Y. Guo
A set of novel microsatellite markers developed for an economically important tree, Dracontomelon duperreanum, in China
Dracontomelon duperreanum, the most representative species of the family Anacardiaceae, is an important multipurpose tree in China and Vietnam. However, no genetic diversity studies have been reported on this species. In this study, we identified 11 microsatellite markers for D. duperreanum by using the restriction-site-associated DNA sequencing (RAD-seq) method and.. Read More»
Genet. Mol. Res. 16(2): gmr16029578
DOI: 10.4238/gmr16029578
Roles of ER�± and ER�² in estrogen-induced DDP chemoresistance in non-small cell lung cancer
The role of estrogen in inducing chemoresistance is not yet fully understood. The objective of this study was to observe the relationship between estrogen levels and cellular response to chemotherapeutic drugs in non-small cell lung cancer (NSCLC) and to reveal the potential mechanisms involved. Cell viability was analyzed after pre-treating NSCLC cells with different levels of estrogen (E2), f.. Read More»
Genet. Mol. Res. 15(3): gmr.15038995
DOI: 10.4238/gmr.15038995
A family-based association study identified CYP17 as a candidate gene for obesity susceptibility in Caucasians
The cytochrome P450c17α gene (CYP17) encodes a key biosynthesis enzyme of estrogen, which is critical in regulating adipogenesis and adipocyte development in humans. We therefore hypothesized that CYP17 is a candidate gene for predicting obesity. In order to test this hypothesis, we performed a family-based association test to investigate the relationship betw.. Read More»
Genet. Mol. Res. 11(3): 2012.May.22.1
DOI: 10.4238/2012.May.22.1
Development of new polymorphic microsatellite markers in topmouth culter (Culter alburnus) and determination of their applicability in Culter mongolicus
Fifteen new polymorphic microsatellite markers were developed for Culter alburnus. In 32 individuals representing a wild population of the Danjiangkou Reservoir, Hubei, China, the number of alleles at these loci varied between 2 and 10, with an average of 5.5. The average observed and expected heterozygosities were 0.664 and 0.681, respectively. The polymorphism information content of 11 loci w.. Read More»
Genet. Mol. Res. 12(2): 2013.May.21.7
DOI: 10.4238/2013.May.21.7
Development of microsatellite markers for Mytilus coruscus (Mytilidae), an economically important mussel in the East China Sea
Twelve new polymorphic microsatellite loci were developed for the hard-shelled mussel, Mytilus coruscus. In 32 individuals from a wild population of coastal Zhoushan, Zhejiang Province, China, the number of alleles at these loci varied from 3 to 15, with a mean of 5.667. The mean observed and expected heterozygosities were 0.6927 and 0.6591, respectively. Among these polymorphic microsatellite .. Read More»
Genet. Mol. Res. 12(3): 2013.July.30.5
DOI: 10.4238/2013.July.30.5
Sublingual vein parameters, AFP, AFP-L3,and GP73 in patients with hepatocellularcarcinoma
This study evaluated the diagnostic value of alphafetoprotein (AFP), AFP heterogeneity 3 (AFP-L3), Golgi protein 73 (GP73), and sublingual vein parameters in hepatocellular carcinoma (HCC). Levels of serum AFP, AFP-L3, GP73, and sublingual vein scores were measured in 34 patients with chronic hepatitis, 65 patients with post-hepatitis B cirrhosis, 71 patients with HCC, and 6 healthy controls. L.. Read More»
Genet. Mol. Res. 14(2): 2015.June.26.16
DOI: 10.4238/2015.June.26.16
cDNA cloning and mRNA expression of a tandem-repeat galectin (PoGal2) from the pearl oyster, Pinctada fucata
Galectins can recognize and specifically bind to β-galactoside residues, playing crucial roles in innate immune responses of vertebrates and invertebrates. We cloned the cDNA of a tandem-repeat galectin from the pearl oyster Pinctada fucata (designated as PoGal2). PoGal2 cDNA is 1347 bp long and consists of a 5êÂ?Â?-untranslated region (UTR) of 3 bp, a 3êÂ?Â?.. Read More»
Genet. Mol. Res. 10(3): vol10-3gmr1149
DOI: 10.4238/vol10-3gmr1149
Association between the expression of HIF-1�± and VEGF and prognostic implications in primary liver cancer
The goal of this study was to investigate the expression of hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) in primary liver cancer (PLC) and their association with prognosis. Tumor tissue, non-tumor tissue, and blood samples of 75 PLC patients were collected. Blood samples of 20 volunteers were also collected as health.. Read More»
Genet. Mol. Res. 15(2): gmr.15028107
DOI: 10.4238/gmr.15028107
MKL1-184C>T gene polymorphism is associated with coronary artery diseasein the Chinese Han population
We investigated genetic susceptibility to coronary artery disease (CAD) by studying the association of MKL1 gene polymorphisms with CAD in the Chinese Han population. We performed a case-control study with 476 unrelated CAD patients and 325 non-CAD controls. All SNPs were genotyped with a TaqMan SNP genotyping assay. The distribution of MKL1-184C>T gene polymorph.. Read More»
Genet. Mol. Res. 13(1): 2014.January.28.4
DOI: 10.4238/2014.January.28.4
Effects of eplerenone on the activation of matrix metalloproteinase-2 stimulated by high glucose and interleukin-1�² in human cardiac fibroblasts
The aim of this study was to determine the influence of high glucose (HG) and interleukin (IL)-1β on human cardiac fibroblast (HCF) functions, and to evaluate the effects of eplerenone in these responses. HCFs were cultured in normal or HG media in the absence or presence of IL-1β and/or eplerenone. We assessed matrix metalloproteinase-2 (MMP-2) activity i.. Read More»
Genet. Mol. Res. 13(3): 2014.January.24.4
DOI: 10.4238/2014.January.24.4
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