T.C. Vieira

Molecular Diagnosis of X-Fragile Syndrome: Perspectives for the Public Health System in the Central Region of Brazil

• K.B. Penteado
• C.I.S. Gressler
• A.D. Da Cruz
• T.C. Vieira
• M.A. D. Gigonzac

X-Fragile Syndrome (FXS) is the most common cause of inherited intellectual disability and the second of genetic origin, with an estimated prevalence of 1/4000 men and 1/6000 women. The etiology is associated with a trinucleotide expansion of CGG sequences and hypermethylation of the promoter region of the FMR1 (Fragile-X Mental Retardation-1) gene, located in the X.. Read More»

Genet. Mol. Res. 16(4): gmr16039848

DOI: 10.4238/gmr16039848

Lack of association between IL-10 -1082G/A polymorphism and chronic periodontal disease in adults

R. Hannum, F.R. Godoy , A.S. da Cruz, T.C. Vieira, L.B. Minasi, D. de M. e Silva, C.C. da Silva and A.D. da Cruz

Because of the complex interaction between periodontal pathogens and the host defense system, periodontitis is considered an inflammatory disorder of bacterial etiology that results in periodontal tissue damage. Genetic mechanisms may interfere with the gene expression of important inflammation mediators, modulating the immunologic response of an individual. In this study, we evaluated the sing.. Read More»

Genet. Mol. Res. 14(4): 2015.December.22.7

DOI: 10.4238/2015.December.22.7

Association between an ACAN gene variable number tandem repeat polymorphism and lumbar disc herniation: a case control study

N.L.L. Casa, A.J. Casa Junior, A.V. Melo, L.S. Teodoro,G.R. Nascimento, A.F. Sousa, T.C. Flausino, D. Brito, R. Bergamini, L.B. Minasi, A.D. da Cruz, T.C. Vieira and M.P. Curado

We investigated the association between an aggrecan gene (ACAN) polymorphism and lumbar disc herniation (LDH). This was a case-control study with quinquennial age and gender groups. The study comprised 119 men and women aged between 20 and 60 from Goiânia (Brazil). Of these, 39 were allocated to the case group (Ca) and 80 to the control group (Ct). We gathered.. Read More»

Genet. Mol. Res. 15(4): gmr15048867

DOI: 10.4238/gmr15048867

Allele frequencies of combined DNA index system (CODIS) and non-CODIS short tandem repeat loci in Goi�?¡s, Central Brazil

R.G. Rodovalho, G.S. Santos, L.M. Cavalcanti, B.F.S.M. Moura, E.L. Rodrigues, P.R. Lima, M.A.D. Gigonzac and T.C. Vieira

In studies of human identification, obtaining a high standard of outcomes and satisfactory conclusions are directly related to the use of highly polymorphic molecular markers. In addition to the combined DNA index system (CODIS) group, it is also important to implement non-CODIS markers into the analysis, as they increase the power of discrimination. During the identification process, it is ess.. Read More»

Genet. Mol. Res. 14(3): 2015.July.3.6

DOI: 10.4238/2015.July.3.6

Cytogenetic damage in the buccal epithelium of Brazilian aviators occupationally exposed to agrochemicals

L.B. Minasi, E.O.A. Costa, D.M. Silva, C.O.A. Melo, J.G. de Almeida, T.C. Vieira, R.L. Silva Júnior, C.L.Ribeiro, C.C. da Silva and A.D. da Cruz

The frequency of micronuclei in both buccal cells and peripheral blood lymphocytes is extensively used as a biomarker of chromosomal damage and genome stability in human populations. We examined whether prolonged exposure to complex mixtures of Short Communication pesticides leads to an increase in cytogenetic damage. The exposed group comprised 50 agricultural avia.. Read More»

Genet. Mol. Res. 10(4):

Allelic frequencies and statistical data obtained from 15 STR loci in a population of the Goi�?¡s State

T.C. Vieira D.M. Silva M.A.D. Gigonzac V.L. Ferreira M.W. Gonçalves A.D da Cruz

Due to the miscegenation of the Brazilian population, the central region of Brazil was colonized by internal migration of individuals from different origins, who contributed to the genetic diversity existing in this population. The purpose of this study was to estimate population parameters based on the allele frequencies for 15 polymorphic autosomal short-tandem repeat (STR) loci present in the p.. Read More»

Genet. Mol. Res. 12(1): 2013.January.16.5

DOI: 10.4238/2013.January.16.5

Y-STR haplotype diversity and population data for Central Brazil: implications for environmental forensics and paternity testing

T.C. Vieira, M.A.D. Gigonzac, D.M. Silva, R.G. Rodovalho, G.S. Santos and A.D. da Cruz

The central region of Brazil was colonized by internal migration of individuals of different origins, who contributed to the genetic diversity existing in this population. This study determined the allele frequencies and haplotype diversity of Y-STRs in Goiás State, Central Brazil, and compared the data obtained with a sample of the Brazilian population, cons.. Read More»

Genet. Mol. Res. 13(2): http://dx.doi.org/2014.April.30.1

DOI: http://dx.doi.org/10.4238/2014.April.30.1