Y. Cai
Suppression of the biological activity of neuroglioma cells by down-regulation of miR-1
Neuroglioma is associated with high rates of malignancy, metastasis, and recurrence. Recently, research on the roles of microRNAs (miR) in cancer prognosis has formed an important area of research as differential expression of miRNAs has been observed in different cancers. However, the detailed mechanism by which miRNAs regulate glioma remains unknown. Thus, we inve.. Read More»
Genet. Mol. Res. 16(3): gmr16039256
DOI: 10.4238/gmr16039256
MYH9 gene polymorphisms may be associated with cerebrovascular blood flow in patients with type 2 diabetes
Genetic factors play an important role in type 2 diabetes (T2D) complications. Alteration of cerebrovascular blood flow (CBF) is a direct result of cerebrovascular diseases. However, few studies have reported the role of genetics on CBF in patients with T2D. We investigated whether single-nucleotide polymorphisms (SNPs) in metabolic disease genes are associated with CBF in patients with T2D. CB.. Read More»
Genet. Mol. Res. 14(1): 2015.February.6.4
DOI: 10.4238/2015.February.6.4
Quantitative candidate gene association studies of metabolic traits in Han Chinese type 2 diabetes patients
Recent genome-wide association studies have identified many loci associated with type 2 diabetes mellitus (T2DM), hyperuricemia, and obesity in various ethnic populations. However, quantitative traits have been less well investigated in Han Chinese T2DM populations. We investigated the association between candidate gene single nucleotide polymorphisms (SNPs) and met.. Read More»
Genet. Mol. Res. 14(4): 2015.November.30.25
DOI: 10.4238/2015.November.30.25
Long interspersed nucleotide acid element-1 ORF-1 protein promotes proliferation and invasion of human colorectal cancer LoVo cells through enhancing ETS-1 activity
The human proto-oncogene long interspersed nucleotide acid element-1 (LINE-1) open reading frame-1 protein (ORF-1p) is involved in the progress of several cancers. The transcription factor ETS-1 can mediate the transcription of some downstream genes that play specific roles in the regulation of cancerous cell invasion and metastasis. In this study, the effects of LI.. Read More»
Genet. Mol. Res. 13(3): 2014.April.14.13
DOI: 10.4238/2014.April.14.13
Genetic diversity and relationship analysis of Gossypium arboreum accessions
Simple sequence repeat techniques were used to identify the genetic diversity of 101 Gossypium arboreum accessions collected from India, Vietnam, and the southwest of China (Guizhou, Guangxi, and Yunnan provinces). Twenty-six pairs of SSR primers produced a total of 103 polymorphic loci with an average of 3.96 polymorphic loci per primer. The average of the effective number of alleles, Nei&rsqu.. Read More»
Genet. Mol. Res. 14(4): 2015.November.18.15
DOI: 10.4238/2015.November.18.15
Clinical significance of CD44 expression in children with hepatoblastoma
The aim of this study was to investigate the expression of CD44 and its clinical significance in children suffering from hepatoblastoma (HB). CD44 expression was detected with immunohistochemistry staining in 30 samples from hepatoblastoma children and 10 normal liver tissue samples from normal children. The data obtained was statistically analyzed using the chi-square test, using the SPSS (v.1.. Read More»
Genet. Mol. Res. 14(4): 2015.October.26.16
DOI: 10.4238/2015.October.26.16
A novel splicing site mutation of the GPR143 gene in a Chinese X-linked ocular albinism pedigree
Ocular albinism is an X-linked inherited disease characterized by hypopigmentation of the iris and nystagmus. To identify a new disease-causing mutation of ocular albinism, we collected a Han Chinese pedigree with 7 male congenital nystagmus patients over 3 generations. Slit-lamp photography and optical coherence tomography were performed for the proband. Genomic DNA was extracted from a whole .. Read More»
Genet. Mol. Res. 12(4): 2013.November.18.16
DOI: 10.4238/2013.November.18.16
Real-time PCR evaluation of cell-free DNA subjected to various storage and shipping conditions
In this study, we attempted to explore the factors affecting the yield of cell-free fetal DNA (cffDNA) obtained from maternal blood samples, including the use of different types of collection tubes, the interval between sample processing, and sample shipping under extreme weather conditions. Blood samples were drawn into K3EDTA tubes and cell-stabilizing tubes (Stre.. Read More»
Genet. Mol. Res. 14(4): 2015.October.19.23
DOI: 10.4238/2015.October.19.23
Characterization and development of chloroplast microsatellite markers for Gossypium hirsutum, and cross-species amplification in other Gossypium species
Cotton is an important economic crop worldwide; its fiber, commonly known as cotton lint, is the main natural source for the textile industry. Sixty chloroplast microsatellites were identified and characterized from the complete sequence of the Gossypium hirsutum chloroplast genome using a bioinformatic approach. Twenty chloroplast microsatellite loci were polymorph.. Read More»
Genet. Mol. Res. 14(4): 2015.October.5.6
DOI: 10.4238/2015.October.5.6
Enhanced expression and significance of glycosylphosphatidylinositol anchor attachment protein 1 in colorectal cancer
The aim of this study was to investigate the expression of glycosylphosphatidylinositol anchor attachment protein 1 (GPAA1) and its significance in patients with colorectal cancer. Fifty-two patients with primary colorectal cancer were included in this study. GPAA1 expression was detected by immunohistochemistry, reverse transcription-polymerase chain reaction, and .. Read More»
Genet. Mol. Res. 13(1): 2014.January.21.19
DOI: 10.4238/2014.January.21.19
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