W.Z. Li

Association of interleukin-6 gene polymorphisms and circulating levels with keloid scars in a Chinese Han population

• X.J. Zhu
• W.Z. Li
• H. Li
• C.Q. Fu
• J. Liu

The aim of the present study is to explore the effect of IL-6 gene polymorphisms on the development of keloid scar (KS) in the Chinese Han population. Genotyping of IL-6 was performed by the polymerase chain reaction (PCR), followed by restriction fragment length polymorphism assays (PCR-RFLP). Serum level of IL-6 was measured using enzyme-linked immunosorbent assay.. Read More»

Genet. Mol. Res. 16(2):

Association of the interleukin-10 gene -1082A/G genetic polymorphism with risk of ischemic stroke in a Chinese population

W.Z. Li, C.Y. Gao, W.L. He and H.M. Zhang

We investigated the possible association between two single nucleotide polymorphisms of IL10 (-1082A/G and -592C/A) and susceptibility to ischemic stroke. In total, 335 patients with proven ischemic stroke and 335 control subjects were recruited from Xinxiang Central Hospital between March 2013 and May 2015. The IL10 -1082A/G and -529C/A polymorphisms were investigated by polymerase chain react.. Read More»

Genet. Mol. Res. 15(1): gmr.15017541

DOI: 10.4238/gmr.15017541

Association between a microRNA-214 binding site polymorphism in the methylenetetrahydrofolate reductase gene and esophageal squamous cell carcinoma

G.R. Shen, W.Z. Li, Y.C. Liu, X.P. Li and H.Y. Yuan

MicroRNAs (miRNAs) are key regulators of gene expression and play an important role in the development and progression of various diseases including esophageal squamous cell carcinoma (ESCC). In this study, we determined whether a polymorphism at the miR-214 binding site in the 3'-untranslated region (3'-UTR) of the methylenetetrahydrofolate reductase gene (MTHFR) i.. Read More»

Genet. Mol. Res. 15(2): gmr.15028158

DOI: 10.4238/gmr.15028158

Protective effect of the n-butanol Toona sinensis seed extract on diabetic nephropathy rat kidneys

W.Z. Li, X.H. Wang, H.X. Zhang, S.M. Mao and C.Z. Zhao

The objective of this study was to observe the protective effect of the n-butyl alcohol phase of Toona sinensis seed extract on the kidneys of diabetic nephropathy (DN) rats and its preliminary mechanism. Male wistar rats were administered a normal or high-fat diet for 1 month. DN rats were divided into a model group and a petroleum ether phase of T. sinensis seed e.. Read More»

Genet. Mol. Res. 15(1): gmr.15017403

DOI: 10.4238/gmr.15017403

Hypoxia facilitates epithelial-mesenchymal transition-mediated rectal cancer progress

L.L. Sun, Z. Song, W.Z. Li and S.Y. Tang

Rectal cancer is a commonly observed tumor in clinics, and epithelial-mesenchymal transition (EMT) is very important for tumor invasion and metastasis. We established a rectal cancer HCT-116 cell hypoxia model and detected cell proliferation, invasion, and EMT-related protein expression in this model, aiming to analyze the effect of hypoxia on rectal cancer cell EMT.. Read More»

Genet. Mol. Res. 15(4): gmr15048936

DOI: 10.4238/gmr15048936

Cloning, sequence characterization, and expression patterns of members of the porcine TSSK family

P. Wang, H.L. Huo, S.Y. Wang, Y.W. Miao, Y.Y. Zhang, Q.L. Zhang, F.Q. Li, L.X. Liu, W.Z. Li, Y.Z. Zeng, J.L. Huo and H. Xiao

Testis-specific serine kinases (TSSKs) are a family of serine/threonine kinases highly expressed in the testes that are responsible for regulating many spermatogenesis-related protein activities. Mutations in this family have a positive relationship with oligospermia and azoospermia in human and mouse. Here, five members of the TSSK family from a Banna mini-pig inbr.. Read More»

Genet. Mol. Res. 14(4): 2015.October.18.56

DOI: 10.4238/2015.October.18.56