines may contribute to defective placental invasion and endothelial damage in this condition. We investigated the influence of four single nucleotide polymorphisms (SNPs) in the promoters of IL-6 (-572G/C, -597G/A, and -174G/C) and IL-10 (-592A/C) on suscep.. Read More»
Genet. Mol. Res. 16(1): gmr16018588
DOI: 10.4238/gmr16018588
Expression of RUNX3 gene in pancreatic adenocarcinoma and its clinical significance
We investigated the clinical significance of RUNX3 gene expression in human pancreatic carcinoma. Five samples of pancreatic tissues and 30 samples of pancreatic cancer tissues and paracancerous tissues were collected. RUNX3 expression was detected by real-time PCR and immunohistochemistry. The relationships between clinicopathological findings and the expression of.. Read More»
Genet. Mol. Res. 13(2): http://dx.doi.org/2014.May.23.4
DOI: http://dx.doi.org/10.4238/2014.May.23.4
Metastatic renal cell carcinoma to the left maxillary sinus
Metastatic tumors in the paranasal sinuses are very rare. The origin of metastatic tumors in the paranasal sinuses is often renal cancer. Renal cell carcinomas are known for their tendency for early metastasis, and symptoms due to the metastatic lesion may be the only initial manifestation. In this paper, we deal with the case of a 35-year-old male patient who prese.. Read More»
Genet. Mol. Res. 13(3): 2014.September.12.12
DOI: 10.4238/2014.September.12.12
Inheritance of cytosine methylation patterns in purebred versus hybrid chicken lines
We used methylation-sensitive amplified polymorphism to examine DNA methylation levels and CCGG patterns in parents and offsprings of 3 groups of adult chickens, purebred White Leghorn (AA), White Plymouth Rock (EE), and crossbred individuals (EA) using 10 primer combinations. We found that about 66% of the cytosines at CCGG sites were not methylated. Fully methylated sites were less frequent t.. Read More»
Genet. Mol. Res. 12(3): 2013.July.30.6
DOI: 10.4238/2013.July.30.6
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