X.L. Su
Clinical significance and expression of PUMA, MCL-1, and p53 in human renal cell carcinoma and para-carcinoma tissues
We investigated the expression level of p53 upregulated modulator of apoptosis (PUMA), myeloid cell leukemia-I (MCL-1), and p53 in renal cell carcinoma (RCC) and para-carcinoma tissues, as well as their clinical significance. The expression levels of PUMA, MCL-1, and p53 in RCC and para-carcinoma tissues were measured using immunohistochemical and quantitative real-.. Read More»
Genet. Mol. Res. 16(3): gmr16039278
DOI: 10.4238/gmr16039278
CCDC26 rs4295627 polymorphism (8q24.21) and glioma risk: a meta-analysis
The association between the CCDC26 rs4295627 single nucleotide polymorphism (SNP) and the glioma risk has been studied previously, but these studies have yielded conflicting results. The aim of the present study is to analyze this association more vigorously, by means of a meta-analysis. A comprehensive literature search was performed in databases PubMed and EMBASE... Read More»
Genet. Mol. Res. 14(4): 2015.October.5.20
DOI: 10.4238/2015.October.5.20
Association of variants in renal salt reabsorption-related gene SLC12A3 with essential hypertension in a Mongolian population
Mounting evidence has implicated the SLC12A3 gene in essential hypertension. Here, we examined the potential associations of common variants of the SLC12A3 gene with blood pressure traits in Mongolians in China. Genomic DNA was extracted from 508 unrelated Mongolian patients with essential hypertension and 246 normotensive Mongolian subjects for genotyping. The genotype distributions of all sel.. Read More»
Genet. Mol. Res. 14(3): 2015.August.21.9
DOI: 10.4238/2015.August.21.9
Association between serum angiopoietin-2 concentration and clinicopathological parameters in patients with colorectal cancer
We examined the expression of angiopoietin-2 in serum samples from patients diagnosed with colorectal cancer and healthy volunteers and investigated the feasibility of using angiopoietin-2 as a potential diagnostic colorectal cancer biomarker. Enzyme-linked immunosorbent assays were used to measure the levels of angiopoietin-2 in patients with colorectal cancer and .. Read More»
Genet. Mol. Res. 14(4): 2015.December.1.5
DOI: 10.4238/2015.December.1.5
Correlation between PPARg2 gene Pro12Ala polymorphism and cerebral infarction in an Inner Mongolian Han Chinese population
The variant of PPAR-g2 has been shown to promote the increase of carotid IMT in patients suffering from cerebral infarction and the Pro12Ala polymorphism in the peroxisome proliferator-activated receptorg2 (PPARg2) gene may be associated with cerebral infarction. However, due to the different genetic background, race, and regional variations of cerebral infarction p.. Read More»
Genet. Mol. Res. 15(2): gmr.15027332
DOI: 10.4238/gmr.15027332
High methylation of the SEPT9 gene in Chinese colorectal cancer patients
Methylation of the septin 9 gene (SEPT9) occurs in higher frequency in colorectal cancer (CRC) compared to control samples, which suggests that SEPT9 methylation is a useful biomarker for screening CRC. However, the methylation status of SEPT9 in Chinese CRC patients is scarcely reported. In the present study, SEPT9 methylation was tested in CRC tissues obtained fro.. Read More»
Genet. Mol. Res. 13(2): 2014.January.17.5
DOI: 10.4238/2014.January.17.5
Association between peroxisome proliferator-activated receptor gamma coactivator-1 alpha polymorphism and hypertension in Mongolians in Inner Mongolia
We investigated a possible association of peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) Gly482Ser polymorphism with hypertension in Mongolians in Inner Mongolia. A total of 787 subjects were enrolled randomly, including 390 hypertension patients and 397 healthy controls. Triglycerides, cholesterol, and fasting plasma glucose wer.. Read More»
Genet. Mol. Res. 10(4): 2011.December.12.2
DOI: 10.4238/2011.December.12.2
Genetic polymorphisms of cytochrome P450 enzymes 2C9 and 2C19 in a healthy Mongolian population in China
We examined the distribution of major allelic variants of CYP2C9 and CYP2C19 in the Mongolian population of China and compared it with that of other populations. The polymorphisms of CYP2C9 (including the CYP2C9*1, CYP2C9*2 and CYP2C9*3 alleles) and CYP2C19 (including the CYP2C19*1, CYP2C19*2 and CYP2C19*3 alleles) were analyzed in 280 healthy unrelated Chinese Mong.. Read More»
Genet. Mol. Res. 9(3): vol9-3gmr938
DOI: 10.4238/vol9-3gmr938
Association of a CYP4A11 polymorphism and hypertension in the Mongolian and Han populations of China
Human cytochrome P450 4A11 (CYP4A11) plays a role in the regulation of blood pressure through the conversion of arachidonic acid into 20-hydroxyeicosatetraenoic acid (20-HETE). We therefore investigated the association between a CYP4A11 polymorphism (rs9333025) with hypertension in the Mongolian and Han ethnic groups. We studied 514 Mongolians in a pastoral area, in.. Read More»
Genet. Mol. Res. 13(1): 2014.January.21.20
DOI: 10.4238/2014.January.21.20
Detection of Jaagsiekte sheep retrovirus in the peripheral blood during the pre-clinical period of ovine pulmonary adenomatosis
The envelope protein (Env) of the Jaagsiekte sheep retrovirus (JSRV) is known to be a unique oncoprotein responsible for inducing ovine pulmonary adenocarcinoma (OPA). The objective of this study was to prepare a specific monoclonal antibody (mAb) against the JSRV Env protein using bioinformatic analysis. According to the structure and epitope prediction results of .. Read More»
Genet. Mol. Res. 15(3): gmr.15038521
DOI: 10.4238/gmr.15038521
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