X.Y. Xu
Identification of genes related to floral organ development in pak choi by expression profiling
Pak choi is a highly nutritious vegetable that is widely grown in China, Southeast Asia, and other parts of the world. Because it reproduces by seed, it is very important to understand the mechanism of floral organ development. Therefore, using the Chinese cabbage genome as a reference, this study analyzed the expression profiles of shoot apex genes at flower bud di.. Read More»
Genet. Mol. Res. 16(1): gmr16019233
DOI: 10.4238/gmr16019233
Linker length affects expression and bioactivity of the onconase fusion protein in Pichia pastoris
The aim of this study was to analyze the effect of linker length on the expression and biological activity of recombinant protein onconase (ONC) in fusion with human serum albumin (HSA) in Pichia pastoris. Four flexible linkers with different lengths namely Linker L0, L1: (GGGGS)1, L2: (GGGGS)2, and L3:(GGGGS)3 were inserted into the fusion gene and referred to as HSA-n-ONC, where N = 0, 5, 10,.. Read More»
Genet. Mol. Res. 14(4): 2015.December.29.46
DOI: 10.4238/2015.December.29.46
Decreased expression of tumor suppressive miR-874 and its clinical significance in human osteosarcoma
Dysregulation of microRNAs (miRs) is associated with cancer development and progression and aberrant expression of miR-874 have been found in some types of cancer. However, the expression and function of miR-874 in osteosarcoma remain unclear. The aim of this study was to explore the effects of miR-874 in osteosarcoma tumorigenesis and development. The expression level of miR-874 was quantified.. Read More»
Genet. Mol. Res. 14(4): 2015.December.23.19
DOI: 10.4238/2015.December.23.19
Polymorphisms of the angiotensin II type 1 receptor gene affect antihypertensive response to angiotensin receptor blockers in hypertensive Chinese
The renin-angiotensin-aldosterone system plays a key role in regulating blood pressure by maintaining vascular tone and the water/sodium balance. Many antihypertensive drugs target the renin-angiotensin-aldosterone system, but the effect differs considerably among hypertensive patients. We investigated whether genetic variants of the angiotensin II type 1 receptor are associated with blood pres.. Read More»
Genet. Mol. Res. 12(2): 2013.June.21.2
DOI: 10.4238/2013.June.21.2
Clinical significance of microRNA-34a in esophageal squamous cell carcinoma
MicroRNA-34a (miR-34a) has been found to be downregulated in esophageal squamous cell carcinoma (ESCC) tissues compared with that in normal tissues (P < 0.05), and miR-34a overexpression increased apoptosis and decreased clonogenic formation. However, the clinical significance and prognostic value of miR-34a in ESCC has not yet been investigated. In total, 111 patients with ESCC diagnosed an.. Read More»
Genet. Mol. Res. 14(4): 2015.December.21.41
DOI: 10.4238/2015.December.21.41
Characterization of FeDREB1 promoter involved in cold- and drought-inducible expression from common buckwheat (Fagopyrum esculentum)
C-repeat-binding factor (CBF)/dehydration-responsive element (DREB) transcription factors play key roles in plant stress responses. However, little information is available on the regulation of CBF/DREB expression. In this study, we isolated and characterized the FeDREB1 promoter sequence from the common buckwheat accession Xinong 9976. To identify the upstream region of the FeDREB1 gene requir.. Read More»
Genet. Mol. Res. 14(3): 2015.July.17.7
DOI: 10.4238/2015.July.17.7
Differential expression of interleukin-12 p35 and p40 subunits in response to Aeromonas hydrophila and Aquareovirus infection in grass carp, Ctenopharyngodon idella
The grass carp (Ctenopharyngodon idella) aquaculture industry in Asia is prone to bacterial and viral hemorrhagic diseases. Effective adjuvants for vaccine formulation are the need of the hour for control of these diseases and long-term sustainability of grass carp farming. In this study, the involvement of interleukin-12 (IL-12) from grass carp (gcILâÂ?Â?12) in anti-bacterial and anti-viral immu.. Read More»
Genet. Mol. Res. 14(1): 2015.February.6.20
DOI: 10.4238/2015.February.6.20
Association of interleukin-1�² -511C/T promoter polymorphism with COPD risk: a meta-analysis
Studies examining the role of interleukin (IL)-1β -511C/ T promoter polymorphism in the pathogenesis of chronic obstructive pulmonary disease (COPD) have shown inconsistent results. This metaanalysis was performed to assess the association between the IL-1β -511C/T promoter polymorphism and COPD susceptibility. Published case-control, cross-sectional, and cohort studies from Pubmed, E.. Read More»
Genet. Mol. Res. 14(2): 2015.May.4.5
DOI: 10.4238/2015.May.4.5
Unruptured saccular aneurysm presenting migraine
Headache can be attributed to cranial or cervical vascular disorders including ischemic stroke or transient ischemic attack, non-traumatic intracranial hemorrhage, unruptured vascular malformation, arteritis, carotid-vertebral artery pain, and cerebral venous thrombosis. Here, we present a case report of unruptured saccular aneurysm with migraine. The patient was a .. Read More»
Genet. Mol. Res. 13(2): 2014.January.24.19
DOI: 10.4238/2014.January.24.19
A 425 T>C polymorphism in complement C7 association with resistance to Aeromonas hydrophila in grass carp
Aeromonas hydrophila, a widespread bacterium in the aquatic environment, causes hemorrhagic septicemia in fish. In the last decade, the disease has caused mass mortalities and tremendous economic loss in cultured fish. The complement component C7 is a terminal component of complement that interacts in a sequence of polymerization reactions with other terminal comple.. Read More»
Genet. Mol. Res. 15(1): gmr.15014526
DOI: 10.4238/gmr.15014526
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