S. Jiang

miR-367 promotes uveal melanoma cell proliferation and migration by regulating PTEN

• J.W. Ling
• P.R. Lu
• Y.B. Zhang
• S. Jiang
• Z.C. Zhang

We aimed to investigate the biological role of miR-367 in uveal melanoma cell growth and migration, and the underlying mechanism responsible. Quantitative real-time polymerase chain reaction was performed to evaluate miR-367 expression in uveal melanoma tissue samples and cell lines. A miR-367 mimic, miR-367 inhibitor, and negative control oligonucleotide were trans.. Read More»

Genet. Mol. Res. 16(3): gmr16039067

DOI: 10.4238/gmr16039067

Comparisons of different myosin heavy chain types, AMPK, and PGC-1�± gene expression in the longissimus dorsi muscles in Bama Xiang and Landrace pigs

Y.N. Huang, Q.W. Ao, Q.Y. Jiang, Y.F. Guo, G.Q. Lan and H.S. Jiang

Bama Xiang and Landrace pigs are the local fatty and lean breeds, respectively, in China. We compared differences in carcass traits, meat quality traits, and myosin heavy chain (MyHC) types in the longissimus dorsi muscles between Bama Xiang and Landrace pigs. This was done in pigs of the same age, using real-time PCR, to investigate the relationship between MyHC fiber types and carcass charact.. Read More»

Genet. Mol. Res. 15(2):

Study of the methylation patterns of the EGFR gene promoter in non-small cell lung cancer

Z.Y. Pan, Z.S. Jiang and H.Q. Ouyang

We investigated the methylation state of the epidermal growth factor receptor (EGFR) gene promoter in non-small cell lung cancer (NSCLC) and analyzed its effect on tumor biology. We enrolled 120 patients with NSCLC who had been confirmed by pathologic diagnosis and had been operated on. The methylation states of the EGFR gene promoter were detected and analyzed and a prognosis was given. NSCLC .. Read More»

Genet. Mol. Res. 14(3): 2015.August.19.14

DOI: 10.4238/2015.August.19.14

Mitochondrial ND3 G10398A mutation: a biomarker for breast cancer

Y. Yu, F. Lv, H. Lin, G. Qian, Y.S. Jiang, L.X. Pang, Y.P. Wang, X.F. Wang, Y.M. Kang, C.B. Li, Q. Liu, J.Z. Xu and W. You

Mitochondrial DNA mutations have been found to play important roles in carcinogenesis. The most common G10398A mutation, a non-conservative amino acid substitution from Thr to Ala, seems to be involved in the tumorigenesis of breast cancer. Results from studies concerning this mutation remain inconclusive. In the current study, we first took clinical and molecular datasets from case-control stu.. Read More»

Genet. Mol. Res. 14(4): 2015.December.21.12

DOI: 10.4238/2015.December.21.12

Gene expression and enzyme activity of lipoprotein lipase correlate with intramuscular fat content in Guangxi san-huang and Arbor Acres chickens

Y.N. Huang, J. Wang, B.J. Chen, Q.Y. Jiang, Y.F. Guo, G.Q. Lan and H.S. Jiang

Lipoprotein lipase (LPL) is a key enzyme in lipid metabolism. This study investigated LPL gene expression, LPL enzyme activity, and the correlation of each with intramuscular fat (IMF) in Chinese Guangxi san-huang (GXSH) and Arbor Acres (AA) chickens. The results showed that age and breed had significant effects on LPL expression and enzyme activity. Correlation ana.. Read More»

Genet. Mol. Res. 15(2): gmr.15027414

DOI: 10.4238/gmr.15027414

Myoglobin A79G polymorphism association with exercise-induced skeletal muscle damage

T. Cui and M.S. Jiang

We assessed the role of A79G, a polymorphism of the myoglobin gene (MB), in susceptibility to exercise-induced skeletal muscle damage. Between January 2012 and December 2014, a total of 166 cases with exercise-induced skeletal muscle damage and 166 controls were recruited into our study. Genotyping of MB A79G was carried out using polymerase chain reaction coupled w.. Read More»

Genet. Mol. Res. 15(2): gmr.15027506

DOI: 10.4238/gmr.15027506

In vivo and in vitro inhibitory action of 17�²-estradiol and environmental estrogen 4-nonylphenol on gonad-inhibiting hormone (GIH) expression in the eyestalks of Litopenaeus vannamei

G.L. Li*, H.P. Chen*, S.P. Deng, M. Ye, S. Jiang, S.F. Chan and C.H. Zhu

The gonad-inhibiting hormone (GIH) belongs to a neuropeptide family synthesized and released in an X-organ sinus gland complex of crustacean eyestalks. GIH inhibits crustacean ovarian maturation by suppressing vitellogenin (Vtg) synthesis, whereas estrogen is responsible for the stimulation of vitellogenesis (not established). In this study, the effects of 17β-estradiol (E2, 10-6 M), estro.. Read More»

Genet. Mol. Res. 14(4): 2015.October.29.25

DOI: 10.4238/2015.October.29.25

H558R polymorphism in SCN5A is associated with Keshan disease and QRS prolongation in Keshan disease patients

S. Jiang, F.L. Li, Q. Dong, H.W. Liu, C.F. Fang, C. Shu, H. Cheng, J. Cui, H.X. Ma, D.Q. Chen, H. Li

Keshan disease (KSD), a potentially fatal cardiomyopathy, has very high incidence in some selenium-poor regions of China. KSD may be accompanied with a variety of arrhythmia, which is associated with mutations in the gene coding for cardiac voltage-gated sodium channel (SCN5A). The molecular mechanism of KSD is still largely obscure. We aimed to determine t.. Read More»

Genet. Mol. Res. 13(3): 2014.August.28.1

DOI: 10.4238/2014.August.28.1

Complete mitochondrial genome of the Cyclemys dentata and phylogenetic analysis of the major family Geoemydidae

Y.N. Huang, J. Li, Q.Y. Jiang, X.S. Shen, X.Y. Yan, Y.B. Tang, J. Huang, Y.F. Guo, G.Q. Lan and H.S. Jiang

In the present study, the complete mitochondrial (mt) genome of Cyclemys dentata was determined using PCR reactions. The structural organization and gene order of C. dentata were equivalent to those of most other vertebrates. The mt genome was 16,489 bp in length, has rich A+T content, consisting of 13 protein-coding genes, 2 ribosomal RNA genes, 22 transfer RNA genes, and a control region (D-l.. Read More»

Genet. Mol. Res. 14(2): http://dx.doi.org/2015.April.13.2

DOI: http://dx.doi.org/10.4238/2015.April.13.2

Molecular characterization, expression, and functional analysis of chicken TRAF6

J. Jin, J.S. Ran, C.W. Yang, X.S. Jiang, Y.G. Zhou, Z.Q. Feng, Y. Wang, D. Lan, P. Ren and Y.P. Liu

Tumor necrosis factor receptor-associated factor 6 (TRAF6) is a crucial adaptor molecule of the interleukin-1 receptor/Toll-like receptor (IL-1/TLR) superfamily, which can trigger downstream signaling cascades involved in innate immunity. The function of TRAF6 has been clarified in mammals but is poorly understood in chicken. In our study, we investigated TRAF6 func.. Read More»

Genet. Mol. Res. 16(1): gmr16019138

DOI: 10.4238/gmr16019138