W. Wang
Isolation and characterization of polymorphic microsatellite markers for the chub mackerel (Scomber japonicus) and cross-species amplification in the blue mackerel (S. australasicus)
In this study, 10 polymorphic microsatellite markers were developed in Scomber japonicus and were examined on 30 individuals collected from the North Pacific. The number of alleles per locus ranged from 4 to 17. The observed and expected heterozygosities per locus ranged from 0.2759 to 0.8621 and from 0.43071 to 0.9177, respectively. The polymorphism information con.. Read More»
Genet. Mol. Res. 16(3): gmr16039712
DOI: 10.4238/gmr16039712
Meta-analysis of TAFI polymorphisms and risk of cardiovascular and cerebrovascular diseases
Cardiovascular and cerebrovascular diseases (CCVDs) are common and have high rates of morbidity, mortality, and recurrence. Thrombin-activatable fibrinolysis inhibitor (TAFI) is also known as carboxypeptidase B2 and is encoded by the CPB2 gene; CPB2 polymorphisms have been explored in a variety of studies, but their correlation to the risk of CCVDs remains ambiguous.. Read More»
Genet. Mol. Res. 15(2): gmr.15026718
DOI: 10.4238/gmr.15026718
Expression profile of insulin-like growth factor system genes in muscle tissues during the postnatal development growth stage in ducks
Insulin-like growth factors (IGFs) are regulators that modulate the proliferation and differentiation of muscle tissues. We quantified the messenger RNA (mRNA) expression of IGF-I, IGF-II, and type I and II IGF receptors (IGF-IR and IGF-IIR) in muscle tissues including the breast, leg, and myocardium during an early postnatal development growth stage (post-hatching weeks 1-8) in ducks. The resu.. Read More»
Genet. Mol. Res. 12(4): 2013.May.6.3
DOI: 10.4238/2013.May.6.3
Genome-wide analysis of immunophilin FKBP genes and expression patterns in Zea mays
The receptors for the immunosuppression drugs FK506 and rapamycin are called FKBPs (FK506-binding proteins). FKBPs comprise a large family; they are found in many species, including bacteria, fungi, animals, and plants. As a class of peptidyl-prolyl cis-trans isomerase enzymes, the FKBP genes have been the focus of recent studies on plant stress tolerance and immuno.. Read More»
Genet. Mol. Res. 11(2): 2012.June.25.2
DOI: 10.4238/2012.June.25.2
Relationship between genetic polymorphisms of methylenetetrahydrofolate reductase and breast cancer chemotherapy response
Activity of methylenetetrahydrofolate reductase (MTHFR), an enzyme involved in folate metabolism, is influenced by mutations in the corresponding gene, contributing to a decrease in 5,10-MTHF. Due to such polymorphisms, individuals differ in MTHFR enzyme activity and plasma folate levels. We investigated the relationship between two common MTHFR polymorphisms (C677T and A1298C) and breast cance.. Read More»
Genet. Mol. Res. 15(3): gmr.15038679
DOI: 10.4238/gmr.15038679
Role of salubrinal in protecting cardiomyocytes from doxorubicin-induced apoptosis
We determined whether salubrinal can protect cardiomyocytes from doxorubicin-induced apoptosis and explored the related mechanisms to provide experimental evidence for exploring novel drug candidates to decrease cardiac toxicity. Neonatal rat cardiomyocytes were isolated, cultured in vitro, and pretreated with salubrinal (10, 20, or 40 μM) to observe their r.. Read More»
Genet. Mol. Res. 14(4): 2015.October.16.4
DOI: 10.4238/2015.October.16.4
Molecular cloning and expression of drought-induced protein 3 (DIP3) encoding a class III chitinase in upland rice
A drought-induced gene, DIP3, encoding a chitinase III protein was isolated from the roots of upland rice by reverse transcription-polymerase chain reaction (RT-PCR). Sequence analysis demonstrated that the cDNA and deduced protein showed high identity to Oryza sativa class III chitinase. The deduced protein contained a signal peptide sequence in the N-terminal region of 21aa and a conserved gl.. Read More»
Genet. Mol. Res. 12(4): 2013.December.19.5
DOI: 10.4238/2013.December.19.5
MicroRNA expression profile of a Malaysian Bajau family with familial mitochondrial neurogastrointestinal encephalomyopathy
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a rare, autosomal recessive disorder associated with mutations in the thymidine phosphorylase (TYMP) gene. The main objective of this study was to characterize the genetic profiles of the deceased proband’s family members (N = 4) using DNA sequencing and to determine miRNA deregulation in MNGIE using miRNA microarray profili.. Read More»
Genet. Mol. Res. 14(4): 2015.October.26.13
DOI: 10.4238/2015.October.26.13
Propofol induces apoptosis and inhibits the proliferation of rat embryonic neural stem cells via gamma-aminobutyric acid type A receptor
We investigated the effect of propofol on the proliferation and viability of rat embryonic neural stem cells (rENSCs) and the potential mechanisms involved. rENSCs were isolated and cultured in vitro and treated with 1, 10, or 50 μM propofol, while the control group was treated with 0.1 μM dimethyl sulfoxide. The effect of propofol on the proliferatio.. Read More»
Genet. Mol. Res. 14(4): 2015.November.18.57
DOI: 10.4238/2015.November.18.57
A Medicago truncatula H+-pyrophosphatase gene, MtVP1, improves sucrose accumulation and anthocyanin biosynthesis in potato (Solanum tuberosum L.)
We recently cloned MtVP1, a type I vacuolar-type H+-translocating inorganic pyrophosphatase from Medicago truncatula. In the present study, we investigated the cellular location and the function of this H+-PPase in Arabidopsis and potato (Solanum tuberosum L.). An MtVP1::enhanced green fluorescent protein fusion was constructed, which localized to the plasma membran.. Read More»
Genet. Mol. Res. 13(2): http://dx.doi.org/2014.May.9.4
DOI: http://dx.doi.org/10.4238/2014.May.9.4
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