Y. Shen
CADM1 mRNA expression and clinicopathological significance in esophageal squamous cell carcinoma tissue
The mRNA expression of cell adhesion molecule 1 (CADM1) and its clinicopathological significance in esophageal squamous cell carcinoma (ESCC) tissues were investigated. CADM1 mRNA and protein expression were detected in tissue samples from 50 patients with ESCC by reverse transcription-polymerase chain reaction (RT-PCR) and streptavidin-peroxidase (SP) immunohistoch.. Read More»
Genet. Mol. Res. 16(2): gmr16029178
DOI: 10.4238/gmr16029178
Higher frequency of CD4+CD25high Treg cells in hemophilia patients with factor VIII inhibitor
The production of factor VIII inhibitor antibodies remains the most costly and serious complication in replacement therapy of hemophilia A. We investigated the clinical significance of CD4+CD25high T regulatory (Treg) cells in hemophilia patients. Our trial included 6 severe hemophilia A patients with factor VIII inhibitors, 6 hemophilia patients without inhibition .. Read More»
Genet. Mol. Res. 13(1): http://dx.doi.org/2014.March.17.5
DOI: http://dx.doi.org/10.4238/2014.March.17.5
Inhibitory effect of microRNA-27b on interleukin 17 (IL-17)-induced monocyte chemoattractant protein-1 (MCP1) expression
We investigated the effect of microRNA-27b (miR-27b), a gene expression regulatory factor, on the expression of monocyte chemoattractant protein-1 (MCP1) stimulated by interleukin 17 (IL-17). After IL-17 had been added to H9C2 cardiomyocytes, an miR-27b mimic was transfected into the H9C2 cells. The mRNA expression levels of miR-27b and MCP1 in the H9C2 cells were d.. Read More»
Genet. Mol. Res. 15(2): gmr.15027784
DOI: 10.4238/gmr.15027784
Association of the estrogen receptor-�² gene RsaI and AluI polymorphisms with human idiopathic thin endometrium
The aim of this study was to investigate the potential correlation between polymorphisms of the estrogen receptor (ER)-β gene (RsaI and AluI) and ethnic Han Chinese human idiopathic thin endometrium. A total of 120 patients with idiopathic thin endometrium and 120 sterility patients with normal endometrium thickness (controls) were included in the study. RsaI a.. Read More»
Genet. Mol. Res. 12(4): 2013.November.26.7
DOI: 10.4238/2013.November.26.7
Alpaca fiber growth is mediated by microRNA let-7b via down-regulation of target gene FGF5
MicroRNAs are very small endogenous RNA molecules that play a crucial role in an array of biological processes, including regulation of skin morphogenesis. The microRNA let-7b is thought to modulate animal hair growth, by binding target genes that encode growth factors. Fibroblast growth factor 5 (FGF5) has been previously reported to be involved in the initiation of the catagen phase of hair g.. Read More»
Genet. Mol. Res. 14(4): 2015.October.28.38
DOI: 10.4238/2015.October.28.38
CTLA-4 and CD86 genetic variants and haplotypes in patients with rheumatoid arthritis in southeastern China
The cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and costimulatory molecule (CD80/CD86) genes are important susceptibility genes associated with autoimmune diseases. CTLA-4 polymorphisms have been found to be associated with various autoimmune diseases. However, the association data are inconsistent for rheumatoid arthritis (RA). We investigated the genetic association of CTLA-4 and CD8.. Read More»
Genet. Mol. Res. 12(2): 2013.April.25.8
DOI: 10.4238/2013.April.25.8
Effects of muscle fiber type on glycolytic potential and meat quality traits in different Tibetan pig muscles and their association with glycolysis-related gene expression
The myosin heavy chain (MyHC) composition, glycolytic potential, mitochondrial content, and gene expression related to energy metabolism were analyzed in eight muscles from Tibetan pigs, to study how meat quality develops in different muscle tissues. The muscles were classified into three clusters, based on MyHC composition: masseter, trapezius, and latissimus dorsi as ‘slow-oxidative-typ.. Read More»
Genet. Mol. Res. 14(4): 2015.November.13.22
DOI: 10.4238/2015.November.13.22
Cloning and expression of an APETALA1-like gene from Nelumbo nucifera
The objective of this study was to clone the full-length cDNA of the APETALA1 (AP1) gene from lotus and analyze its sequence and expression pattern. The full-length cDNA sequence of the NnAP1 gene was amplified from the petals of Nelumbo nucifera ‘Hongxia’ using RT-PCR and rapid amplification of cDNA ends. Bioinformatic methods were used to analyze the sequence characteristics of th.. Read More»
Genet. Mol. Res. 14(2): 2015.June.18.24
DOI: 10.4238/2015.June.18.24
Expression and clinical significance of ADAM17 protein in esophageal squamous cell carcinoma
We examined disintegrin and metalloproteinase 17 (ADAM17) protein expression in esophageal squamous cell carcinoma and its clinical and pathological correlated factors. Western blotting and immunohistochemistry were used to detect ADAM17 protein expression in esophageal squamous cell carcinoma and the corresponding normal esophageal mucosa in 50 cases. ADAM17 protein expression in 50 cases with.. Read More»
Genet. Mol. Res. 14(2): 2015.April.30.12
DOI: 10.4238/2015.April.30.12
Gynophore miRNA analysis at different developmental stages in Arachis duranensis
Peanut is one of the most important oilseed crops in the world that provides a significant amount of lipids and protein for many people. The gynophore plays an important role in gynophore development after fertilization of the peanut ovule. MicroRNAs (miRNAs) play an important role in numerous developmental and physiological plant processes. Therefore, it is essenti.. Read More»
Genet. Mol. Res. 15(4): gmr15048691
DOI: 10.4238/gmr15048691
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