R.R. Moura

Synergic effect of oral contraceptives, GSTP1 polymorphisms, and high-risk HPV infection in development of cervical lesions

• B.S. Chagas
• A.P.A.D. Gurgel
• S.S.L. Paiva JÃ?ºnior
• R.C.P. Lima
• M.N. Cordeiro
• R.R. Moura
• A.V.C. Coelho
• K.C.G. Nascimento
• J.C. Silva Neto
• S. Crovella
• A.C. Freitas

Human papillomavirus (HPV) infection is considered a risk factor for cervical cancer. Even if the high-risk HPV (HR-HPV) infection is necessary, environmental co-factors and genetic susceptibility also play an important role in cervical cancer development. In this study, a possible association of rs1695 GSTP1 polymorphisms, HR-HPV infection, and oral contraceptive u.. Read More»

Genet. Mol. Res. 16(3): gmr16039742

DOI: 10.4238/gmr16039742

Distribution of forensic marker allelic frequencies in Pernambuco, Northestern Brazil

S.M. Santos, C.A. Souza2, K.C.N. Rabelo, P.R.E. Souza,R.R. Moura, T.C. Oliveira, and S. Crovella

Pernambuco is one of the 27 federal units of Brazil, ranking seventh in the number of inhabitants. We examined the allele frequencies of 13 short tandem repeat loci (CFS1PO, D3S1358, D5S818, D7S820, D8S1179, D13S317, D16S539, D18S51, D21S11, FGA, TH01, vWA, and TPOX), the minimum recommended by the Federal Bureau of Investigation and commonly used in forensic genetics laboratories in Brazil, in.. Read More»

Genet. Mol. Res. 14(2): http://dx.doi.org/2015.April.30.2

DOI: http://dx.doi.org/10.4238/2015.April.30.2

A rapid screening of ancestry for genetic association studies in an admixed population from Pernambuco, Brazil

A.V.C. Coelho, R.R. Moura, C.A.J. Cavalcanti, R.L. Guimarães,P. Sandrin-Garcia, S. Crovella and L.A.C. Brandão

Genetic association studies determine how genes influence traits. However, non-detected population substructure may bias the analysis, resulting in spurious results. One method to detect substructure is to genotype ancestry informative markers (AIMs) besides the candidate variants, quantifying how much ancestral populations contribute to the samples’ genetic background. The present study .. Read More»

Genet. Mol. Res. 14(1):

HLA-G genetic variants and hepatocellular carcinoma: a meta-analysis

A.V.C. Coelho, R.R. Moura, S. Crovella and F. Celsi

Human leukocyte antigen (HLA)-G is a key tolerogenic molecule mainly expressed in the placenta and is crucial for implantation of the embryo and immunological tolerance of the fetus during pregnancy. However, under pathological conditions, such as cancer or viral infections, HLA-G can be expressed in other tissues. The gene coding for HLA-G (HLA-G, chromosome 6p21.3) presents numerous polymorph.. Read More»

Genet. Mol. Res. 15(3): gmr.15038263

DOI: 10.4238/gmr.15038263

Detecting multiple DNA human profile from a mosquito blood meal

K.C.N. Rabêlo, C.M.R. Albuquerque, V.B. Tavares, S.M. Santos, C.A. Souza, T.C. Oliveira, R.R. Moura, L.A.C. Brandão and S. Crovella

Criminal traces commonly found at crime scenes may present mixtures from two or more individuals. The scene of the crime is important for the collection of various types of traces in order to find the perpetrator of the crime. Thus, we propose that hematophagous mosquitoes found at crime scenes can be used to perform genetic testing of human blood and aid in suspect investigation. The aim ofthe.. Read More»

Genet. Mol. Res. 15(3): gmr.15037547

DOI: 10.4238/gmr.15037547