Hypoxia-inducible factor-1α (HIF-1α) is considered the main transcriptional regulator of the hypoxia-specific cellular and developmental response. This study was performed to investigate the effect of Shenqin biochemical extract (SQBE) on HIF-1α expression in ultraviolet B (UVB)-irradiated HaCaT cells and the possible action mechanisms of SQBE agai.. Read More»
Genet. Mol. Res. 16(2): gmr16029430
DOI: 10.4238/gmr16029430
We propose a novel representation of RNA secondary structure for a quick comparison of different structures. Secondary structure was viewed as a set of stems and each stem was represented by two values according to its position. Using this representation, we improved the comparative sequence analysis method results and the minimum free-energy model. In the comparati.. Read More»
Genet. Mol. Res. 10(3): vol10-3gmr1181
DOI: 10.4238/vol10-3gmr1181
Experimental and newly formed hybrids and polyploids generated by wide crosses usually show varying degrees of cytological instability. The spatial separation of parental genomes and uniparental chromosome elimination in hybrid cells has been reported in many hybrids from plants and animals. Herein, the behavior of parental genomes in intergeneric somatic hybrids be.. Read More»
Genet. Mol. Res. 13(2): 2014.April.8.3
DOI: 10.4238/2014.April.8.3
Many studies have shown that the pathogenesis of liver injury includes oxidative stress. MicroRNA-122 may be a marker for the early diagnosis of drug-induced liver injury. However, the relationship between microRNA-122 and oxidative stress in anti-tuberculosis drug-induced liver injury remains unknown. We measured changes in tissue microRNA-122 levels and indices of oxidative stress during live.. Read More»
Genet. Mol. Res. 14(4): 2015.October.26.22
DOI: 10.4238/2015.October.26.22
The purpose of this study was to identify the clinical features and mutations in the fibrillin-1 gene (FBN1) in a large Chinese family with autosomal dominant Marfan syndrome (MFS). Seventeen members from a Chinese family of 4 generations were included in the study. All members underwent complete ophthalmic examination. Molecular genetic analysis was performed on all subjects. All exons of FBN1.. Read More»
Genet. Mol. Res. 14(2): http://dx.doi.org/2015.April.27.27
DOI: http://dx.doi.org/10.4238/2015.April.27.27
We report here the course and treatment of a patient with ectopic pheochromocytoma. The patient was cured after treatment with respiratory and circulatory support, multiple-organ protection, and continuous renal replacement therapy (CRRT) for approximately 2 weeks. After misdiagnosis, a patient with ectopic pheochromocytoma who is being treated should undergo aggressive fluid supplementation an.. Read More»
Genet. Mol. Res. 14(1): 2015.March.20.25
DOI: 10.4238/2015.March.20.25
Synechococcus sp PCC 7336 represents a newly sequenced strain, and its genome is obviously different from that of other Synechococcus strains. In this analysis, local alignment and annotation databases were constructed and combined with various bioinformatic tools to carry out gene annotation and functional analysis of this strain. From this analysis, we identified .. Read More»
Genet. Mol. Res. 14(4): 2015.October.16.8
DOI: 10.4238/2015.October.16.8
Human hypertension is a complex, multifactorial disease. Multiple variants associated with hypertension have been identified in the large numbers of genome-wide association studies, meta-analysis, and case-control studies. The present study investigated the association between the single nucleotide polymorphisms (SNPs) of five candidate genes and the susceptibility and prognosis of hypertension.. Read More»
Genet. Mol. Res. 12(4): 2013.December.4.9
DOI: 10.4238/2013.December.4.9
Axonopus compressus (Sw.) Beauv. is a perennial herb widely used as a garden lawn grass. In this study, we used Roche 454 pyrosequencing, combined with the magnetic bead enrichment method FIASCO, to isolate simple sequence repeat markers from the A. compressus genome. A total of 1942 microsatellite loci were identified, with 53,193 raw sequencing reads. One hundred microsatellite loci were sele.. Read More»
Genet. Mol. Res. 14(2): 2015.May.11.2
DOI: 10.4238/2015.May.11.2
Myostatin is a secreted negative regulator of muscle mass, and follistatin antagonizes the function of several members of the TGF-b family, including myostatin. Previously, myostatin expression was found to be closely associated with atrophy of the gastrocnemius muscle, showing a linear correlation, after sciatic nerve injury. In this study, we investigated the poss.. Read More»
Genet. Mol. Res. 10(4): 2011.October.21.7
DOI: 10.4238/2011.October.21.7
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