R.C.P.C. Silva

Publications of : R.C.P.C. Silva

Human Genetics Research Article

Infertility caused by an association between Arg72Pro polymorphism of the p53 gene and Glu298Asp of the eNOS gene in patients with endometriosis

Endometriosis is characterized by ectopic endometrial tissue and affects millions of women worldwide. The disease leads to various symptoms such as chronic pelvic pain and infertility and does not yet have a well-defined etiology. The pathology is similar to cancer, since endometrial cells are highly proliferative, invade tissues and may be associated with tumor sup.. Read More»

Genet. Mol. Res. 17(3): http://dx.doi.org/gmr18046

DOI: http://dx.doi.org/10.4238/gmr18046

Medical Genetics Research Article

RsaI polymorphism of the ER�?² gene in women with endometriosis

R.C.P.C. Silva, I.R. Costa, B.M Bordin, C.T.X. Silva, S.R. Souza, C.L.R. JÃÆÃÂºnior, A.B. Frare and K.K.V.O. Moura

We examined the frequency of RsaI polymorphism of the ERβ gene in 54 patients diagnosed with endometriosis and 46 controls. Peripheral blood was collected from women undergoing laparoscopy with a confirmed diagnosis of endometriosis. Polymorphisms of the ERβ gene and p53 were assessed by PCR and analyzed on 2% agarose gel stained with ethidium bromide. The.. Read More»

Genet. Mol. Res. 10(1): vol10-1gmr940

DOI: 10.4238/vol10-1gmr940

Medical Genetics Research Article

GSTM1 and GSTT1 polymorphisms in endometriosis in women from Goi�?¡s, Brazil

A.B. Frare, A.M. Barbosa, I.R. Costa, S.R. Souza, R.C.P.C. Silva, B.M. Bordin, C.L. Ribeiro JÃÆÃÂºnior and K.K.V.O. Moura

Endometriosis is a gynecologic pathology with a high prevalence and unknown etiology. Therefore, an increasing number of studies has been undertaken to search for associations between endometriosis and alterations or polymorphisms in candidate genes, including glutathione S-transferase mu 1 (GSTM1) and glutathione S-transferase theta 1 (GSTT1). We analyzed the frequency of present/absent polymo.. Read More»

Genet. Mol. Res. 12(3): 2013.August.2.1

DOI: 10.4238/2013.August.2.1

Human Genetics Research Article

Polymorphism of the progesterone receptor gene associated with endometriosis in patients from Goi�?¡s, Brazil

I.R. Costa, R.C.P.C. Silva, A.B. Frare, C.T.X. Silva, B.M. Bordin, S.R. Souza, C.L. Ribeiro JÃÆÃÂºnior and K.K.V.O. Moura

We investigated a possible link between endometriosis and polymorphism of the progesterone receptor gene (PROGINS). The endometriosis group consisted of 54 patients with a diagnosis of endometriosis by laparoscopy, and the control group comprised 44 women without endometriosis. Genotypes for PROGINS polymorphisms (A1/A1, A1/A2 and A2/A2) were determined by polymeras.. Read More»

Genet. Mol. Res. 10(3): vol10-3gmr913

DOI: 10.4238/vol10-3gmr913