Y.L. Wang
Cloning and functional characterization of the HbSYR1 gene encoding a syntaxin-related protein in Tibetan hulless barley (Hordeum vulgare L. var. nudum HK. f.)
Tibetan barley is a staple food for the natives of Qinghai-Tibet Plateau. Drought causes a reduction in barley production. In this study, the full-length cDNA of a gene encoding a syntaxin-associated protein was cloned from the leaves of a drought-resistant variety of barley, “Himalaya 10”; its expression was evaluated during drought stress and rehydrati.. Read More»
Genet. Mol. Res. 16(3): gmr16038909
DOI: 10.4238/gmr16038909
Genetic variability of ERCC1 and ERCC2 influences treatment outcomes in gastric cancer
We performed a study to investigate the role of ERCC1 (rs11615, rs2298881, and rs3212986) and ERCC2 (rs13181, rs238406, and rs1799793) polymorphisms in the prognosis of gastric cancer. A total of 346 patients with gastric cancer were recruited between May 2009 and May 2012. Single nucleotide polymorphism genotyping was performed using the Sequenom MassARRAY platform. The GA+AA genotype of ERCC2.. Read More»
Genet. Mol. Res. 14(4): 2015.December.21.25
DOI: 10.4238/2015.December.21.25
Selection and use of reference genes in mouse mammary glands
Obtaining quantitative data concerning gene expression is important for understanding milk synthesis in mammary glands. Quantitative real-time PCR (qRT-PCR) is an efficient tool to calculate gene expression; however, it is necessary to find valid reference genes for normalization of qRT-PCR data. We applied the geNorm software to eight commonly used reference genes .. Read More»
Genet. Mol. Res. 9(1): vol9-1gmr724
DOI: 10.4238/vol9-1gmr724
Leptin mRNA expression in the rat mammary gland at different activation stages
Leptin is expressed in various tissues, suggesting that this protein is effective not only at the central nervous system level, but also peripherically. Recent studies have shown leptin production by other tissues, including the placenta, stomach, and mammary tissues, but there is no information available concerning expression levels of leptin in the rat mammary gla.. Read More»
Genet. Mol. Res. 10(4): 2011.October.21.3
DOI: 10.4238/2011.October.21.3
Study of PIK3CA, BRAF, and KRAS mutations in breast carcinomas among Chinese women in Qinghai
Phosphatidylinositol-3-OH kinase and RAS-activated signaling pathways play an important role in tumor formation. Abnormalities in relevant genes play essential roles in the occurrence and development of many human cancers. Studies of breast cancer have mainly focused on the women in western countries, but few studies have examined the frequency of mutations in P.. Read More»
Genet. Mol. Res. 14(4): 2015.November.18.49
DOI: 10.4238/2015.November.18.49
Effects of VEGF/VEGFR/K-ras signaling pathways on miRNA21 levels in hepatocellular carcinoma tissues in rats
The aim of this study was to investigate the effects of the vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR)/K-ras signaling pathways on miRNA21 levels in hepatocellular carcinoma tissues in rats. Eighteen male Sprague-Dawley rats were randomly divided into normal control, model, and VEGF blocking agent groups (N = 6/group). The expression of VEGF mRNA, K-ras protein, and miRNA21 in.. Read More»
Genet. Mol. Res. 14(1): 2015.January.30.10
DOI: 10.4238/2015.January.30.10
Effects of curcumin on hippocampal expression of NgR and axonal regeneration in A�²-induced cognitive disorder rats
Curcumin has been widely used for the prevention and treatment of Alzheimer’s disease (AD), but its mechanism is still not clear. Inhibitory factors of axonal regeneration have been shown to cause a series of pathophysiological changes in the early period of AD. In this study, the co-receptor (Nogo receptor; NgR) of three axonal growth-inhibitory proteins was .. Read More»
Genet. Mol. Res. 13(1): 2014.March.24.8
DOI: 10.4238/2014.March.24.8
Correlation of serum high-sensitivity C-reactive protein and interleukin-6 in patients with acute coronary syndrome
Serum high-sensitivity C-reactive protein (hs-CRP) is a sensitive indicator of inflammation, which is closely related with the progress of plaque formation. Interleukin-6 (IL-6) is one of the inflammatory markers of local coronary plaque and the peripheral blood cycle, promoting the occurrence of atherosclerosis development and plaque rupture. In this study, the cor.. Read More»
Genet. Mol. Res. 13(2): http://dx.doi.org/2014.June.9.11
DOI: http://dx.doi.org/10.4238/2014.June.9.11
Survey and analysis of visual acuity of Kazakhs in different lighting environments
The effect of different lighting environments on the vision and refractive error were investigated in 427 Kazakhs (828 eyes) aged from 40 to 60 years old, of which 279 were pastoral (546 eyes) and 148 were urban (282 eyes). Pastoral Kazakhs use natural illumination, whereas city Kazakhs mainly use artificial illumination. Of all cases, 19.1% (54 cases) had a vision .. Read More»
Genet. Mol. Res. 13(2): 2014.April.3.17
DOI: 10.4238/2014.April.3.17
Association between -1082G/A, -819C/T, and -592C/A genetic polymorphisms in IL-10 and risk of type 2 diabetes mellitus in a Chinese population
Type 2 diabetes mellitus is the most common form of endocrine disease in humans; genetic factors are known to contribute to the development of this disease. In this case-control study, we investigated the relationship between the -1082G/A, -819C/T, and -592C/A polymorphisms in interleukin 10 (IL-10) and the pathogenesis of type 2 diabetes mellitus in a Chinese popul.. Read More»
Genet. Mol. Res. 15(3): gmr.15038559
DOI: 10.4238/gmr.15038559
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