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S.Q. Chen

Publications of : S.Q. Chen
Human Genetics   Research Article

Characterization and development of 56 EST-SSR markers derived from the transcriptome of Odontobutis potamophila

Expressed sequence tags (ETSs) are the sources of microsatellite development. In this study, we isolated and characterized microsatellite markers for Odontobutis potamophila by using Illumina RNA-sequencing. We sequenced a large number of ESTs and screened 200 potential microsatellites. Consequently, a total of 56 novel polymorphic mic.. Read More»

Genet. Mol. Res. 16(2): gmr16029129

DOI: 10.4238/gmr16029129

Human Genetics   Research Article

Expression and clinical implications of enhancer of Zeste homolog 2 and p53 protein in squamous cell carcinoma and precancerous lesions in the cervix

    H.M. Zhang, S.Q. Chen and S.Z. Yao

We investigated the expression and clinical implications of enhancer of Zeste homolog 2 (EZH2) and p53 protein in cervical squamous cell carcinoma (SCC) and precancerous lesions. EZH2 and p53 expressions in SCC (168), cervical intraepithelial neoplasia (CIN)-I (19), CIN-II (35), and normal tissues (30) were detected by streptavidin-peroxidase-conjugation. The correl.. Read More»

Genet. Mol. Res. 15(2): gmr.15027408

DOI: 10.4238/gmr.15027408

Plant Genetics   Research Article

A SCAR marker for the analysis of chloroplast DNA from different cultivars of Cornus officinalis

    L. Zhang, R.X. Liu, J. Wang, T. Zhang, J. Li, J.H. Shi, B.Y. Kang and S.Q. Chen

The aims of this study were to establish a random amplified polymorphic DNA (RAPD) fingerprint database of chloroplast DNA (cpDNA) from different cultivars of Cornus officinalis and to convert RAPD markers to sequence characterized amplified regions (SCAR) markers. A method of extraction was established that was suitable for obtaining cpDNA from samples rapidly dried in silicone; an RAPD finger.. Read More»

Genet. Mol. Res. 14(4): 2015.December.16.17

DOI: 10.4238/2015.December.16.17

Human Genetics   Research Article

Effect of human umbilical cord mesenchymal stem cells on endometriotic cell proliferation and apoptosis

    L.N. Xu, N. Lin, B.N. Xu, J.B. Li and S.Q. Chen

The objective of this study was to observe the effects of human umbilical cord mesenchymal stem cells (UCMSCs) on the proliferation and apoptosis of endometriotic cells. Endometriotic cells and UCMSCs were primarily cultured in vitro. In the experimental group, a UCMSC and endometriotic cell non-contact co-culture system was established. The control group consisted of 1 x 105 endometriotic cell.. Read More»

Genet. Mol. Res. 14(4): 2015.December.11.2

DOI: 10.4238/2015.December.11.2

Human Genetics   Research Article

A common genetic variant of 5p15.33 is associated with risk for prostate cancer in the Chinese population

    Q. Ren, B. Xu, S.Q. Chen, Y. Yang, C.Y. Wang, Y.D. Wang, X.H. Wang, L.X. Hua and M. Chen

Recent evidence has suggested that single-nucleotide polymorphisms (SNPs) located at 5p15.33 contribute to susceptibilities for several cancer types, including prostate cancer. To determine whether SNP rs402710 in this region plays a role in prostate cancer, we analyzed these associations in a Chinese population; 251 prostate cancer patients and 273 control subjects.. Read More»

Genet. Mol. Res. 11(2): 2012.May.15.5

DOI: 10.4238/2012.May.15.5

Microbial Genetics   Research Article

Effect of miR-146a polymorphism on biochemical recurrence risk after radical prostatectomy in southern Chinese population

    M. Chen, Z.Y. Zhou, J.G. Chen, N. Tong, S.Q. Chen, Y. Yang, X.W. Zhang, H. Jiang, N. Liu, J. Liu, G.Z. Sha, W.D. Zhu, L.X. Hua, Z.J. Wang and B. Xu

Evidence has shown that miR-146a is involved in carcinogenesis and a common G/C variant (rs2910164) in the pre-miR-146a gene has been found to be associated with various cancers. We investigated the potential prognostic role of miR-146a polymorphism in prostate cancer after radical prostatectomy... Read More»

Genet. Mol. Res. 13(4): 2014.December.18.3

DOI: 10.4238/2014.December.18.3

Human Genetics   Research Article

DNMT3A -448A>G polymorphism and cancer risk: a meta-analysis

    C.H. Liu,T. Tao1,L. Jiang1,B. Xu,L. Zhang, K. Lu,X.W. Zhang,S.Q. Chen,D.C. Liu and M. Chen

Cancer is a major public health problem worldwide that involves complex processes and factors. For instance, methylation is important in tumorigenesis. DNA (cytosine-5)-methyltransferase 3A (DNMT3A) is the main de novo methyltransferase implicated in this process. In DNMT3A, the -448A>G polymorphism is associated with cancer; however, the results of various studies have been conflicting. To .. Read More»

Genet. Mol. Res. 14(2): http://dx.doi.org/2015.April.17.14

DOI: http://dx.doi.org/10.4238/2015.April.17.14